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p-Y223,Y248-PDCD1 [plasma membrane]
Stable Identifier
R-HSA-389736
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Phosphorylated PD-1
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Regulation of T cell activation by CD28 family (Homo sapiens)
Co-inhibition by PD-1 (Homo sapiens)
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Homo sapiens)
PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
p-Y223,Y248-PDCD1 [plasma membrane] (Homo sapiens)
Interaction of SHP-1 or SHP-2 with phospho PD-1 (Homo sapiens)
PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
p-Y223,Y248-PDCD1 [plasma membrane] (Homo sapiens)
p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
p-Y223,Y248-PDCD1 [plasma membrane] (Homo sapiens)
Phosphorylation of PD-1 (Homo sapiens)
p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
p-Y223,Y248-PDCD1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15116 PDCD1
Gene Names
PDCD1, PD1
Chain
signal peptide:1-24, chain:25-288
Reference Genes
BioGPS Gene:5133 PDCD1
COSMIC (genes):PDCD1 PDCD1
CTD Gene:5133 PDCD1
dbSNP Gene:5133 PDCD1
ENSEMBL:ENSG00000188389 PDCD1
HGNC:8760 PDCD1
KEGG:hsa:5133 PDCD1
Monarch:5133 PDCD1
NCBI Gene:5133 PDCD1
OMIM:600244 PDCD1
UCSC:Q15116 PDCD1
Reference Transcript
RefSeq:NM_005018.2 PDCD1
Other Identifiers
11734446_at
11734447_x_at
11734448_a_at
11751541_a_at
16910536
207634_PM_at
207634_at
33085_at
4046276
4046277
4046280
4046281
4046282
4046283
4046284
4046285
4046286
4046287
4046288
4046289
4046290
4046291
4046292
4046293
5133
8060294
A_23_P136405
GE59311
GO:0001783
GO:0002250
GO:0002376
GO:0002644
GO:0002841
GO:0002903
GO:0005515
GO:0005886
GO:0006915
GO:0006959
GO:0009897
GO:0012501
GO:0016020
GO:0038023
GO:0050776
GO:0050777
GO:0050868
GO:0060089
GO:0070234
GO:1902482
HMNXSV003031653
HMNXSV003056109
PH_hs_0027896
TC02002960.hg
U64863_at
g4826889_3p_at
Participates
as a component of
p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
Other forms of this molecule
PDCD1 [plasma membrane]
Inferred To
phospho-p-Y223,Y248-PDCD1 [plasma membrane]
(Bos taurus)
phospho-Pdcd1 [plasma membrane]
(Mus musculus)
phospho-Pdcd1 [plasma membrane]
(Rattus norvegicus)
phospho-PDCD1 [plasma membrane]
(Canis familiaris)
phospho-PDCD1 [plasma membrane]
(Gallus gallus)
phospho-PDCD1 [plasma membrane]
(Sus scrofa)
Modified Residues
Name
O4'-phospho-L-tyrosine at 223
Coordinate
223
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 248
Coordinate
248
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
Guide to Pharmacology - Targets
2760
OpenTargets
ENSG00000188389
ENSEMBL
ENSG00000188389
,
ENSP00000480684
,
ENST00000334409
,
ENSG00000276977
,
ENSP00000335062
,
ENST00000618185
HPA
ENSG00000188389-PDCD1
GeneCards
PDCD1
PRO
Q15116
Pharos - Targets
Q15116
GlyGen
Q15116
Orphanet
PDCD1
PDB
7VUX
,
5JXE
,
4ZQK
,
6R5G
,
6HIG
,
5WT9
,
6JBT
,
5IUS
,
8U31
,
7WVM
,
6J15
,
7CU5
,
5B8C
,
2M2D
,
8EQ6
,
6UMT
,
6ROY
,
6UMU
,
6K0Y
,
7WSL
,
6ROZ
,
3RRQ
,
6UMV
,
6XKR
,
6J14
,
7E9B
,
8U32
,
8AS0
,
7BXA
,
6JJP
,
8GY5
,
5GGS
,
5GGR
,
7CGW
Interactors (23)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NZQ7 CD274
1
CD274 [plasma membrane]
(R-HSA-3211776)
0.802
17
UniProt:Q9BQ51 PDCD1LG2
1
PDCD1LG2 [plasma membrane]
(R-HSA-3211774)
0.74
14
UniProt:Q06124 PTPN11
4
p-Y542,Y580-PTPN11 [cytosol]
(R-HSA-162573)
PTPN11 [cytosol]
(R-HSA-162563)
PTPN11 [nucleoplasm]
(R-HSA-8937745)
p-Y542-PTPN11 [cytosol]
(R-HSA-1369081)
0.602
3
UniProt:Q9NZQ7-1 CD274
0.558
2
UniProt:Q9UK39 NOCT
1
CCRN4L [nucleoplasm]
(R-HSA-508391)
0.527
2
UniProt:P16260 SLC25A16
1
SLC25A16 [mitochondrial inner membrane]
(R-HSA-199229)
0.527
2
UniProt:Q8NE86 MCU
1
MCU [mitochondrial inner membrane]
(R-HSA-8949184)
0.527
2
UniProt:Q0P651 ABD18
0.527
2
UniProt:Q9BWM7 SFXN3
0.527
2
UniProt:P43378 PTPN9
1
PTPN9 [nucleoplasm]
(R-HSA-9008907)
0.527
2
UniProt:Q8NCW6 GALNT11
1
GALNT11 [Golgi membrane]
(R-HSA-913687)
0.527
2
UniProt:A6ZKI3 RTL8C
0.527
2
UniProt:Q96A46 SLC25A28
1
SLC25A28 [mitochondrial inner membrane]
(R-HSA-1362394)
0.527
2
UniProt:Q8WUD6 CHPT1
1
CHPT1 [Golgi membrane]
(R-HSA-1498754)
0.527
2
UniProt:Q9BV35 SCMC3
0.527
2
UniProt:Q969H6 POP5
1
POP5 [nucleoplasm]
(R-HSA-5696783)
0.527
2
UniProt:Q96HW7 INTS4
1
INTS4 [nucleoplasm]
(R-HSA-6807462)
0.527
2
UniProt:Q8IWF6 DENND6A
1
DENND6A [cytosol]
(R-HSA-8876587)
0.527
2
UniProt:Q96AG3 S2546
0.527
2
UniProt:Q9UIA9 XPO7
0.527
2
UniProt:Q9Y619 SLC25A15
1
SLC25A15 [mitochondrial inner membrane]
(R-HSA-70618)
0.527
2
UniProt:Q92520 FAM3C
2
FAM3C [extracellular region]
(R-HSA-8848922)
FAM3C [platelet dense granule lumen]
(R-HSA-8848884)
0.527
2
UniProt:P36894 BMPR1A
2
BMPR1A [plasma membrane]
(R-HSA-201480)
p-4S-BMPR1A [plasma membrane]
(R-HSA-201448)
0.527
2
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