Reactome | Ub [cytosol]

Schema > DefinedSet > Entries

Ub [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-RNO-9033504] Ub:PEX5L [cytosol] - Rattus norvegicus [Complex:R-RNO-6782795] USP5:Ub [cytosol] - Rattus norvegicus [Complex:R-RNO-206877] NFKB1:RELA:p-S32,S36-NFKBIA:Ub [cytosol] - Rattus norvegicus
consumedByEvent	[BlackBoxEvent:R-RNO-450580] AUF1 (hnRNP D0) is ubiquitinylated - Rattus norvegicus [BlackBoxEvent:R-RNO-450580] AUF1 (hnRNP D0) is ubiquitinylated - Rattus norvegicus [BlackBoxEvent:R-RNO-450580] AUF1 (hnRNP D0) is ubiquitinylated - Rattus norvegicus [BlackBoxEvent:R-RNO-450580] AUF1 (hnRNP D0) is ubiquitinylated - Rattus norvegicus [Reaction:R-RNO-8852132] Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol - Rattus norvegicus [Reaction:R-RNO-9766645] CUL3:RBX1 ubiquitinates KEAP1 - Rattus norvegicus [Reaction:R-RNO-9766645] CUL3:RBX1 ubiquitinates KEAP1 - Rattus norvegicus [Reaction:R-RNO-9766645] CUL3:RBX1 ubiquitinates KEAP1 - Rattus norvegicus [BlackBoxEvent:R-RNO-9861640] CTLH E3 ligase ubiquitinates PKM-1 - Rattus norvegicus [Reaction:R-RNO-5654684] CBL ubiquitinates FRS2 and FGFR4 - Rattus norvegicus [BlackBoxEvent:R-RNO-9958873] Cell-to-cell contact through homophilic cadherin interactions inhibits RAC1/CDC42 ubiquitination - Rattus norvegicus [BlackBoxEvent:R-RNO-9958873] Cell-to-cell contact through homophilic cadherin interactions inhibits RAC1/CDC42 ubiquitination - Rattus norvegicus [BlackBoxEvent:R-RNO-9958873] Cell-to-cell contact through homophilic cadherin interactions inhibits RAC1/CDC42 ubiquitination - Rattus norvegicus [Reaction:R-RNO-5654679] CBL ubiquitinates FRS2 and FGFR3 - Rattus norvegicus [Reaction:R-RNO-8948709] DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 - Rattus norvegicus [Reaction:R-RNO-8948709] DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 - Rattus norvegicus [Reaction:R-RNO-8948709] DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 - Rattus norvegicus [Reaction:R-RNO-5654677] CBL ubiquitinates FRS2 and FGFR2 - Rattus norvegicus [Reaction:R-RNO-9934753] CBLL1 ubiquitinates CDH1 - Rattus norvegicus [Reaction:R-RNO-9934753] CBLL1 ubiquitinates CDH1 - Rattus norvegicus [Reaction:R-RNO-9934753] CBLL1 ubiquitinates CDH1 - Rattus norvegicus [Reaction:R-RNO-9934753] CBLL1 ubiquitinates CDH1 - Rattus norvegicus [Reaction:R-RNO-9934753] CBLL1 ubiquitinates CDH1 - Rattus norvegicus [Reaction:R-RNO-9934753] CBLL1 ubiquitinates CDH1 - Rattus norvegicus [Reaction:R-RNO-2130286] Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) - Rattus norvegicus [Reaction:R-RNO-2130286] Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) - Rattus norvegicus [Reaction:R-RNO-2130286] Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) - Rattus norvegicus [Reaction:R-RNO-2130286] Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) - Rattus norvegicus [Reaction:R-RNO-3640861] RNF146 ubiquitinates ADP-ribosylated AXIN - Rattus norvegicus [Reaction:R-RNO-1358790] RNF41 ubiquitinates ERBB3 - Rattus norvegicus [BlackBoxEvent:R-RNO-9688831] STUB1 ubiquitinates RIPK3 at K55, K363 - Rattus norvegicus [Polymerisation:R-RNO-450358] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation - Rattus norvegicus [BlackBoxEvent:R-RNO-975147] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane - Rattus norvegicus [BlackBoxEvent:R-RNO-975147] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane - Rattus norvegicus [BlackBoxEvent:R-RNO-975147] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane - Rattus norvegicus [BlackBoxEvent:R-RNO-975147] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane - Rattus norvegicus [BlackBoxEvent:R-RNO-975147] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane - Rattus norvegicus [BlackBoxEvent:R-RNO-975147] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane - Rattus norvegicus [BlackBoxEvent:R-RNO-975147] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane - Rattus norvegicus [BlackBoxEvent:R-RNO-975147] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane - Rattus norvegicus [BlackBoxEvent:R-RNO-975147] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane - Rattus norvegicus [BlackBoxEvent:R-RNO-9823939] IKK? (IKBKE) is ubiquitinated within the activated TLR4 - Rattus norvegicus [BlackBoxEvent:R-RNO-9823904] TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 - Rattus norvegicus [Reaction:R-RNO-983153] E1 mediated ubiquitin activation - Rattus norvegicus [Reaction:R-RNO-2160935] SMURF1 ubiquitinates RHOA - Rattus norvegicus [Polymerisation:R-RNO-936986] Activated TRAF6 synthesizes unanchored polyubiquitin chains - Rattus norvegicus [BlackBoxEvent:R-RNO-9645414] Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer - Rattus norvegicus [BlackBoxEvent:R-RNO-9645414] Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer - Rattus norvegicus [BlackBoxEvent:R-RNO-9645414] Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer - Rattus norvegicus [BlackBoxEvent:R-RNO-9645414] Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer - Rattus norvegicus [BlackBoxEvent:R-RNO-9645414] Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer - Rattus norvegicus [BlackBoxEvent:R-RNO-9645414] Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer - Rattus norvegicus [BlackBoxEvent:R-RNO-9645414] Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer - Rattus norvegicus [BlackBoxEvent:R-RNO-9645414] Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer - Rattus norvegicus [BlackBoxEvent:R-RNO-9645414] Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer - Rattus norvegicus [Polymerisation:R-RNO-9645394] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation - Rattus norvegicus [BlackBoxEvent:R-RNO-9750946] TRAF2,6 ubiquitinates NLRC5 - Rattus norvegicus [BlackBoxEvent:R-RNO-9750946] TRAF2,6 ubiquitinates NLRC5 - Rattus norvegicus [BlackBoxEvent:R-RNO-9750946] TRAF2,6 ubiquitinates NLRC5 - Rattus norvegicus [Reaction:R-RNO-174159] Ubiquitination of Emi1 by SCF-beta-TrCP - Rattus norvegicus [Reaction:R-RNO-174159] Ubiquitination of Emi1 by SCF-beta-TrCP - Rattus norvegicus [Reaction:R-RNO-174159] Ubiquitination of Emi1 by SCF-beta-TrCP - Rattus norvegicus [Reaction:R-RNO-174144] Ubiquitination of Securin by phospho-APC/C:Cdc20 complex - Rattus norvegicus [Reaction:R-RNO-174144] Ubiquitination of Securin by phospho-APC/C:Cdc20 complex - Rattus norvegicus [Reaction:R-RNO-174144] Ubiquitination of Securin by phospho-APC/C:Cdc20 complex - Rattus norvegicus [Reaction:R-RNO-264444] Autoubiquitination of phospho-COP1(Ser-387 ) - Rattus norvegicus [Reaction:R-RNO-264444] Autoubiquitination of phospho-COP1(Ser-387 ) - Rattus norvegicus [Reaction:R-RNO-264444] Autoubiquitination of phospho-COP1(Ser-387 ) - Rattus norvegicus [Reaction:R-RNO-264444] Autoubiquitination of phospho-COP1(Ser-387 ) - Rattus norvegicus [Reaction:R-RNO-173542] SMURF2 ubiquitinates SMAD2 - Rattus norvegicus [Reaction:R-RNO-8956026] CUL9:RBX1 ubiquitinates BIRC5 - Rattus norvegicus [Reaction:R-RNO-8956026] CUL9:RBX1 ubiquitinates BIRC5 - Rattus norvegicus [Reaction:R-RNO-8956026] CUL9:RBX1 ubiquitinates BIRC5 - Rattus norvegicus [Reaction:R-RNO-5362412] SYVN1 ubiquitinates Hh C-terminal fragments - Rattus norvegicus [Reaction:R-RNO-9759154] TRIM21 ubiquitinates SQSTM1 - Rattus norvegicus [Reaction:R-RNO-9759154] TRIM21 ubiquitinates SQSTM1 - Rattus norvegicus [Reaction:R-RNO-9759154] TRIM21 ubiquitinates SQSTM1 - Rattus norvegicus [Reaction:R-RNO-9755304] MUL1 ubiquitinates UBXN7 - Rattus norvegicus [Reaction:R-RNO-9755304] MUL1 ubiquitinates UBXN7 - Rattus norvegicus [Reaction:R-RNO-9755304] MUL1 ubiquitinates UBXN7 - Rattus norvegicus [Reaction:R-RNO-8866546] RNF5 and RNF185 ubiquitinate misfolded CFTR - Rattus norvegicus [Reaction:R-RNO-9759172] KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer - Rattus norvegicus [Reaction:R-RNO-9759172] KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer - Rattus norvegicus [Reaction:R-RNO-9759172] KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer - Rattus norvegicus [Reaction:R-RNO-9755505] KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 - Rattus norvegicus [Reaction:R-RNO-9755505] KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 - Rattus norvegicus [Reaction:R-RNO-9755505] KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 - Rattus norvegicus [Reaction:R-RNO-8875183] CBL monoubiquitinates activated MET - Rattus norvegicus [Reaction:R-RNO-8956684] ITCH polyubiquitinates TP73 - Rattus norvegicus [Reaction:R-RNO-8956684] ITCH polyubiquitinates TP73 - Rattus norvegicus [Reaction:R-RNO-8956684] ITCH polyubiquitinates TP73 - Rattus norvegicus [Reaction:R-RNO-8956684] ITCH polyubiquitinates TP73 - Rattus norvegicus [Reaction:R-RNO-8956684] ITCH polyubiquitinates TP73 - Rattus norvegicus [Reaction:R-RNO-8956684] ITCH polyubiquitinates TP73 - Rattus norvegicus [Reaction:R-RNO-8956684] ITCH polyubiquitinates TP73 - Rattus norvegicus [Reaction:R-RNO-8956684] ITCH polyubiquitinates TP73 - Rattus norvegicus [Reaction:R-RNO-8956684] ITCH polyubiquitinates TP73 - Rattus norvegicus [Reaction:R-RNO-8956684] ITCH polyubiquitinates TP73 - Rattus norvegicus [Reaction:R-RNO-8956684] ITCH polyubiquitinates TP73 - Rattus norvegicus [Reaction:R-RNO-8956684] ITCH polyubiquitinates TP73 - Rattus norvegicus [Reaction:R-RNO-5610742] SCF(beta-TrCP) ubiquitinates p-GLI1 - Rattus norvegicus [Reaction:R-RNO-5635864] NUMB:ITCH ubiquitinates GLI1 - Rattus norvegicus [Reaction:R-RNO-5691108] SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 - Rattus norvegicus [Reaction:R-RNO-5691108] SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 - Rattus norvegicus [Reaction:R-RNO-5691108] SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 - Rattus norvegicus [Reaction:R-RNO-9929490] CD274 ubiquitination by SPOP:CUL3:RBX1 complex - Rattus norvegicus [Reaction:R-RNO-9929490] CD274 ubiquitination by SPOP:CUL3:RBX1 complex - Rattus norvegicus [Reaction:R-RNO-9929490] CD274 ubiquitination by SPOP:CUL3:RBX1 complex - Rattus norvegicus [Reaction:R-RNO-9929350] Ubiquitination of CD274 by BTRC-SCF E3-ligase complex - Rattus norvegicus [Reaction:R-RNO-9929350] Ubiquitination of CD274 by BTRC-SCF E3-ligase complex - Rattus norvegicus [Reaction:R-RNO-9929350] Ubiquitination of CD274 by BTRC-SCF E3-ligase complex - Rattus norvegicus [BlackBoxEvent:R-RNO-9861563] CTLH E3 ligase ubiquitinates LDHA - Rattus norvegicus [Reaction:R-RNO-8854041] SCF-FBXL7 ubiquitinates AURKA - Rattus norvegicus [Reaction:R-RNO-8854041] SCF-FBXL7 ubiquitinates AURKA - Rattus norvegicus [Reaction:R-RNO-8854041] SCF-FBXL7 ubiquitinates AURKA - Rattus norvegicus [Reaction:R-RNO-8854051] SCF-FBXL18 ubiquitinates FBXL7 - Rattus norvegicus [Reaction:R-RNO-8854051] SCF-FBXL18 ubiquitinates FBXL7 - Rattus norvegicus [Reaction:R-RNO-8854051] SCF-FBXL18 ubiquitinates FBXL7 - Rattus norvegicus [Reaction:R-RNO-3000335] SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA - Rattus norvegicus [BlackBoxEvent:R-RNO-1168643] SCF-beta-TrCP ubiquitinylates IkB - Rattus norvegicus [Reaction:R-RNO-5654672] CBL ubiquitinates FRS2 and FGFR1 - Rattus norvegicus [Reaction:R-RNO-209536] IkB is ubiquitinated and degraded - Rattus norvegicus [BlackBoxEvent:R-RNO-209566] TRAF6 is auto-ubiquitinated - Rattus norvegicus [Reaction:R-RNO-69015] Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex - Rattus norvegicus [Reaction:R-RNO-3134804] STING ubiquitination by TRIM32 or TRIM56 - Rattus norvegicus [Reaction:R-RNO-3134804] STING ubiquitination by TRIM32 or TRIM56 - Rattus norvegicus [Reaction:R-RNO-3134804] STING ubiquitination by TRIM32 or TRIM56 - Rattus norvegicus [Reaction:R-RNO-209063] Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex - Rattus norvegicus [Reaction:R-RNO-9021523] WWP2 ubiquitinates NOTCH3 - Rattus norvegicus [Reaction:R-RNO-1912357] ITCH ubiquitinates DTX - Rattus norvegicus [Reaction:R-RNO-5610746] SCF(beta-TrCP) ubiquitinates p-GLI3 - Rattus norvegicus [Reaction:R-RNO-1977296] NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer - Rattus norvegicus [Reaction:R-RNO-1253282] ERBB4 ubiquitination by WWP1/ITCH - Rattus norvegicus [Reaction:R-RNO-934604] Phosphorylated SPRY2 is ubiquitinated by CBL - Rattus norvegicus [BlackBoxEvent:R-RNO-9766227] MDM2 mediates CDH1 ubiquitination - Rattus norvegicus [BlackBoxEvent:R-RNO-9766227] MDM2 mediates CDH1 ubiquitination - Rattus norvegicus [BlackBoxEvent:R-RNO-9766227] MDM2 mediates CDH1 ubiquitination - Rattus norvegicus [Reaction:R-RNO-4641246] ZNRF3 autoubiquitinates to promote its internalization - Rattus norvegicus [Reaction:R-RNO-4641129] AXIN is ubiquitinated by SMURF2 - Rattus norvegicus [Reaction:R-RNO-1504190] DVL is ubiquitinated by CUL3:KLHL12:RBX1 - Rattus norvegicus [Reaction:R-RNO-4641159] DVL1 is ubiquitinated by HECW1 - Rattus norvegicus [Reaction:R-RNO-4641253] ZNRF3 ubiquitinates FZD to promote its downregulation - Rattus norvegicus [Reaction:R-RNO-4608852] SMURF1/2 ubiquitinates PRICKLE1 - Rattus norvegicus [Reaction:R-RNO-1918095] CUL5 mediates ubiquitination of ERBB2 - Rattus norvegicus [Reaction:R-RNO-1358792] RNF41 ubiquitinates activated ERBB3 - Rattus norvegicus [Reaction:R-RNO-1358789] Self-ubiquitination of RNF41 - Rattus norvegicus [Reaction:R-RNO-1918092] CHIP (STUB1) mediates ubiquitination of ERBB2 - Rattus norvegicus [Reaction:R-RNO-1918092] CHIP (STUB1) mediates ubiquitination of ERBB2 - Rattus norvegicus [Reaction:R-RNO-5674022] BRAP autoubiquitinates - Rattus norvegicus [Reaction:R-RNO-5658424] KBTBD7:CUL3:RBX1 ubiquitinates NF1 - Rattus norvegicus [Reaction:R-RNO-183051] CBL ubiquitinates Sprouty - Rattus norvegicus [Reaction:R-RNO-183036] Ubiquitination of stimulated EGFR (CBL:GRB2) - Rattus norvegicus [Reaction:R-RNO-183036] Ubiquitination of stimulated EGFR (CBL:GRB2) - Rattus norvegicus [Reaction:R-RNO-183084] CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix - Rattus norvegicus [Reaction:R-RNO-183084] CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix - Rattus norvegicus [Reaction:R-RNO-182986] CBL-mediated