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SIRPA [plasma membrane]
Stable Identifier
R-HSA-3209922
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Tyrosine-protein phosphatase non-receptor type substrate 1, SHPS1_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Homo sapiens)
Signal regulatory protein family interactions (Homo sapiens)
Phosphorylation of ITIM motif in SIRP alpha (Homo sapiens)
SIRPA:CD47 [plasma membrane] (Homo sapiens)
SIRPA [plasma membrane] (Homo sapiens)
SIRP alpha binds CD47 (Homo sapiens)
SIRPA [plasma membrane] (Homo sapiens)
SIRPA:CD47 [plasma membrane] (Homo sapiens)
SIRPA [plasma membrane] (Homo sapiens)
SIRPA binds SFTPA oligomer, SFTPD oligomer (Homo sapiens)
SIRPA [plasma membrane] (Homo sapiens)
SIRPA:SFTPA oligomer, SFTPD oligomer [plasma membrane] (Homo sapiens)
SIRPA [plasma membrane] (Homo sapiens)
Hemostasis (Homo sapiens)
Cell surface interactions at the vascular wall (Homo sapiens)
CD47 binds SIRP (Homo sapiens)
CD47-binding SIRPs [plasma membrane] (Homo sapiens)
SIRPA [plasma membrane] (Homo sapiens)
CD47-binding SIRPs:CD47 [plasma membrane] (Homo sapiens)
CD47-binding SIRPs [plasma membrane] (Homo sapiens)
SIRPA [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of ficolin-rich granule membrane proteins (Homo sapiens)
Ficolin-rich granule membrane proteins [plasma membrane] (Homo sapiens)
SIRPA [plasma membrane] (Homo sapiens)
Exocytosis of tertiary granule membrane proteins (Homo sapiens)
Tertiary granule membrane proteins [plasma membrane] (Homo sapiens)
SIRPA [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P78324 SIRPA
Gene Names
SIRPA, BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP
Chain
signal peptide:1-30, chain:31-504
Reference Genes
BioGPS Gene:140885 SIRPA
COSMIC (genes):SIRPA SIRPA
CTD Gene:140885 SIRPA
dbSNP Gene:140885 SIRPA
ENSEMBL:ENSG00000198053 SIRPA
ENSEMBL_homo_sapiens_GENE:ENSG00000198053.12 SIRPA
HGNC:9662 SIRPA
KEGG Gene (Homo sapiens):140885 SIRPA
Monarch:140885 SIRPA
NCBI Gene:140885 SIRPA
OMIM:602461 SIRPA
UCSC:P78324 SIRPA
Reference Transcript
RefSeq:NM_001040022.1 SIRPA
RefSeq:NM_080792.2 SIRPA
RefSeq:XM_005260670.3 SIRPA
RefSeq:NM_001040023.1 SIRPA
RefSeq:NM_001330728.1 SIRPA
Other Identifiers
11719727_a_at
11719728_s_at
11749535_a_at
140885
16910728
202895_PM_s_at
202895_s_at
202896_PM_s_at
202896_s_at
202897_PM_at
202897_at
3873636
3873637
3873639
3873654
3873655
3873656
3873657
3873659
3873662
3873664
3873667
3873669
3873670
3873671
3873672
3873673
3873674
3894706
3894736
3894738
3894740
3894750
3894752
3894755
3894777
3942454
3942456
3942457
3942458
3942459
40144_at
8060418
91827_at
A_14_P133542
A_23_P210708
A_24_P259083
A_24_P267619
A_33_P3343872
D86043_s_at
GE53660
GE81424
GO:0001933
GO:0002376
GO:0005576
GO:0005615
GO:0005886
GO:0006954
GO:0007155
GO:0009986
GO:0010468
GO:0016020
GO:0016192
GO:0016477
GO:0017124
GO:0019903
GO:0023052
