Reactome | p-5Y-FGFR4 [plasma membrane]

p-5Y-FGFR4 [plasma membrane]

Stable Identifier

R-HSA-190330

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

phosphorylated FGFR4, Phosphorylated Fibroblast growth factor receptor 4, FGR4_HUMAN, FGFR4

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of signal transduction (Homo sapiens)
  - PI3K/AKT Signaling in Cancer (Homo sapiens)
    - Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
      - PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
        
        PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
        
        Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
        
        Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
        
        Activated FGFR4 [plasma membrane] (Homo sapiens)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
        
        p-5Y-FGFR4 [plasma membrane] (Homo sapiens)
        
        Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
        
        p-5Y-FGFR4 [plasma membrane] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
        
        Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
        
        Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
        
        Activated FGFR4 [plasma membrane] (Homo sapiens)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
        
        p-5Y-FGFR4 [plasma membrane] (Homo sapiens)
        
        Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
        
        p-5Y-FGFR4 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P22455 FGFR4

Gene Names

FGFR4, JTK2, TKF

Chain

signal peptide:1-21, chain:22-802

Reference Genes

BioGPS Gene:2264 FGFR4

COSMIC (genes):FGFR4 FGFR4

CTD Gene:2264 FGFR4

dbSNP Gene:2264 FGFR4

ENSEMBL:ENSG00000160867 FGFR4

ENSEMBL_homo_sapiens_GENE:ENSG00000160867 FGFR4

HGNC:3691 FGFR4

KEGG Gene (Homo sapiens):2264 FGFR4

Monarch:2264 FGFR4

NCBI Gene:2264 FGFR4

OMIM:134935 FGFR4

UCSC:P22455 FGFR4

Reference Transcript

Other Identifiers

0000110440

0001090372

0005290176

11735873_a_at

11740240_a_at

11744657_x_at

11752172_a_at

11753528_a_at

11757181_x_at

1291_s_at

1554962_a_at

16992957

1QCT

204579_at

211237_s_at

2264

27273

27369

28251

2842913

2842914

2842915

2842916

2842918

2842920

2842922

2842923

2842924

2842926

2842928

2842930

2842931

2842932

2842933

2842934

2842935

2842936

2842938

2842939

2842941

2842943

2842944

4QQ5

4QQC

4QQJ

4QQT

4QRC

4R6V

4TYE

4TYG

4TYI

4TYJ

4UXQ

4XCU

5196

5JKG

5NUD

5NWZ

8110265

A_14_P131381

A_23_P92754

AAA63208

AAB59389

AAF27432

AAH11847

AAK51435

AAM13666

ABQ01235

AEO19712

AEO19713

AEO19714

AEO19715

AEO19716

AEO19717

AEO19718

AEO19719

AEO19720

AEO19721

AEO19722

AEO19723

B5A964

CAA40490

CAA74200

CAB005196

CCDS4410

CCDS4411

D6R9V0

D6RG06

D6RJD4

E7EWF4

EAW85036

ENSG00000160867

ENSP00000292408

ENSP00000377254

ENSP00000424960

ENST00000292408

ENST00000393637

ENST00000502906

EntrezGene:2264

FGFR4

FGFR4-201

FGFR4-202

FGFR4-207

g13112051_3p_at

g6739817_3p_a_at

GE57553

GO:0000165

GO:0000166

GO:0001525

GO:0003674

GO:0004672

GO:0004713

GO:0004714

GO:0004888

GO:0005007

GO:0005088

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005622

GO:0005623

GO:0005737

GO:0005768

GO:0005783

GO:0005794

GO:0005886

GO:0005887

GO:0005911

GO:0006259

GO:0006464

GO:0006468

GO:0006629

GO:0007165

GO:0008150