ubiquitination of CIN85 - Rattus norvegicus [Reaction:R-RNO-182993] Ubiquitination of stimulated EGFR (CBL) - Rattus norvegicus [Reaction:R-RNO-182993] Ubiquitination of stimulated EGFR (CBL) - Rattus norvegicus [Reaction:R-RNO-8848829] CBL autoubiquitinates - Rattus norvegicus [Reaction:R-RNO-8848829] CBL autoubiquitinates - Rattus norvegicus [Reaction:R-RNO-8848829] CBL autoubiquitinates - Rattus norvegicus [Reaction:R-RNO-8948775] MKRN1 polyubiquitinates PTEN - Rattus norvegicus [Reaction:R-RNO-8948775] MKRN1 polyubiquitinates PTEN - Rattus norvegicus [Reaction:R-RNO-8948775] MKRN1 polyubiquitinates PTEN - Rattus norvegicus [Reaction:R-RNO-8948832] RNF146 polyubiquitinates PARylated PTEN - Rattus norvegicus [Reaction:R-RNO-8948832] RNF146 polyubiquitinates PARylated PTEN - Rattus norvegicus [Reaction:R-RNO-8948832] RNF146 polyubiquitinates PARylated PTEN - Rattus norvegicus [Reaction:R-RNO-8948832] RNF146 polyubiquitinates PARylated PTEN - Rattus norvegicus [Reaction:R-RNO-8948832] RNF146 polyubiquitinates PARylated PTEN - Rattus norvegicus [Reaction:R-RNO-8948832] RNF146 polyubiquitinates PARylated PTEN - Rattus norvegicus [Reaction:R-RNO-8948832] RNF146 polyubiquitinates PARylated PTEN - Rattus norvegicus [Reaction:R-RNO-8948832] RNF146 polyubiquitinates PARylated PTEN - Rattus norvegicus [Reaction:R-RNO-8948832] RNF146 polyubiquitinates PARylated PTEN - Rattus norvegicus [Reaction:R-RNO-8851011] TRIM27 polyubiquitinates PTEN - Rattus norvegicus [Reaction:R-RNO-8851011] TRIM27 polyubiquitinates PTEN - Rattus norvegicus [Reaction:R-RNO-8851011] TRIM27 polyubiquitinates PTEN - Rattus norvegicus [Reaction:R-RNO-6807134] NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN - Rattus norvegicus [Reaction:R-RNO-6807134] NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN - Rattus norvegicus [Reaction:R-RNO-6807134] NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN - Rattus norvegicus [Reaction:R-RNO-6807106] PTEN undergoes monoubiquitination - Rattus norvegicus [BlackBoxEvent:R-RNO-2213017] Auto-ubiquitination of TRAF3 - Rattus norvegicus [BlackBoxEvent:R-RNO-5362500] TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 - Rattus norvegicus [Reaction:R-RNO-9664888] ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 - Rattus norvegicus [BlackBoxEvent:R-RNO-936942] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 - Rattus norvegicus [BlackBoxEvent:R-RNO-936942] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 - Rattus norvegicus [BlackBoxEvent:R-RNO-936942] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 - Rattus norvegicus [BlackBoxEvent:R-RNO-936942] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 - Rattus norvegicus [BlackBoxEvent:R-RNO-936942] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 - Rattus norvegicus [BlackBoxEvent:R-RNO-936942] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 - Rattus norvegicus [BlackBoxEvent:R-RNO-936942] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 - Rattus norvegicus [BlackBoxEvent:R-RNO-936942] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 - Rattus norvegicus [BlackBoxEvent:R-RNO-936942] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 - Rattus norvegicus [BlackBoxEvent:R-RNO-936952] Auto ubiquitination of TRAF6 bound to the activated TLR4 complex - Rattus norvegicus [BlackBoxEvent:R-RNO-936952] Auto ubiquitination of TRAF6 bound to the activated TLR4 complex - Rattus norvegicus [BlackBoxEvent:R-RNO-936952] Auto ubiquitination of TRAF6 bound to the activated TLR4 complex - Rattus norvegicus [Reaction:R-RNO-5684250] SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 - Rattus norvegicus [Reaction:R-RNO-5684250] SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 - Rattus norvegicus [Reaction:R-RNO-5684250] SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 - Rattus norvegicus [Reaction:R-RNO-5684250] SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 - Rattus norvegicus [Reaction:R-RNO-5684250] SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 - Rattus norvegicus [Reaction:R-RNO-5684250] SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 - Rattus norvegicus [Reaction:R-RNO-5684250] SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 - Rattus norvegicus [Reaction:R-RNO-5684250] SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 - Rattus norvegicus [Reaction:R-RNO-5684250] SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 - Rattus norvegicus [Reaction:R-RNO-179417] Multiubiquitination of Nek2A - Rattus norvegicus [Reaction:R-RNO-179417] Multiubiquitination of Nek2A - Rattus norvegicus [Reaction:R-RNO-179417] Multiubiquitination of Nek2A - Rattus norvegicus [Reaction:R-RNO-174227] Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex - Rattus norvegicus [Reaction:R-RNO-174227] Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex - Rattus norvegicus [Reaction:R-RNO-174227] Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex - Rattus norvegicus [Reaction:R-RNO-174227] Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex - Rattus norvegicus [Reaction:R-RNO-174195] Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex - Rattus norvegicus [Reaction:R-RNO-174195] Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex - Rattus norvegicus [Reaction:R-RNO-174195] Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex - Rattus norvegicus [Reaction:R-RNO-174195] Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex - Rattus norvegicus [Reaction:R-RNO-174104] Ubiquitination of Cyclin A by APC/C:Cdc20 complex - Rattus norvegicus [Reaction:R-RNO-174104] Ubiquitination of Cyclin A by APC/C:Cdc20 complex - Rattus norvegicus [Reaction:R-RNO-174104] Ubiquitination of Cyclin A by APC/C:Cdc20 complex - Rattus norvegicus [Reaction:R-RNO-174104] Ubiquitination of Cyclin A by APC/C:Cdc20 complex - Rattus norvegicus [Reaction:R-RNO-2187368] STUB1 (CHIP) ubiquitinates SMAD3 - Rattus norvegicus [Reaction:R-RNO-8852134] UBA1 adenylates ubiquitin in the cytosol - Rattus norvegicus [Reaction:R-RNO-2682349] RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels - Rattus norvegicus [Reaction:R-RNO-2682349] RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels - Rattus norvegicus [Reaction:R-RNO-2682349] RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels - Rattus norvegicus [Reaction:R-RNO-2682349] RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels - Rattus norvegicus [Reaction:R-RNO-2682349] RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels - Rattus norvegicus [Reaction:R-RNO-2682349] RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels - Rattus norvegicus [Reaction:R-RNO-3134946] DDX41 ubiquitination by TRIM21 - Rattus norvegicus [Reaction:R-RNO-3134946] DDX41 ubiquitination by TRIM21 - Rattus norvegicus [Reaction:R-RNO-3134946] DDX41 ubiquitination by TRIM21 - Rattus norvegicus [Reaction:R-RNO-183089] CBL binds and ubiquitinates phosphorylated Sprouty - Rattus norvegicus [BlackBoxEvent:R-RNO-9758604] Ubiquitination of IKBKG by TRAF6 - Rattus norvegicus [BlackBoxEvent:R-RNO-9758604] Ubiquitination of IKBKG by TRAF6 - Rattus norvegicus [BlackBoxEvent:R-RNO-9758604] Ubiquitination of IKBKG by TRAF6 - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10103388
displayName	Ub [cytosol]
hasMember	[EntityWithAccessionedSequence:R-RNO-939205] Uba52 [cytosol] - Rattus norvegicus [EntityWithAccessionedSequence:R-RNO-939203] Ubc [cytosol] - Rattus norvegicus [EntityWithAccessionedSequence:R-RNO-939214] Ubb [cytosol] - Rattus norvegicus [EntityWithAccessionedSequence:R-RNO-939188] Rps27a [cytosol] - Rattus norvegicus
inDisease	false
inferredFrom	[DefinedSet:R-HSA-113595] Ub [cytosol] - Homo sapiens
maxDepth	2
name	Ub ubiquitin
producedByEvent	[BlackBoxEvent:R-RNO-5687112] MAPK6 is degraded by the 26S proteasome - Rattus norvegicus [BlackBoxEvent:R-RNO-450466] AUF1:mRNA complex is degraded - Rattus norvegicus [BlackBoxEvent:R-RNO-450466] AUF1:mRNA complex is degraded - Rattus norvegicus [BlackBoxEvent:R-RNO-450466] AUF1:mRNA complex is degraded - Rattus norvegicus [BlackBoxEvent:R-RNO-450466] AUF1:mRNA complex is degraded - Rattus norvegicus [BlackBoxEvent:R-RNO-450466] AUF1:mRNA complex is degraded - Rattus norvegicus [BlackBoxEvent:R-RNO-450466] AUF1:mRNA complex is degraded - Rattus norvegicus [BlackBoxEvent:R-RNO-450466] AUF1:mRNA complex is degraded - Rattus norvegicus [BlackBoxEvent:R-RNO-450466] AUF1:mRNA complex is degraded - Rattus norvegicus [BlackBoxEvent:R-RNO-450466] AUF1:mRNA complex is degraded - Rattus norvegicus [BlackBoxEvent:R-RNO-450466] AUF1:mRNA complex is degraded - Rattus norvegicus [BlackBoxEvent:R-RNO-450466] AUF1:mRNA complex is degraded - Rattus norvegicus [BlackBoxEvent:R-RNO-450466] AUF1:mRNA complex is degraded - Rattus norvegicus [BlackBoxEvent:R-RNO-9954728] The proteasome degrades the K48-polyubiquitinated alanine-tailed nascent peptide - Rattus norvegicus [BlackBoxEvent:R-RNO-9954728] The proteasome degrades the K48-polyubiquitinated alanine-tailed nascent peptide - Rattus norvegicus [BlackBoxEvent:R-RNO-9954728] The proteasome degrades the K48-polyubiquitinated alanine-tailed nascent peptide - Rattus norvegicus [Reaction:R-RNO-8865182] OTUD7A hydrolyses K11diUb - Rattus norvegicus [Reaction:R-RNO-8865182] OTUD7A hydrolyses K11diUb - Rattus norvegicus [BlackBoxEvent:R-RNO-5362448] Hh C-terminal fragments are degraded by