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p5Y-FGFR4 Y367C mutant [plasma membrane]
Stable Identifier
R-HSA-2011873
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by FGFR in disease (Homo sapiens)
Signaling by FGFR4 in disease (Homo sapiens)
Activated FGFR4 mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activated FGFR4 mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4 mutants:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4 mutants:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 mutants [plasma membrane] (Homo sapiens)
Activated FGFR4 Y367C mutant [plasma membrane] (Homo sapiens)
p5Y-FGFR4 Y367C mutant [plasma membrane] (Homo sapiens)
Activated FGFR4 mutants bind FRS2 (Homo sapiens)
Activated FGFR4 mutants [plasma membrane] (Homo sapiens)
Activated FGFR4 Y367C mutant [plasma membrane] (Homo sapiens)
p5Y-FGFR4 Y367C mutant [plasma membrane] (Homo sapiens)
Activated FGFR4 mutants:FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 mutants [plasma membrane] (Homo sapiens)
Activated FGFR4 Y367C mutant [plasma membrane] (Homo sapiens)
p5Y-FGFR4 Y367C mutant [plasma membrane] (Homo sapiens)
Activated FGFR4 mutants bind PLCG1 (Homo sapiens)
Activated FGFR4 mutants [plasma membrane] (Homo sapiens)
Activated FGFR4 Y367C mutant [plasma membrane] (Homo sapiens)
p5Y-FGFR4 Y367C mutant [plasma membrane] (Homo sapiens)
Activated FGFR4 mutants:PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR4 mutants [plasma membrane] (Homo sapiens)
Activated FGFR4 Y367C mutant [plasma membrane] (Homo sapiens)
p5Y-FGFR4 Y367C mutant [plasma membrane] (Homo sapiens)
Activated FGFR4 mutants phosphorylate FRS2 (Homo sapiens)
Activated FGFR4 mutants:FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 mutants [plasma membrane] (Homo sapiens)
Activated FGFR4 Y367C mutant [plasma membrane] (Homo sapiens)
p5Y-FGFR4 Y367C mutant [plasma membrane] (Homo sapiens)
Activated FGFR4 mutants:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 mutants [plasma membrane] (Homo sapiens)
Activated FGFR4 Y367C mutant [plasma membrane] (Homo sapiens)
p5Y-FGFR4 Y367C mutant [plasma membrane] (Homo sapiens)
Activated FGFR4 mutants phosphorylate PLCG1 (Homo sapiens)
Activated FGFR4 mutants:PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR4 mutants [plasma membrane] (Homo sapiens)
Activated FGFR4 Y367C mutant [plasma membrane] (Homo sapiens)
p5Y-FGFR4 Y367C mutant [plasma membrane] (Homo sapiens)
Activated FGFR4 mutants:p-4Y-PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR4 mutants [plasma membrane] (Homo sapiens)
Activated FGFR4 Y367C mutant [plasma membrane] (Homo sapiens)
p5Y-FGFR4 Y367C mutant [plasma membrane] (Homo sapiens)
Activated FGFR4 mutants:p-FRS2 binds GRB2-SOS1 (Homo sapiens)
Activated FGFR4 mutants:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 mutants [plasma membrane] (Homo sapiens)
Activated FGFR4 Y367C mutant [plasma membrane] (Homo sapiens)
p5Y-FGFR4 Y367C mutant [plasma membrane] (Homo sapiens)
FGFR4 mutants:p-FRS2:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR4 mutants:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 mutants [plasma membrane] (Homo sapiens)
Activated FGFR4 Y367C mutant [plasma membrane] (Homo sapiens)
