Reactome | p-Y223,Y248-PDCD1 [plasma membrane]

p-Y223,Y248-PDCD1 [plasma membrane]

Stable Identifier

R-HSA-389736

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Phosphorylated PD-1

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q15116 PDCD1

Gene Names

PDCD1, PD1

Chain

signal peptide:1-24, chain:25-288

Reference Genes

BioGPS Gene:5133 PDCD1

COSMIC (genes):PDCD1 PDCD1

CTD Gene:5133 PDCD1

dbSNP Gene:5133 PDCD1

ENSEMBL:ENSG00000188389 PDCD1

HGNC:8760 PDCD1

KEGG:hsa:5133 PDCD1

Monarch:5133 PDCD1

NCBI Gene:5133 PDCD1

OMIM:600244 PDCD1

UCSC:Q15116 PDCD1

Reference Transcript

RefSeq:NM_005018.2 PDCD1

Other Identifiers

11734446_at

11734447_x_at

11734448_a_at

11751541_a_at

16910536

207634_PM_at

207634_at

33085_at

4046276

4046277

4046280

4046281

4046282

4046283

4046284

4046285

4046286

4046287

4046288

4046289

4046290

4046291

4046292

4046293

5133

8060294

A_23_P136405

GE59311

GO:0001783

GO:0002250

GO:0002376

GO:0002644

GO:0002841

GO:0002903

GO:0005515

GO:0005886

GO:0006915

GO:0006959

GO:0009897

GO:0012501

GO:0016020

GO:0038023

GO:0050776

GO:0050777

GO:0050868

GO:0060089

GO:0070234

GO:1902482

HMNXSV003031653

HMNXSV003056109

PH_hs_0027896

TC02002960.hg

U64863_at

g4826889_3p_at

Participates

as a component of

p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Homo sapiens)

Other forms of this molecule

PDCD1 [plasma membrane]

Inferred To

phospho-p-Y223,Y248-PDCD1 [plasma membrane] (Bos taurus)

phospho-Pdcd1 [plasma membrane] (Mus musculus)

phospho-Pdcd1 [plasma membrane] (Rattus norvegicus)

phospho-PDCD1 [plasma membrane] (Canis familiaris)

phospho-PDCD1 [plasma membrane] (Gallus gallus)

phospho-PDCD1 [plasma membrane] (Sus scrofa)

Modified Residues

Name

O4'-phospho-L-tyrosine at 223

Coordinate

223

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 248

Coordinate

248

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

Guide to Pharmacology - Targets

2760

OpenTargets

ENSG00000188389

ENSEMBL

ENSG00000188389, ENSP00000480684, ENST00000334409, ENSG00000276977, ENSP00000335062, ENST00000618185

HPA

ENSG00000188389-PDCD1

GeneCards

PDCD1

PRO

Q15116

Pharos - Targets

Q15116

GlyGen

Q15116

Orphanet

PDCD1

PDB

7VUX, 5JXE, 4ZQK, 6R5G, 6HIG, 5WT9, 6JBT, 5IUS, 8U31, 7WVM, 6J15, 7CU5, 5B8C, 2M2D, 8EQ6, 6UMT, 6ROY, 6UMU, 6K0Y, 7WSL, 6ROZ, 3RRQ, 6UMV, 6XKR, 6J14, 7E9B, 8U32, 8AS0, 7BXA, 6JJP, 8GY5, 5GGS, 5GGR, 7CGW

Interactors (23)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NZQ7 CD274	1	CD274 [plasma membrane] (R-HSA-3211776)	0.802	17
UniProt:Q9BQ51 PDCD1LG2	1	PDCD1LG2 [plasma membrane] (R-HSA-3211774)	0.74	14
UniProt:Q06124 PTPN11	4	p-Y542,Y580-PTPN11 [cytosol] (R-HSA-162573) PTPN11 [cytosol] (R-HSA-162563) PTPN11 [nucleoplasm] (R-HSA-8937745) p-Y542-PTPN11 [cytosol] (R-HSA-1369081)	0.602	3
UniProt:Q9NZQ7-1 CD274			0.558	2
UniProt:Q9UK39 NOCT	1	CCRN4L [nucleoplasm] (R-HSA-508391)	0.527	2
UniProt:P16260 SLC25A16	1	SLC25A16 [mitochondrial inner membrane] (R-HSA-199229)	0.527	2
UniProt:Q8NE86 MCU	1	MCU [mitochondrial inner membrane] (R-HSA-8949184)	0.527	2
UniProt:Q0P651 ABD18			0.527	2
UniProt:Q9BWM7 SFXN3			0.527	2
UniProt:P43378 PTPN9	1	PTPN9 [nucleoplasm] (R-HSA-9008907)	0.527	2
UniProt:Q8NCW6 GALNT11	1	GALNT11 [Golgi membrane] (R-HSA-913687)	0.527	2
UniProt:A6ZKI3 RTL8C			0.527	2
UniProt:Q96A46 SLC25A28	1	SLC25A28 [mitochondrial inner membrane] (R-HSA-1362394)	0.527	2
UniProt:Q8WUD6 CHPT1	1	CHPT1 [Golgi membrane] (R-HSA-1498754)	0.527	2
UniProt:Q9BV35 SCMC3			0.527	2
UniProt:Q969H6 POP5	1	POP5 [nucleoplasm] (R-HSA-5696783)	0.527	2
UniProt:Q96HW7 INTS4	1	INTS4 [nucleoplasm] (R-HSA-6807462)	0.527	2
UniProt:Q8IWF6 DENND6A	1	DENND6A [cytosol] (R-HSA-8876587)	0.527	2
UniProt:Q96AG3 S2546			0.527	2
UniProt:Q9UIA9 XPO7			0.527	2
UniProt:Q9Y619 SLC25A15	1	SLC25A15 [mitochondrial inner membrane] (R-HSA-70618)	0.527	2
UniProt:Q92520 FAM3C	2	FAM3C [extracellular region] (R-HSA-8848922) FAM3C [platelet dense granule lumen] (R-HSA-8848884)	0.527	2
UniProt:P36894 BMPR1A	2	BMPR1A [plasma membrane] (R-HSA-201480) p-4S-BMPR1A [plasma membrane] (R-HSA-201448)	0.527	2

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