Reactome | p5Y-FGFR4 Y367C mutant [plasma membrane]

p5Y-FGFR4 Y367C mutant [plasma membrane]

Stable Identifier

R-HSA-2011873

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

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External Reference Information

External Reference

UniProt:P22455 FGFR4

Gene Names

FGFR4, JTK2, TKF

Chain

signal peptide:1-21, chain:22-802

Reference Genes

BioGPS Gene:2264 FGFR4

COSMIC (genes):FGFR4 FGFR4

CTD Gene:2264 FGFR4

dbSNP Gene:2264 FGFR4

ENSEMBL:ENSG00000160867.15 FGFR4

HGNC:3691 FGFR4

KEGG Gene (Homo sapiens):2264 FGFR4

Monarch:2264 FGFR4

NCBI Gene:2264 FGFR4

OMIM:134935 FGFR4

UCSC:P22455 FGFR4

Reference Transcript

Other Identifiers

0000110440

0001090372

0005290176

11735873_a_at

11740240_a_at

11744657_x_at

11752172_a_at

11753528_a_at

11757181_x_at

1291_s_at

1554962_PM_a_at

1554962_a_at

16992957

204579_PM_at

204579_at

211237_PM_s_at

211237_s_at

2264

2842912

2842913

2842914

2842915

2842916

2842918

2842920

2842922

2842923

2842924

2842926

2842928

2842930

2842931

2842932

2842933

2842934

2842935

2842936

2842938

2842939

2842941

2842943

2842944

8110265

A_14_P131381

A_23_P92754

GO:0000166

GO:0004672

GO:0004713

GO:0004714

GO:0005007

GO:0005515

GO:0005524

GO:0005576

GO:0005622

GO:0005737

GO:0005768

GO:0005783

GO:0005794

GO:0005886

GO:0005887

GO:0005911

GO:0006468

GO:0006629

GO:0007169

GO:0008201

GO:0008284

GO:0008543

GO:0010628

GO:0010715

GO:0016020

GO:0016021

GO:0016301

GO:0016310

GO:0016477

GO:0016740

GO:0017134

GO:0018108

GO:0019216

GO:0023052

GO:0030133

GO:0030198

GO:0031410

GO:0032991

GO:0033674

GO:0036211

GO:0042593

GO:0042632

GO:0043085

GO:0043226

GO:0043235

GO:0045862

GO:0046777

GO:0048870

GO:0055062

GO:0060089

GO:0070374

GO:0070857

GO:0071495

GO:0140096

GO:2000573

HMNXSV003054104

ILMN_1730355

ILMN_2241412

ILMN_2410713

L03840_s_at

PH_hs_0010000

TC05001010.hg

g13112051_3p_at

g6739817_3p_a_at

Participates

as a component of

Activated FGFR4 Y367C mutant [plasma membrane] (Homo sapiens)

Other forms of this molecule

FGFR4 Y367C [plasma membrane]

FGFR4 N535K [plasma membrane]

FGFR4 V550E [plasma membrane]

FGFR4 V550L [plasma membrane]

FGFR4 N535D [plasma membrane]

p-5Y-FGFR4 V550E [plasma membrane]

p-5Y-FGFR4 N535K [plasma membrane]

p-5Y-FGFR4 V550L [plasma membrane]

p-5Y-FGFR4 N535D [plasma membrane]

FGFR4 [plasma membrane]

p-5Y-FGFR4 [plasma membrane]

Modified Residues

Name

L-tyrosine 367 replaced with L-cysteine

Coordinate

367

PsiMod

L-tyrosine removal [MOD:01649]

A protein modification that effectively removes or replaces an L-tyrosine.

L-cysteine residue [MOD:00014]

A protein modification that effectively converts a source amino acid residue to an L-cysteine.

Name

O4'-phospho-L-tyrosine at 642

Coordinate

642

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 643

Coordinate

643

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 719

Coordinate

719

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 754

Coordinate

754

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 764

Coordinate

764

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Disease

Name	Identifier	Synonyms
breast cancer	DOID:1612	malignant tumor of the breast, mammary cancer, malignant neoplasm of breast, mammary tumor, primary breast cancer, breast cancer, Ca breast - NOS, breast tumor

Cross References

RefSeq

NP_002002.3, NP_075252.2, XP_005265895.1, NP_001278909.1, NP_998812.1

ZINC - World Drugs

FGFR4_HUMAN

Guide to Pharmacology - Targets

1811

OpenTargets

ENSG00000160867

ZINC - FDA approved

FGFR4_HUMAN

ZINC - Substances

FGFR4_HUMAN

ZINC target

P22455

ZINC - Biogenic

FGFR4_HUMAN

PRO

P22455

PDB

7VJL, 7WCW, 4QQJ, 7WCT, 7V29, 6JPE, 6YI8, 4TYE, 6JPJ, 6NVG, 4QQT, 7WCX, 4R6V, 4TYG, 5JKG, 6NVH, 5NUD, 7F3M, 6IUO, 4UXQ, 7N1J, 4TYI, 5XFF, 4QRC, 4XCU, 6NVI, 4QQ5, 6IUP, 7DTZ, 6V9C, 4TYJ, 5XFJ, 6NVJ, 4QQC, 5NWZ, 6J6Y, 6NVK

ZINC - Investigational

FGFR4_HUMAN

GeneCards

P22455

HPA

ENSG00000160867-FGFR4

Ensembl

ENSP00000424960, ENST00000292408, ENST00000502906, ENSP00000292408, ENSP00000377254, ENST00000393637, ENSG00000160867

Pharos - Targets

P22455

ZINC - Predictions - Purchasable

FGFR4_HUMAN

Orphanet

24538

HMDB Protein

HMDBP01234

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P11362 FGFR1	9	FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853241) FGFR1 K656E [plasma membrane] (R-HSA-1614373) FGFR1 N546K [plasma membrane] (R-HSA-1614377) FGFR1 R576W [plasma membrane] (R-HSA-2011844) p-6Y FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853142) p-8Y-FGFR1 K656E [plasma membrane] (R-HSA-2023356) p-8Y-FGFR1 N546K [plasma membrane] (R-HSA-2023358) p-8Y- FGFR1 R576W [plasma membrane] (R-HSA-2023361) FGFR1 [plasma membrane] (R-HSA-9756433)	0.539	3
UniProt:Q06124 PTPN11	4	p-Y546-PTPN11 [cytosol] (R-HSA-1369081) PTPN11 [nucleoplasm] (R-HSA-8937745) PTPN11 [cytosol] (R-HSA-162563) p-Y546,Y584-PTPN11 [cytosol] (R-HSA-162573)	0.519	2
UniProt:P07949 RET	2	RET [plasma membrane] (R-HSA-8853797) p-5Y-RET [plasma membrane] (R-HSA-8854162)	0.499	2

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