the proteasome - Rattus norvegicus [BlackBoxEvent:R-RNO-9934893] Proteolysis of K48polyUb-K,p-S-PER1,2,3 - Rattus norvegicus [BlackBoxEvent:R-RNO-9934893] Proteolysis of K48polyUb-K,p-S-PER1,2,3 - Rattus norvegicus [BlackBoxEvent:R-RNO-9934893] Proteolysis of K48polyUb-K,p-S-PER1,2,3 - Rattus norvegicus [BlackBoxEvent:R-RNO-9755306] ub UBXN7 is degraded by the 26S proteasome - Rattus norvegicus [BlackBoxEvent:R-RNO-8866553] misfolded CFTR is degraded by the 26S proteasome - Rattus norvegicus [BlackBoxEvent:R-RNO-8932355] 26S proteasome degrades Ub-NFE2L2 - Rattus norvegicus [BlackBoxEvent:R-RNO-8952408] Polyubiquitinated RUNX3 is degraded by the proteasome - Rattus norvegicus [BlackBoxEvent:R-RNO-8952408] Polyubiquitinated RUNX3 is degraded by the proteasome - Rattus norvegicus [BlackBoxEvent:R-RNO-8952408] Polyubiquitinated RUNX3 is degraded by the proteasome - Rattus norvegicus [BlackBoxEvent:R-RNO-8952408] Polyubiquitinated RUNX3 is degraded by the proteasome - Rattus norvegicus [BlackBoxEvent:R-RNO-8952408] Polyubiquitinated RUNX3 is degraded by the proteasome - Rattus norvegicus [BlackBoxEvent:R-RNO-8952408] Polyubiquitinated RUNX3 is degraded by the proteasome - Rattus norvegicus [BlackBoxEvent:R-RNO-8957265] 26S proteasome degrades TP73 polyubiquitinated by ITCH - Rattus norvegicus [BlackBoxEvent:R-RNO-8957265] 26S proteasome degrades TP73 polyubiquitinated by ITCH - Rattus norvegicus [BlackBoxEvent:R-RNO-8957265] 26S proteasome degrades TP73 polyubiquitinated by ITCH - Rattus norvegicus [BlackBoxEvent:R-RNO-8957265] 26S proteasome degrades TP73 polyubiquitinated by ITCH - Rattus norvegicus [BlackBoxEvent:R-RNO-8957265] 26S proteasome degrades TP73 polyubiquitinated by ITCH - Rattus norvegicus [BlackBoxEvent:R-RNO-8957265] 26S proteasome degrades TP73 polyubiquitinated by ITCH - Rattus norvegicus [BlackBoxEvent:R-RNO-8957265] 26S proteasome degrades TP73 polyubiquitinated by ITCH - Rattus norvegicus [BlackBoxEvent:R-RNO-8957265] 26S proteasome degrades TP73 polyubiquitinated by ITCH - Rattus norvegicus [BlackBoxEvent:R-RNO-8957265] 26S proteasome degrades TP73 polyubiquitinated by ITCH - Rattus norvegicus [BlackBoxEvent:R-RNO-8957265] 26S proteasome degrades TP73 polyubiquitinated by ITCH - Rattus norvegicus [BlackBoxEvent:R-RNO-8957265] 26S proteasome degrades TP73 polyubiquitinated by ITCH - Rattus norvegicus [BlackBoxEvent:R-RNO-8957265] 26S proteasome degrades TP73 polyubiquitinated by ITCH - Rattus norvegicus [Reaction:R-RNO-9929486] SPOP-mediated degradation of CD274 by 26S Proteosome - Rattus norvegicus [Reaction:R-RNO-9929486] SPOP-mediated degradation of CD274 by 26S Proteosome - Rattus norvegicus [Reaction:R-RNO-9929486] SPOP-mediated degradation of CD274 by 26S Proteosome - Rattus norvegicus [Reaction:R-RNO-9931314] Proteasomal degradation of polyUb-p-S195-CD274 - Rattus norvegicus [Reaction:R-RNO-9929353] Deubiquitination of CD274 - Rattus norvegicus [Reaction:R-RNO-9929352] Ubiquitinated CD274 is degraded by the 26S proteasome - Rattus norvegicus [Reaction:R-RNO-9929352] Ubiquitinated CD274 is degraded by the 26S proteasome - Rattus norvegicus [Reaction:R-RNO-9929352] Ubiquitinated CD274 is degraded by the 26S proteasome - Rattus norvegicus [BlackBoxEvent:R-RNO-9817400] CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex - Rattus norvegicus [BlackBoxEvent:R-RNO-75825] Proteasome mediated degradation of Cyclin D1 - Rattus norvegicus [BlackBoxEvent:R-RNO-75825] Proteasome mediated degradation of Cyclin D1 - Rattus norvegicus [BlackBoxEvent:R-RNO-75825] Proteasome mediated degradation of Cyclin D1 - Rattus norvegicus [BlackBoxEvent:R-RNO-8854071] Proteasome-mediated degradation of PolyUb-FBXL7 - Rattus norvegicus [BlackBoxEvent:R-RNO-8854071] Proteasome-mediated degradation of PolyUb-FBXL7 - Rattus norvegicus [BlackBoxEvent:R-RNO-8854071] Proteasome-mediated degradation of PolyUb-FBXL7 - Rattus norvegicus [BlackBoxEvent:R-RNO-69016] Ubiquitinated Cdc6 is degraded by the proteasome - Rattus norvegicus [BlackBoxEvent:R-RNO-9766223] Proteasome-dependent degradation of ubiquitinated CDH1 - Rattus norvegicus [BlackBoxEvent:R-RNO-2130282] Degradation of ubiquitinated beta catenin by the proteasome - Rattus norvegicus [BlackBoxEvent:R-RNO-2130282] Degradation of ubiquitinated beta catenin by the proteasome - Rattus norvegicus [BlackBoxEvent:R-RNO-2130282] Degradation of ubiquitinated beta catenin by the proteasome - Rattus norvegicus [BlackBoxEvent:R-RNO-2130282] Degradation of ubiquitinated beta catenin by the proteasome - Rattus norvegicus [BlackBoxEvent:R-RNO-4641256] Ubiquitinated AXIN is degraded by the proteasome - Rattus norvegicus [Reaction:R-RNO-3640872] USP34 deubiquitinates