GO:0008201

GO:0008219

GO:0008283

GO:0008284

GO:0008543

GO:0009058

GO:0009968

GO:0010628

GO:0010715

GO:0016020

GO:0016021

GO:0016301

GO:0016303

GO:0016310

GO:0016477

GO:0016740

GO:0017134

GO:0018108

GO:0019216

GO:0019899

GO:0030133

GO:0030154

GO:0030198

GO:0031410

GO:0032991

GO:0034641

GO:0036092

GO:0040011

GO:0042592

GO:0042593

GO:0042632

GO:0043066

GO:0043085

GO:0043167

GO:0043226

GO:0043235

GO:0043410

GO:0044281

GO:0045862

GO:0046777

GO:0046854

GO:0046934

GO:0048646

GO:0048856

GO:0048870

GO:0051897

GO:0055062

GO:0070374

GO:0070857

GO:2000573

HGNC:3691

HPA027273

HPA027369

HPA028251

ILMN_1730355

ILMN_2241412

ILMN_2410713

IPR000719

IPR001245

IPR003598

IPR003599

IPR007110

IPR008266

IPR011009

IPR013098

IPR013783

IPR016248

IPR017441

IPR020635

IPR036179

J3KPQ0

L03840_s_at

MIM:134935

NM_001354984

NM_002011

NM_022963

NM_213647

NP_001341913

NP_002002

NP_075252

NP_998812

PF07679

PF07714

PF13927

PH_hs_0010000

PR00109

SM00219

SM00408

SM00409

TC05001010.hg

uc003mfl.4

uc003mfm.4

uc003mfo.4

UPI000012A72D

UPI000013E0B8

XM_005265838

XM_011534464

XM_011534465

XP_005265895

Participant Of

hasComponent

Other forms of this molecule

FGFR4 Y367C [plasma membrane]

FGFR4 N535K [plasma membrane]

FGFR4 V550E [plasma membrane]

FGFR4 V550L [plasma membrane]

FGFR4 N535D [plasma membrane]

p-5Y-FGFR4 V550E [plasma membrane]

p-5Y-FGFR4 N535K [plasma membrane]

p-5Y-FGFR4 V550L [plasma membrane]

p-5Y-FGFR4 N535D [plasma membrane]

p5Y-FGFR4 Y367C mutant [plasma membrane]

FGFR4 [plasma membrane]

Inferred To

Homologues of p-5Y-FGFR4 [plasma membrane] (Canis familiaris)

Homologues of p-5Y-FGFR4 [plasma membrane] (Danio rerio)

Homologues of p-5Y-FGFR4 [plasma membrane] (Drosophila melanogaster)

Homologues of p-5Y-FGFR4 [plasma membrane] (Sus scrofa)

phospho-p-5Y-FGFR4 [plasma membrane] (Bos taurus)

phospho-p-5Y-FGFR4 [plasma membrane] (Canis familiaris)

phospho-p-5Y-FGFR4 [plasma membrane] (Danio rerio)

phospho-p-5Y-FGFR4 [plasma membrane] (Drosophila melanogaster)

phospho-p-5Y-FGFR4 [plasma membrane] (Gallus gallus)

phospho-p-5Y-FGFR4 [plasma membrane] (Mus musculus)

phospho-p-5Y-FGFR4 [plasma membrane] (Rattus norvegicus)

phospho-p-5Y-FGFR4 [plasma membrane] (Sus scrofa)

phospho-p-5Y-FGFR4 [plasma membrane] (Taeniopygia guttata)

phospho-p-5Y-FGFR4 [plasma membrane] (Xenopus tropicalis)

Modified Residues

Name

O4'-phospho-L-tyrosine at 643

Coordinate

643

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 642

Coordinate

642

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 719

Coordinate

719

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 754

Coordinate

754

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 764

Coordinate

764

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_998812.1, NP_075252.2, NP_001278909.1, XP_005265895.1, NP_002002.3

ZINC - World Drugs

FGFR4_HUMAN

OpenTargets

ENSG00000160867

ZINC - FDA approved

FGFR4_HUMAN

ZINC - Substances

FGFR4_HUMAN

ZINC target

P22455

PRO

P22455

PDB

5XFF, 4QRC, 4TYJ, 4TYE, 4QQT, 4QQC, 5XFJ, 5NWZ, 4R6V, 4UXQ, 4TYG, 5JKG, 4QQ5, 4QQJ, 5NUD, 4XCU, 1QCT, 4TYI

GeneCards

P22455

DOCK Blaster

4TYG, 4QQJ, 4TYJ, 4QRC, 5JKG, 4QQC, 4TYI, 4TYE, 4XCU, 4QQ5, 4UXQ, 4R6V, 4QQT

BRENDA (Homo sapiens)

2.7.10.1

Orphanet

24538

ZINC - Predictions - Purchasable

FGFR4_HUMAN

HMDB Protein

HMDBP01234