GO:0030695
GO:0031410
GO:0032649
GO:0032651
GO:0032675
GO:0032680
GO:0032688
GO:0032715
GO:0032720
GO:0034113
GO:0035696
GO:0036211
GO:0043226
GO:0045019
GO:0045428
GO:0046329
GO:0048870
GO:0050728
GO:0050765
GO:0050766
GO:0050870
GO:0051716
GO:0070062
GO:0070301
GO:0070373
GO:0070821
GO:0071222
GO:0071346
GO:0071347
GO:0071349
GO:0071641
GO:0071650
GO:0086080
GO:0098542
GO:0098609
GO:0098631
GO:0098632
GO:0098772
GO:0101003
GO:1900016
GO:1903720
GO:1990405
GO:1990782
HMNXSV003049543
Hs.287353.0.S1_3p_s_at
ILMN_1758146
ILMN_2372974
PH_hs_0009416
TC20000019.hg
U06681_at
Y10375_s_at
g1864010_3p_a_at
g4758977_3p_x_at
g6518912_3p_at
Participates
as a component of
SIRPA:SFTPA oligomer, SFTPD oligomer [plasma membrane] (Homo sapiens)
SIRPA:CD47 [plasma membrane] (Homo sapiens)
as an input of
SIRPA binds SFTPA oligomer, SFTPD oligomer (Homo sapiens)
SIRP alpha binds CD47 (Homo sapiens)
as a member of
CD47-binding SIRPs [plasma membrane] (Homo sapiens)
Ficolin-rich granule membrane proteins [plasma membrane] (Homo sapiens)
Tertiary granule membrane proteins [plasma membrane] (Homo sapiens)
Other forms of this molecule
p-Y429,Y453,Y470,Y496-SIRPA [plasma membrane]
SIRPA [ficolin-1-rich granule membrane]
SIRPA [tertiary granule membrane]
Inferred To
Homologues of SIRPA [plasma membrane]
(Bos taurus)
Homologues of SIRPA [plasma membrane]
(Canis familiaris)
Homologues of SIRPA [plasma membrane]
(Gallus gallus)
Homologues of SIRPA [plasma membrane]
(Sus scrofa)
Sirpa [plasma membrane]
(Mus musculus)
Sirpa [plasma membrane]
(Rattus norvegicus)
LOC100739707 [plasma membrane]
(Sus scrofa)
SIRPB1 [plasma membrane]
(Bos taurus)
LOC100736623 [plasma membrane]
(Sus scrofa)
LOC102161654 [plasma membrane]
(Sus scrofa)
SIRPA [plasma membrane]
(Bos taurus)
SIRPA [plasma membrane]
(Canis familiaris)
SIRPA [plasma membrane]
(Gallus gallus)
SIRPA [plasma membrane]
(Sus scrofa)
LOC119868972 [plasma membrane]
(Canis familiaris)
Cross References
RefSeq
NP_001317657.1
,
XP_005260727.1
,
NP_001035112.1
,
NP_001035111.1
,
NP_542970.1
Guide to Pharmacology - Targets
2942
OpenTargets
ENSG00000198053
HPA
ENSG00000198053-SIRPA
GeneCards
P78324
Ensembl
ENSP00000348307
,
ENST00000356025
,
ENSP00000478763
,
ENST00000622179
,
ENSP00000382941
,
ENSG00000198053
,
ENSP00000351621
,
ENST00000400068
,
ENST00000358771
PRO
P78324
Pharos - Targets
P78324
PDB
4CMM
,
7KPG
,
2JJT
,
7ST5
,
6NMS
,
6NMR
,
2JJS
,
6NMV
,
6BIT
,
2WNG
,
6NMU
,
2UV3
,
6NMT
,
7YGG
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q08722 CD47
3
CD47 [specific granule membrane]
(R-HSA-6799523)
CD47 [tertiary granule membrane]
(R-HSA-6801033)
CD47 [plasma membrane]
(R-HSA-197736)
0.59
2
UniProt:Q06124 PTPN11
4
p-Y542-PTPN11 [cytosol]
(R-HSA-1369081)
PTPN11 [nucleoplasm]
(R-HSA-8937745)
PTPN11 [cytosol]
(R-HSA-162563)
p-Y542,Y580-PTPN11 [cytosol]
(R-HSA-162573)
0.527
3
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