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p-6Y-FRS2 [cytosol]
Stable Identifier
R-HSA-190355
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Phospho-FRS2-alpha
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Signalling to ERKs (Homo sapiens)
Prolonged ERK activation events (Homo sapiens)
Frs2-mediated activation (Homo sapiens)
(Frs2)C3G stimulates nucleotide exchange on Rap1 (Homo sapiens)
Active TrkA receptor:p-FRS2:CRKL:RAPGEF1 [endosome membrane] (Homo sapiens)
Active TrkA receptor:p-FRS2:CRKL complex [endosome membrane] (Homo sapiens)
p-6Y-FRS2 [cytosol] (Homo sapiens)
FRS2 is phosphorylated by active TrkA receptor (Homo sapiens)
Active TrkA receptor:p-FRS2 complex [endosome membrane] (Homo sapiens)
p-6Y-FRS2 [cytosol] (Homo sapiens)
p-FRS2 binds CRKL (Homo sapiens)
Active TrkA receptor:p-FRS2 complex [endosome membrane] (Homo sapiens)
p-6Y-FRS2 [cytosol] (Homo sapiens)
Active TrkA receptor:p-FRS2:CRKL complex [endosome membrane] (Homo sapiens)
p-6Y-FRS2 [cytosol] (Homo sapiens)
p-FRS2:CRKL binds C3G (Homo sapiens)
Active TrkA receptor:p-FRS2:CRKL complex [endosome membrane] (Homo sapiens)
p-6Y-FRS2 [cytosol] (Homo sapiens)
Active TrkA receptor:p-FRS2:CRKL:RAPGEF1 [endosome membrane] (Homo sapiens)
Active TrkA receptor:p-FRS2:CRKL complex [endosome membrane] (Homo sapiens)
p-6Y-FRS2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8WU20 FRS2
Gene Names
FRS2
Chain
initiator methionine:, chain:2-508
Reference Genes
BioGPS Gene:10818 FRS2
COSMIC (genes):FRS2 FRS2
CTD Gene:10818 FRS2
dbSNP Gene:10818 FRS2
ENSEMBL:ENSG00000166225 FRS2
ENSEMBL_homo_sapiens_GENE:ENSG00000166225.9 FRS2
HGNC:16971 FRS2
KEGG Gene (Homo sapiens):10818 FRS2
Monarch:10818 FRS2
NCBI Gene:10818 FRS2
OMIM:607743 FRS2
UCSC:Q8WU20 FRS2
Reference Transcript
RefSeq:NM_001042555.2 FRS2
RefSeq:NM_001278354.1 FRS2
RefSeq:NM_001278357.1 FRS2
RefSeq:XM_017018718.1 FRS2
RefSeq:NM_001278353.1 FRS2
RefSeq:NM_001278356.1 FRS2
RefSeq:XM_017018717.1 FRS2
RefSeq:NM_001278351.1 FRS2
RefSeq:NM_001278355.1 FRS2
RefSeq:NM_006654.4 FRS2
RefSeq:XM_017018719.1 FRS2
Other Identifiers
10818
11743789_a_at
11743790_a_at
11743791_s_at
11750929_a_at
16753943
221308_PM_at
221308_at
226045_PM_at
226045_at
238486_PM_at
238486_at
3421580
3421599
3421600
3421601
3421609
3421614
3421615
3421616
3421617
3421618
3421620
3421622
3421623
3421624
3421625
3421626
3421627
3421628
3421629
50853_at
63302_at
69396_at
69399_g_at
69401_at
7957043
A_14_P139031
A_23_P430785
A_33_P3364112
GE61785
GE79952
GO:0001702
GO:0001759
GO:0002088
GO:0003281
GO:0005068
GO:0005104
GO:0005168
GO:0005515
GO:0005737
GO:0005829
GO:0005886
GO:0005911
GO:0005912
GO:0007169
GO:0007185
GO:0007186
GO:0007405
GO:0008543
GO:0008595
GO:0012501
GO:0012505
GO:0016020
GO:0019211
GO:0022414
GO:0023052
GO:0030154
GO:0030900
GO:0042981
GO:0043410
GO:0044344
GO:0046619
GO:0048856
GO:0050678
GO:0060090
GO:0060527
GO:0070307
GO:0070372
GO:0098772
GO:1904707
GO:2000726
HMNXSV003042492
Hs.202404.0.A1_3p_at
Hs.283705.0.A1_3p_at
ILMN_1703222
ILMN_1911605
ILMN_2335893
PH_hs_0023008
PH_hs_0036448
TC12000614.hg
g5730056_3p_at
Participates
as a component of
Active TrkA receptor:p-FRS2 complex [endosome membrane] (Homo sapiens)
Active TrkA receptor:p-FRS2:CRKL complex [endosome membrane] (Homo sapiens)
Other forms of this molecule
p-Y-FRS2 [cytosol]
FRS2 [cytosol]
p-8T-FRS2 [plasma membrane]
FRS2 [plasma membrane]
p-6Y-FRS2 [plasma membrane]
Inferred To
phospho-Frs2 [cytosol]
(Mus musculus)
phospho-Frs2 [cytosol]
(Rattus norvegicus)
phospho-p-6Y-FRS2 [cytosol]
(Sus scrofa)
phospho-FRS2 [cytosol]
(Bos taurus)
phospho-FRS2 [cytosol]
(Canis familiaris)
phospho-FRS2 [cytosol]
(Gallus gallus)
phospho-frs2 [cytosol]
(Xenopus tropicalis)
Modified Residues
Name
O4'-phospho-L-tyrosine at 436
Coordinate
436
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 196
Coordinate
196
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 306
Coordinate
306
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 349
Coordinate
349
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 392
Coordinate
392
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 471
Coordinate
471
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
XP_016874206.1
,
NP_006645.3
,
NP_001265282.1
,
XP_016874208.1
,
NP_001265284.1
,
XP_016874207.1
,
NP_001265286.1
,
NP_001265280.1
,
NP_001265283.1
,
NP_001265285.1
,
NP_001036020.1
OpenTargets
ENSG00000166225
GeneCards
Q8WU20
HPA
ENSG00000166225-FRS2
Ensembl
ENSP00000447241
,
ENST00000549921
,
ENSP00000381083
,
ENST00000550389
,
ENSP00000450048
,
ENST00000397997
,
ENSG00000166225
PRO
Q8WU20
Pharos - Targets
Q8WU20
PDB
2MFQ
,
1XR0
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q06124 PTPN11
4
p-Y542-PTPN11 [cytosol]
(R-HSA-1369081)
PTPN11 [nucleoplasm]
(R-HSA-8937745)
PTPN11 [cytosol]
(R-HSA-162563)
p-Y542,Y580-PTPN11 [cytosol]
(R-HSA-162573)
0.649
4
UniProt:P11362 FGFR1
9
FGFR1(22-763):TACC1(571-805) fusion [plasma membrane]
(R-HSA-8853241)
FGFR1 K656E [plasma membrane]
(R-HSA-1614373)
FGFR1 N546K [plasma membrane]
(R-HSA-1614377)
FGFR1 R576W [plasma membrane]
(R-HSA-2011844)
p-6Y-FGFR1(22-763):TACC1(571-805) fusion [plasma membrane]
(R-HSA-8853142)
p-8Y-FGFR1 K656E [plasma membrane]
(R-HSA-2023356)
p-8Y-FGFR1 N546K [plasma membrane]
(R-HSA-2023358)
p-8Y- FGFR1 R576W [plasma membrane]
(R-HSA-2023361)
FGFR1 [plasma membrane]
(R-HSA-9756433)
0.569
3
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