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CCKBR [plasma membrane]
Stable Identifier
R-HSA-388515
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Cholecystokinin type B receptor, RecName: Full=Gastrin/cholecystokinin type B receptor; Short=CCK-B receptor; Short=CCK-BR; AltName: Full=Cholecystokinin-2 receptor; Short=CCK2-R;
GN Name=CCKBR; Synonyms=CCKRB;
OS Homo sapiens, GASR_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Gastrin-CREB signalling pathway via PKC and MAPK (Homo sapiens)
Gastrin binds to CCK-B receptor (Homo sapiens)
CCKBR [plasma membrane] (Homo sapiens)
Gastrin:CCKBR [plasma membrane] (Homo sapiens)
CCKBR [plasma membrane] (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
CCKAR,CCKBR:CCK [plasma membrane] (Homo sapiens)
CCKAR,CCKBR [plasma membrane] (Homo sapiens)
CCKBR [plasma membrane] (Homo sapiens)
Gastrin:CCKBR [plasma membrane] (Homo sapiens)
CCKBR [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
CCKAR,CCKBR:CCK [plasma membrane] (Homo sapiens)
CCKAR,CCKBR [plasma membrane] (Homo sapiens)
CCKBR [plasma membrane] (Homo sapiens)
Gastrin:CCKBR [plasma membrane] (Homo sapiens)
CCKBR [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
CCKAR,CCKBR:CCK [plasma membrane] (Homo sapiens)
CCKAR,CCKBR [plasma membrane] (Homo sapiens)
CCKBR [plasma membrane] (Homo sapiens)
Gastrin:CCKBR [plasma membrane] (Homo sapiens)
CCKBR [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
CCKAR,CCKBR:CCK [plasma membrane] (Homo sapiens)
CCKAR,CCKBR [plasma membrane] (Homo sapiens)
CCKBR [plasma membrane] (Homo sapiens)
Gastrin:CCKBR [plasma membrane] (Homo sapiens)
CCKBR [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
CCKAR,CCKBR [plasma membrane] (Homo sapiens)
CCKBR [plasma membrane] (Homo sapiens)
CCKBR [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
CCKAR,CCKBR:CCK [plasma membrane] (Homo sapiens)
CCKAR,CCKBR [plasma membrane] (Homo sapiens)
CCKBR [plasma membrane] (Homo sapiens)
Gastrin:CCKBR [plasma membrane] (Homo sapiens)
CCKBR [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Cholecystokinin receptors bind cholecystokinin (Homo sapiens)
CCKAR,CCKBR [plasma membrane] (Homo sapiens)
CCKBR [plasma membrane] (Homo sapiens)
CCKAR,CCKBR:CCK [plasma membrane] (Homo sapiens)
CCKAR,CCKBR [plasma membrane] (Homo sapiens)
CCKBR [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P32239 CCKBR
Gene Names
CCKBR, CCKRB
Chain
chain:1-447
Reference Genes
BioGPS Gene:887 CCKBR
COSMIC (genes):CCKBR CCKBR
CTD Gene:887 CCKBR
dbSNP Gene:887 CCKBR
ENSEMBL:ENSG00000110148.10 CCKBR
HGNC:1571 CCKBR
KEGG Gene (Homo sapiens):887 CCKBR
Monarch:887 CCKBR
NCBI Gene:887 CCKBR
OMIM:118445 CCKBR
UCSC:P32239 CCKBR
Reference Transcript
RefSeq:XM_005253210.1 CCKBR
RefSeq:XM_017018516.1 CCKBR
RefSeq:NM_001318029.1 CCKBR
RefSeq:NM_176875.3 CCKBR
Other Identifiers
11730387_a_at
16721355
2083_at
210381_PM_s_at
210381_s_at
3318640
3318641
3318645
3318647
3318649
3318650
3318651
3318652
3318653
35923_at
7938090
887
A_14_P126583
A_23_P162010
D13305_at
GE57056
GO:0001696
GO:0004930
GO:0004951
GO:0005515
GO:0005886
GO:0007165
GO:0007166
GO:0007186
GO:0007200
GO:0007204
GO:0008284
GO:0015054
GO:0016020
GO:0016021
GO:0017046
GO:0022600
GO:0023052
GO:0031741
GO:0038188
GO:0045851
GO:0046935
GO:0048565
GO:0048732
GO:0048856
GO:0060089
GO:0098772
HMNXSV003042911
ILMN_1760088
PH_hs_0000029
TC11000129.hg
TC11002539.hg
g12653894_3p_a_at
Participates
as an input of
Gastrin binds to CCK-B receptor (Homo sapiens)
as a member of
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
CCKAR,CCKBR [plasma membrane] (Homo sapiens)
as a component of
Gastrin:CCKBR [plasma membrane] (Homo sapiens)
Inferred To
Cckbr [plasma membrane]
(Mus musculus)
Cckbr [plasma membrane]
(Rattus norvegicus)
CCKBR [plasma membrane]
(Bos taurus)
CCKBR [plasma membrane]
(Caenorhabditis elegans)
CCKBR [plasma membrane]
(Canis familiaris)
CCKBR [plasma membrane]
(Danio rerio)
CCKBR [plasma membrane]
(Gallus gallus)
cckbr [plasma membrane]
(Xenopus tropicalis)
nmur-1 [plasma membrane]
(Caenorhabditis elegans)
nmur-2 [plasma membrane]
(Caenorhabditis elegans)
dcar-1 [plasma membrane]
(Caenorhabditis elegans)
Homologues of CCKBR [plasma membrane]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_001304958.1
,
XP_005253267.1
,
NP_795344.1
,
XP_016874005.1
ZINC - World Drugs
GASR_HUMAN
Guide to Pharmacology - Targets
77
OpenTargets
ENSG00000110148
ZINC - Substances
GASR_HUMAN
ZINC - Biogenic
GASR_HUMAN
ZINC target
P32239
PRO
P32239
PDB
7F8W
,
7XOW
,
7F8V
,
1L4T
,
7XOX
ZINC - Investigational
GASR_HUMAN
ZINC - Metabolites
GASR_HUMAN
HPA
ENSG00000110148-CCKBR
GeneCards
P32239
Ensembl
ENSP00000435534
,
ENSG00000110148
,
ENST00000525462
,
ENST00000334619
,
ENSP00000335544
Pharos - Targets
P32239
ZINC - Predictions - Purchasable
GASR_HUMAN
HMDB Protein
HMDBP02559
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q06124 PTPN11
4
p-Y542-PTPN11 [cytosol]
(R-HSA-1369081)
PTPN11 [nucleoplasm]
(R-HSA-8937745)
PTPN11 [cytosol]
(R-HSA-162563)
p-Y542,Y580-PTPN11 [cytosol]
(R-HSA-162573)
0.623
5
UniProt:Q9P121 NTM
2
cleaved GPI-NTM [extracellular region]
(R-HSA-8941007)
GPI-NTM [plasma membrane]
(R-HSA-8940706)
0.556
3
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