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FGFR4 Y367C [plasma membrane]
Stable Identifier
R-HSA-1614439
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by FGFR in disease (Homo sapiens)
Signaling by FGFR4 in disease (Homo sapiens)
FGFR4 mutant receptor activation (Homo sapiens)
Autocatalytic phosphorylation of FGFR4 Y367C mutant (Homo sapiens)
FGFR4 Y367C mutant dimer [plasma membrane] (Homo sapiens)
FGFR4 Y367C [plasma membrane] (Homo sapiens)
Constitutive dimerization of FGFR4 Y367C mutant (Homo sapiens)
FGFR4 Y367C [plasma membrane] (Homo sapiens)
FGFR4 Y367C mutant dimer [plasma membrane] (Homo sapiens)
FGFR4 Y367C [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P22455 FGFR4
Gene Names
FGFR4, JTK2, TKF
Chain
signal peptide:1-21, chain:22-802
Reference Genes
BioGPS Gene:2264 FGFR4
COSMIC (genes):FGFR4 FGFR4
CTD Gene:2264 FGFR4
dbSNP Gene:2264 FGFR4
ENSEMBL:ENSG00000160867 FGFR4
HGNC:3691 FGFR4
KEGG:hsa:2264 FGFR4
Monarch:2264 FGFR4
NCBI Gene:2264 FGFR4
OMIM:134935 FGFR4
UCSC:P22455 FGFR4
Reference Transcript
RefSeq:NM_002011.4 FGFR4
RefSeq:NM_213647.2 FGFR4
RefSeq:XM_005265838.3 FGFR4
RefSeq:NM_022963.3 FGFR4
RefSeq:NM_001291980.1 FGFR4
Other Identifiers
11735873_a_at
11740240_a_at
11744657_x_at
11752172_a_at
11753528_a_at
11757181_x_at
11762799_a_at
1291_s_at
1554961_PM_at
1554961_at
1554962_PM_a_at
1554962_a_at
16992957
204579_PM_at
204579_at
211237_PM_s_at
211237_s_at
2264
2842910
2842912
2842913
2842914
2842915
2842916
2842918
2842919
2842920
2842921
2842922
2842923
2842924
2842925
2842926
2842928
2842929
2842930
2842931
2842932
2842933
2842934
2842935
2842936
2842937
2842938
2842939
2842940
2842941
2842943
2842944
8110265
A_14_P131381
A_14_P138290
A_23_P92754
GE57553
GO:0003824
GO:0004672
GO:0004713
GO:0004714
GO:0005007
GO:0005515
GO:0005524
GO:0005576
GO:0005737
GO:0005768
GO:0005783
GO:0005794
GO:0005886
GO:0005911
GO:0006468
GO:0008201
GO:0008284
GO:0008543
GO:0010628
GO:0010715
GO:0016020
GO:0016477
GO:0016740
GO:0017134
GO:0018108
GO:0019216
GO:0030133
GO:0031410
GO:0042593
GO:0042632
GO:0043085
GO:0043226
GO:0043235
GO:0045862
GO:0046777
GO:0048870
GO:0055062
GO:0060089
GO:0070374
GO:0070857
GO:0140096
GO:2000573
HMNXSV003054104
Hs2.165950.4.S1_3p_at
ILMN_1730355
ILMN_2241412
ILMN_2410713
L03840_s_at
PH_hs_0010000
TC05001010.hg
g13112051_3p_at
g6739817_3p_a_at
Participates
as a component of
FGFR4 Y367C mutant dimer [plasma membrane] (Homo sapiens)
as an input of
Constitutive dimerization of FGFR4 Y367C mutant (Homo sapiens)
Other forms of this molecule
p-5Y-FGFR4 [plasma membrane]
FGFR4 [plasma membrane]
p5Y-FGFR4 Y367C mutant [plasma membrane]
p-5Y-FGFR4 N535D [plasma membrane]
p-5Y-FGFR4 V550L [plasma membrane]
p-5Y-FGFR4 N535K [plasma membrane]
p-5Y-FGFR4 V550E [plasma membrane]
FGFR4 N535D [plasma membrane]
FGFR4 V550L [plasma membrane]
FGFR4 V550E [plasma membrane]
FGFR4 N535K [plasma membrane]
Modified Residues
Name
L-tyrosine 367 replaced with L-cysteine
Coordinate
367
PsiMod
L-tyrosine removal [MOD:01649]
A protein modification that effectively removes or replaces an L-tyrosine.