p5Y-FGFR4 Y367C mutant [plasma membrane] (Homo sapiens)
Activated FGFR4 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)
Activated FGFR4 mutants:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 mutants [plasma membrane] (Homo sapiens)
Activated FGFR4 Y367C mutant [plasma membrane] (Homo sapiens)
p5Y-FGFR4 Y367C mutant [plasma membrane] (Homo sapiens)
Activated FGFR4 mutants:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4 mutants:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 mutants [plasma membrane] (Homo sapiens)
Activated FGFR4 Y367C mutant [plasma membrane] (Homo sapiens)
p5Y-FGFR4 Y367C mutant [plasma membrane] (Homo sapiens)
Activated FGFR4 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)
Activated FGFR4 mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4 mutants:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4 mutants:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 mutants [plasma membrane] (Homo sapiens)
Activated FGFR4 Y367C mutant [plasma membrane] (Homo sapiens)
p5Y-FGFR4 Y367C mutant [plasma membrane] (Homo sapiens)
Activated FGFR4 mutants:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4 mutants:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 mutants [plasma membrane] (Homo sapiens)
Activated FGFR4 Y367C mutant [plasma membrane] (Homo sapiens)
p5Y-FGFR4 Y367C mutant [plasma membrane] (Homo sapiens)
Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
FGFR4 mutants:p-FRS2:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR4 mutants:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 mutants [plasma membrane] (Homo sapiens)
Activated FGFR4 Y367C mutant [plasma membrane] (Homo sapiens)
p5Y-FGFR4 Y367C mutant [plasma membrane] (Homo sapiens)
FGFR4 mutant receptor activation (Homo sapiens)
Autocatalytic phosphorylation of FGFR4 Y367C mutant (Homo sapiens)
Activated FGFR4 Y367C mutant [plasma membrane] (Homo sapiens)
p5Y-FGFR4 Y367C mutant [plasma membrane] (Homo sapiens)
p-4Y-PLCG1 dissociates from activated FGFR4 mutants (Homo sapiens)
Activated FGFR4 mutants [plasma membrane] (Homo sapiens)
Activated FGFR4 Y367C mutant [plasma membrane] (Homo sapiens)
p5Y-FGFR4 Y367C mutant [plasma membrane] (Homo sapiens)
Activated FGFR4 mutants:p-4Y-PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR4 mutants [plasma membrane] (Homo sapiens)
Activated FGFR4 Y367C mutant [plasma membrane] (Homo sapiens)
p5Y-FGFR4 Y367C mutant [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P22455 FGFR4
Gene Names
FGFR4, JTK2, TKF
Chain
signal peptide:1-21, chain:22-802
Reference Genes
BioGPS Gene:2264 FGFR4
COSMIC (genes):FGFR4 FGFR4
CTD Gene:2264 FGFR4
dbSNP Gene:2264 FGFR4
ENSEMBL:ENSG00000160867 FGFR4
HGNC:3691 FGFR4
KEGG Gene (Homo sapiens):2264 FGFR4
Monarch:2264 FGFR4
NCBI Gene:2264 FGFR4
OMIM:134935 FGFR4
UCSC:P22455 FGFR4
Reference Transcript
RefSeq:NM_213647.2 FGFR4
RefSeq:NM_002011.4 FGFR4
RefSeq:NM_022963.3 FGFR4
RefSeq:XM_005265838.3 FGFR4
RefSeq:NM_001291980.1 FGFR4
Other Identifiers
0000110440
0001090372
0005290176
11735873_a_at
11740240_a_at
11744657_x_at
11752172_a_at
11753528_a_at
11757181_x_at
1291_s_at
1554962_a_at
16992957
204579_at
211237_s_at
2264
2842912
2842913
2842914
2842915
2842916
2842918
2842920
