Reactome | FRS2 [plasma membrane]

FRS2 [plasma membrane]

Stable Identifier

R-HSA-170963

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

FRS2-alpha

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External Reference Information

External Reference

UniProt:Q8WU20 FRS2

Gene Names

FRS2

Chain

initiator methionine:1, chain:2-508

Reference Genes

BioGPS Gene:10818 FRS2

COSMIC (genes):FRS2 FRS2

CTD Gene:10818 FRS2

dbSNP Gene:10818 FRS2

ENSEMBL:ENSG00000166225.9 FRS2

HGNC:16971 FRS2

KEGG Gene (Homo sapiens):10818 FRS2

Monarch:10818 FRS2

NCBI Gene:10818 FRS2

OMIM:607743 FRS2

UCSC:Q8WU20 FRS2

Reference Transcript

Other Identifiers

0006040575

10818

11743789_a_at

11743790_a_at

11743791_s_at

11750929_a_at

16753943

221308_PM_at

221308_at

226045_PM_at

226045_at

238486_PM_at

238486_at

3421580

3421599

3421600

3421601

3421609

3421614

3421615

3421616

3421617

3421618

3421620

3421622

3421623

3421624

3421625

3421626

3421627

3421628

3421629

50853_at

63302_at

69396_at

69399_g_at

69401_at

7957043

A_14_P139031

A_23_P430785

A_33_P3364112

GE61785

GE79952

GO:0001702

GO:0001759

GO:0002088

GO:0003281

GO:0005068

GO:0005104

GO:0005168

GO:0005515

GO:0005622

GO:0005737

GO:0005829

GO:0005886

GO:0005887

GO:0005911

GO:0005912

GO:0007169

GO:0007185

GO:0007186

GO:0007405

GO:0008543

GO:0008595

GO:0012501

GO:0012505

GO:0016020

GO:0019211

GO:0022414

GO:0023052

GO:0030154

GO:0030900

GO:0042981

GO:0043410

GO:0044344

GO:0046619

GO:0048856

GO:0050678

GO:0050790

GO:0060090

GO:0060527

GO:0070307

GO:0070372

GO:0098772

GO:1904707

GO:2000726

HMNXSV003042492

Hs.202404.0.A1_3p_at

Hs.283705.0.A1_3p_at

ILMN_1703222

ILMN_1906967

ILMN_1911605

ILMN_2335893

PH_hs_0023008

PH_hs_0036448

TC12000614.hg

g5730056_3p_at

Participates

as a member of

as a component of

as an input of

Other forms of this molecule

p-Y-FRS2 [cytosol]

FRS2 [cytosol]

p-6Y-FRS2 [cytosol]

p-8T-FRS2 [plasma membrane]

p-6Y-FRS2 [plasma membrane]

Inferred To

Dmel\CG13398 [plasma membrane] (Drosophila melanogaster)

Frs2 [plasma membrane] (Mus musculus)

FRS2 [plasma membrane] (Bos taurus)

FRS2 [plasma membrane] (Canis familiaris)

FRS2 [plasma membrane] (Danio rerio)

FRS2 [plasma membrane] (Gallus gallus)

FRS2 [plasma membrane] (Rattus norvegicus)

FRS2 [plasma membrane] (Sus scrofa)

frs2 [plasma membrane] (Xenopus tropicalis)

rog-1 [plasma membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001265282.1, NP_001265284.1, XP_016874207.1, NP_006645.3, NP_001265285.1, XP_016874208.1, NP_001265280.1, XP_016874206.1, NP_001265286.1, NP_001036020.1, NP_001265283.1

OpenTargets

ENSG00000166225

HPA

ENSG00000166225-FRS2

GeneCards

Q8WU20

Ensembl

ENST00000549921, ENST00000550389, ENSP00000381083, ENST00000397997, ENSG00000166225, ENSP00000447241, ENSP00000450048

PRO

Q8WU20

Pharos - Targets

Q8WU20

PDB

2MFQ, 1XR0

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q06124 PTPN11	4	p-Y546-PTPN11 [cytosol] (R-HSA-1369081) PTPN11 [nucleoplasm] (R-HSA-8937745) PTPN11 [cytosol] (R-HSA-162563) p-Y546,Y584-PTPN11 [cytosol] (R-HSA-162573)	0.714	5
UniProt:P11362 FGFR1	9	FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853241) FGFR1 K656E [plasma membrane] (R-HSA-1614373) FGFR1 N546K [plasma membrane] (R-HSA-1614377) FGFR1 R576W [plasma membrane] (R-HSA-2011844) p-6Y FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853142) p-8Y-FGFR1 K656E [plasma membrane] (R-HSA-2023356) p-8Y-FGFR1 N546K [plasma membrane] (R-HSA-2023358) p-8Y- FGFR1 R576W [plasma membrane] (R-HSA-2023361) FGFR1 [plasma membrane] (R-HSA-9756433)	0.569	3

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