L-cysteine residue [MOD:00014]
A protein modification that effectively converts a source amino acid residue to an L-cysteine.
Disease
Name
Identifier
Synonyms
breast cancer
DOID:1612
malignant tumor of the breast, mammary cancer, malignant neoplasm of breast, mammary tumor, primary breast cancer, breast cancer, Ca breast - NOS, breast tumor
Cross References
RefSeq
NP_002002.3
,
NP_998812.1
,
XP_005265895.1
,
NP_001278909.1
,
NP_075252.2
ZINC - World Drugs
FGFR4_HUMAN
Guide to Pharmacology - Targets
1811
OpenTargets
ENSG00000160867
ENSEMBL
ENSP00000377254
,
ENST00000502906
,
ENST00000393637
,
ENSP00000292408
,
ENST00000292408
,
ENSP00000424960
ZINC - FDA approved
FGFR4_HUMAN
ZINC - Substances
FGFR4_HUMAN
ZINC - Biogenic
FGFR4_HUMAN
ZINC target
P22455
PRO
P22455
PDB
4TYJ
,
7DTZ
,
7N1J
,
7F3M
,
4QQ5
,
4TYI
,
4TYG
,
7WCW
,
7YC1
,
7YC3
,
5JKG
,
4QQT
,
7VJL
,
6IUP
,
6NVH
,
7TYD
,
4R6V
,
4QQC
,
7YBP
,
6NVI
,
4QQJ
,
4TYE
,
6JPE
,
6IUO
,
6YI8
,
7WCT
,
8XLQ
,
6NVG
,
7YSW
,
5NUD
,
6NVK
,
6NVJ
,
4XCU
,
5XFJ
,
7V29
,
5NWZ
,
5XFF
,
6V9C
,
6J6Y
,
4UXQ
,
7WCX
,
7YBX
,
6JPJ
,
4QRC
,
7YBO
ZINC - Investigational
FGFR4_HUMAN
HPA
ENSG00000160867-FGFR4
Pharos - Targets
P22455
ZINC - Predictions - Purchasable
FGFR4_HUMAN
HMDB Protein
HMDBP01234
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P11362 FGFR1
9
FGFR1 [plasma membrane]
(R-HSA-9756433)
p-8Y- FGFR1 R576W [plasma membrane]
(R-HSA-2023361)
p-8Y-FGFR1 N546K [plasma membrane]
(R-HSA-2023358)
p-8Y-FGFR1 K656E [plasma membrane]
(R-HSA-2023356)
p-6Y-FGFR1(22-763):TACC1(571-805) fusion [plasma membrane]
(R-HSA-8853142)
FGFR1 R576W [plasma membrane]
(R-HSA-2011844)
FGFR1 N546K [plasma membrane]
(R-HSA-1614377)
FGFR1 K656E [plasma membrane]
(R-HSA-1614373)
FGFR1(22-763):TACC1(571-805) fusion [plasma membrane]
(R-HSA-8853241)
0.539
3
UniProt:Q6ZMH5 SLC39A5
1
SLC39A5 [plasma membrane]
(R-HSA-442360)
0.527
2
UniProt:P55899 FCGRN
0.527
2
UniProt:Q96G30 MRAP2
0.527
2
UniProt:Q3MIR4 CC50B
0.527
2
UniProt:Q06124 PTPN11
4
p-Y542,Y580-PTPN11 [cytosol]
(R-HSA-162573)
PTPN11 [cytosol]
(R-HSA-162563)
PTPN11 [nucleoplasm]
(R-HSA-8937745)
p-Y542-PTPN11 [cytosol]
(R-HSA-1369081)
0.519
2
UniProt:P07949 RET
2
RET [plasma membrane]
(R-HSA-8853797)
p-5Y-RET [plasma membrane]
(R-HSA-8854162)
0.499
2
UniProt:P05230 FGF1
1
FGF1 [extracellular region]
(R-HSA-189856)
0.483
2
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