2842922
2842923
2842924
2842926
2842928
2842930
2842931
2842932
2842933
2842934
2842935
2842936
2842938
2842939
2842941
2842943
2842944
8110265
A_14_P131381
A_23_P92754
GE57553
GO:0000165
GO:0000166
GO:0003674
GO:0004672
GO:0004713
GO:0004714
GO:0005007
GO:0005515
GO:0005524
GO:0005575
GO:0005576
GO:0005622
GO:0005737
GO:0005768
GO:0005783
GO:0005794
GO:0005886
GO:0005887
GO:0005911
GO:0006259
GO:0006464
GO:0006468
GO:0006629
GO:0007165
GO:0007169
GO:0007275
GO:0008150
GO:0008201
GO:0008283
GO:0008284
GO:0008543
GO:0009058
GO:0010628
GO:0010715
GO:0016020
GO:0016021
GO:0016301
GO:0016310
GO:0016477
GO:0016740
GO:0017134
GO:0018108
GO:0019216
GO:0030133
GO:0030198
GO:0031410
GO:0032991
GO:0033674
GO:0034641
GO:0040011
GO:0042592
GO:0042593
GO:0042632
GO:0043085
GO:0043167
GO:0043226
GO:0043235
GO:0044281
GO:0045862
GO:0046777
GO:0048856
GO:0048870
GO:0051897
GO:0055062
GO:0070374
GO:0070857
GO:2000573
ILMN_1730355
ILMN_2241412
ILMN_2410713
L03840_s_at
PH_hs_0010000
TC05001010.hg
g13112051_3p_at
g6739817_3p_a_at
Participant Of
hasComponent
Activated FGFR4 Y367C mutant [plasma membrane]
Other forms of this molecule
FGFR4 Y367C [plasma membrane]
FGFR4 N535K [plasma membrane]
FGFR4 V550E [plasma membrane]
FGFR4 V550L [plasma membrane]
FGFR4 N535D [plasma membrane]
p-5Y-FGFR4 V550E [plasma membrane]
p-5Y-FGFR4 N535K [plasma membrane]
p-5Y-FGFR4 V550L [plasma membrane]
p-5Y-FGFR4 N535D [plasma membrane]
FGFR4 [plasma membrane]
p-5Y-FGFR4 [plasma membrane]
Modified Residues
Name
L-tyrosine 367 replaced with L-cysteine
Coordinate
367
PsiMod
L-cysteine residue [MOD:00014]
A protein modification that effectively converts a source amino acid residue to an L-cysteine.
L-tyrosine removal [MOD:01649]
A protein modification that effectively removes or replaces an L-tyrosine.
Name
O4'-phospho-L-tyrosine at 642
Coordinate
642
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 643
Coordinate
643
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 719
Coordinate
719
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 754
Coordinate
754
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 764
Coordinate
764
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Disease
Name
Identifier
Synonyms
breast cancer
1612
malignant tumor of the breast, mammary cancer, malignant neoplasm of breast, mammary tumor, primary breast cancer, breast cancer, Ca breast - NOS, breast tumor
Cross References
RefSeq
NP_001278909.1
,
NP_998812.1
,
NP_002002.3
,
NP_075252.2
,
XP_005265895.1
ZINC - World Drugs
FGFR4_HUMAN
OpenTargets
ENSG00000160867
ZINC - FDA approved
FGFR4_HUMAN
ZINC - Substances
FGFR4_HUMAN
ZINC target
P22455
ZINC - Biogenic
FGFR4_HUMAN
PRO
P22455
PDB
6NVK
,
4TYE
,
6V9C
,
6J6Y
,
4TYG
,
6NVJ
,
4R6V
,
5NWZ
,
4QRC
,
4QQ5
,
6JPE
,
4TYI
,
4UXQ
,
1QCT
,
6IUO
,
4TYJ
,
6NVG
,
5JKG
,
4QQC
,
5NUD
,
4XCU
,
4QQJ
,
6JPJ
,
6NVI
,
5XFJ
,
4QQT
,
5XFF
,
6NVH
,
6IUP
ZINC - Investigational
FGFR4_HUMAN
GeneCards
P22455
HPA
ENSG00000160867-FGFR4
Ensembl
ENSG00000160867
,
ENSP00000292408
,
ENST00000502906
,
ENSP00000424960
,
ENST00000292408
,
ENST00000393637
,
ENSP00000377254
Orphanet
24538
ZINC - Predictions - Purchasable
FGFR4_HUMAN
HMDB Protein
HMDBP01234
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