AXIN1,AXIN2 - Rattus norvegicus [BlackBoxEvent:R-RNO-68948] Ubiquitinated Orc1 is degraded by the proteasome - Rattus norvegicus [BlackBoxEvent:R-RNO-68948] Ubiquitinated Orc1 is degraded by the proteasome - Rattus norvegicus [BlackBoxEvent:R-RNO-68948] Ubiquitinated Orc1 is degraded by the proteasome - Rattus norvegicus [BlackBoxEvent:R-RNO-1234159] Proteasome proteolyzes ub-HIF-alpha - Rattus norvegicus [BlackBoxEvent:R-RNO-8850992] Proteasome degrades polyubiquitinated PTEN - Rattus norvegicus [BlackBoxEvent:R-RNO-8850992] Proteasome degrades polyubiquitinated PTEN - Rattus norvegicus [BlackBoxEvent:R-RNO-8850992] Proteasome degrades polyubiquitinated PTEN - Rattus norvegicus [BlackBoxEvent:R-RNO-983150] Proteasomal cleavage of substrate - Rattus norvegicus [BlackBoxEvent:R-RNO-174157] Degradation of multiubiquitinated Cyclin B - Rattus norvegicus [BlackBoxEvent:R-RNO-174157] Degradation of multiubiquitinated Cyclin B - Rattus norvegicus [BlackBoxEvent:R-RNO-174157] Degradation of multiubiquitinated Cyclin B - Rattus norvegicus [BlackBoxEvent:R-RNO-174157] Degradation of multiubiquitinated Cyclin B - Rattus norvegicus [BlackBoxEvent:R-RNO-174202] Degradation of multiubiquitinated Securin - Rattus norvegicus [BlackBoxEvent:R-RNO-174202] Degradation of multiubiquitinated Securin - Rattus norvegicus [BlackBoxEvent:R-RNO-174202] Degradation of multiubiquitinated Securin - Rattus norvegicus [BlackBoxEvent:R-RNO-174202] Degradation of multiubiquitinated Securin - Rattus norvegicus [BlackBoxEvent:R-RNO-174203] SCF-mediated degradation of Emi1 - Rattus norvegicus [BlackBoxEvent:R-RNO-174203] SCF-mediated degradation of Emi1 - Rattus norvegicus [BlackBoxEvent:R-RNO-174203] SCF-mediated degradation of Emi1 - Rattus norvegicus [BlackBoxEvent:R-RNO-174203] SCF-mediated degradation of Emi1 - Rattus norvegicus [BlackBoxEvent:R-RNO-174105] Degradation of multiubiquitinated cell cycle proteins - Rattus norvegicus [BlackBoxEvent:R-RNO-174105] Degradation of multiubiquitinated cell cycle proteins - Rattus norvegicus [BlackBoxEvent:R-RNO-174105] Degradation of multiubiquitinated cell cycle proteins - Rattus norvegicus [BlackBoxEvent:R-RNO-174105] Degradation of multiubiquitinated cell cycle proteins - Rattus norvegicus [BlackBoxEvent:R-RNO-174255] Degradation multiubiquitinated Cyclin A - Rattus norvegicus [BlackBoxEvent:R-RNO-174255] Degradation multiubiquitinated Cyclin A - Rattus norvegicus [BlackBoxEvent:R-RNO-174255] Degradation multiubiquitinated Cyclin A - Rattus norvegicus [BlackBoxEvent:R-RNO-174255] Degradation multiubiquitinated Cyclin A - Rattus norvegicus [BlackBoxEvent:R-RNO-264458] Proteasome mediated degradation of COP1 - Rattus norvegicus [BlackBoxEvent:R-RNO-264458] Proteasome mediated degradation of COP1 - Rattus norvegicus [BlackBoxEvent:R-RNO-264458] Proteasome mediated degradation of COP1 - Rattus norvegicus [BlackBoxEvent:R-RNO-264458] Proteasome mediated degradation of COP1 - Rattus norvegicus [Reaction:R-RNO-5690152] USP5 cleaves polyubiquitin - Rattus norvegicus [Reaction:R-RNO-6781764] USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 - Rattus norvegicus [Reaction:R-RNO-6781764] USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 - Rattus norvegicus [Reaction:R-RNO-6781764] USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 - Rattus norvegicus [Reaction:R-RNO-6782628] USP8 deubiquitinates STAM2:HGS - Rattus norvegicus [Reaction:R-RNO-6782628] USP8 deubiquitinates STAM2:HGS - Rattus norvegicus [Reaction:R-RNO-6782628] USP8 deubiquitinates STAM2:HGS - Rattus norvegicus [BlackBoxEvent:R-RNO-9755303] 26S proteasome degrades HIFalpha - Rattus norvegicus [Reaction:R-RNO-8875443] USP8 deubiquitinates LRIG1 - Rattus norvegicus [BlackBoxEvent:R-RNO-5635868] ub-GLI is degraded by the proteasome - Rattus norvegicus [BlackBoxEvent:R-RNO-5607731] 26S proteasome processes p-7S-p100:RELB to form p52:RELB - Rattus norvegicus [BlackBoxEvent:R-RNO-5607731] 26S proteasome processes p-7S-p100:RELB to form p52:RELB - Rattus norvegicus [BlackBoxEvent:R-RNO-5607731] 26S proteasome processes p-7S-p100:RELB to form p52:RELB - Rattus norvegicus [BlackBoxEvent:R-RNO-5607731] 26S proteasome processes p-7S-p100:RELB to form p52:RELB - Rattus norvegicus [BlackBoxEvent:R-RNO-5357845] K63polyUb-RIPK1 is deubiquitinated - Rattus norvegicus [BlackBoxEvent:R-RNO-8854044] Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 - Rattus norvegicus [BlackBoxEvent:R-RNO-8854044] Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 - Rattus norvegicus [BlackBoxEvent:R-RNO-8854044] Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 - Rattus norvegicus [BlackBoxEvent:R-RNO-1168640] Ubiquitinated IkB is degraded - Rattus norvegicus [BlackBoxEvent:R-RNO-1168640] Ubiquitinated IkB is degraded - Rattus norvegicus [BlackBoxEvent:R-RNO-1168640] Ubiquitinated IkB is degraded - Rattus norvegicus [BlackBoxEvent:R-RNO-209061] Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex - Rattus norvegicus [BlackBoxEvent:R-RNO-4641260] Ubiquitinated DVL1 is degraded by the proteasome - Rattus norvegicus [BlackBoxEvent:R-RNO-1504193] Ubiquitinated DVL is degraded by the proteasome - Rattus norvegicus [Reaction:R-RNO-1358795] Deubiquitination of RNF41 by P-USP8 - Rattus norvegicus [Reaction:R-RNO-6807206] USP13 and OTUD3 deubiquitinate PTEN - Rattus norvegicus [Reaction:R-RNO-6807206] USP13 and OTUD3 deubiquitinate PTEN - Rattus norvegicus [Reaction:R-RNO-6807206] USP13 and OTUD3 deubiquitinate PTEN - Rattus norvegicus [BlackBoxEvent:R-RNO-936390] CYLD mediated deubiquitination of DDX58 (RIG-I) - Rattus norvegicus [Reaction:R-RNO-9674127] USP30 deubiquitinates ATM dimer:Ub-p-PEX5 - Rattus norvegicus [BlackBoxEvent:R-RNO-9750942] USP14 deubiquitinates NLRC5 - Rattus norvegicus [BlackBoxEvent:R-RNO-9750942] USP14 deubiquitinates NLRC5 - Rattus norvegicus [BlackBoxEvent:R-RNO-9750942] USP14 deubiquitinates NLRC5 - Rattus norvegicus [BlackBoxEvent:R-RNO-5684273] 3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 - Rattus norvegicus [BlackBoxEvent:R-RNO-5684273] 3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 - Rattus norvegicus [BlackBoxEvent:R-RNO-5684273] 3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 - Rattus norvegicus [BlackBoxEvent:R-RNO-5684273] 3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 - Rattus norvegicus [BlackBoxEvent:R-RNO-5684273] 3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 - Rattus norvegicus [BlackBoxEvent:R-RNO-5684273] 3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 - Rattus norvegicus [BlackBoxEvent:R-RNO-5684273] 3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 - Rattus norvegicus [BlackBoxEvent:R-RNO-5684273] 3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 - Rattus norvegicus [BlackBoxEvent:R-RNO-5684273] 3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 - Rattus norvegicus [BlackBoxEvent:R-RNO-179421] Degradation of multiubiquitinated Nek2A - Rattus norvegicus [BlackBoxEvent:R-RNO-179421] Degradation of multiubiquitinated Nek2A - Rattus norvegicus [BlackBoxEvent:R-RNO-179421] Degradation of multiubiquitinated Nek2A - Rattus norvegicus [BlackBoxEvent:R-RNO-8852354] GTSE1 facilitates proteasome-mediated degradation of TP53 - Rattus norvegicus [Reaction:R-RNO-9033491] USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin - Rattus norvegicus [BlackBoxEvent:R-RNO-3640874] Ub-RibC-AXIN is degraded by the proteasome - Rattus norvegicus [Reaction:R-RNO-870437] USP9X (FAM) deubiquitinates SMAD4 - Rattus norvegicus [BlackBoxEvent:R-RNO-9818975] CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex - Rattus norvegicus
schemaClass	DefinedSet
species	[Species:48895] Rattus norvegicus
stId	R-RNO-113595

Referrals

(hasComponent)	[Complex:R-RNO-9033504] Ub:PEX5L [cytosol] [Complex:R-RNO-6782795] USP5:Ub [cytosol] [Complex:R-RNO-6782592] UCHL1,UCHL3:Ub [cytosol] [Complex:R-RNO-8864229] Ub:E2 (UBA6 substrate) [cytosol] [Complex:R-RNO-8852066] Ub-Cys625-UBA6 [cytosol] [Complex:R-RNO-8852251] Ub:E2 (UBA1 substrate) [cytosol] [Complex:R-RNO-8852063] Ub-Cys632-UBA1 [cytosol] [Complex:R-RNO-9033498] Ub:PEX5L [peroxisomal membrane] [Complex:R-RNO-8942547] Ub:UBE2D1,UBE2D2,UBE2D3, UBE2E1,UBE2N [cytosol] [Complex:R-RNO-8942552] Ub:UBE2N [cytosol] [Complex:R-RNO-8953915] Ub:UBE2D1,2,3 [cytosol] [Complex:R-RNO-8869163] EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] [Complex:R-RNO-9929485] polyUb-PDL1:SPOP:CUL3:RBX1 [cytosol] [Complex:R-RNO-9931275] polyUb-p-S195-CD274 [cytosol] [Complex:R-RNO-9929359] polyUb-p184,T189-CD274:BTRC E3 complex [cytosol] [Complex:R-RNO-8939319] Ub:UBE2D1 [cytosol] [Complex:R-RNO-8939330] Ub:UBE2D2 [cytosol] [Complex:R-RNO-8867287] Ub-unfolded protein:(GlcNAc)2 (Man)9-5 [endoplasmic reticulum quality control compartment] [Complex:R-RNO-8866894] Ub-unfolded protein:(GlcNAc)2 (Man)9-5 [cytosol] [Complex:R-RNO-177997] multi-ubiquitinated phospho-(T286) Cyclin D1 [cytosol] [Complex:R-RNO-3000337] Ub-p-8S,3T-BORA [cytosol] [Complex:R-RNO-5654363] Ub-Activated FGFR4 complex:Ub-p-FRS2 [plasma membrane] [Complex:R-RNO-5654357] Ub-Activated FGFR1 complex:Ub-p-FRS2 [plasma membrane] [Complex:R-RNO-209535] Ubiquitinated phospho-IkB [cytosol] [Complex:R-RNO-204940] K63 linked polyubiquitin chain [cytosol] [Complex:R-RNO-5654362] Ub-Activated FGFR3 complex:Ub-p-FRS2 [plasma membrane] [Complex:R-RNO-68570] ubiquitinated Cdc6 [cytosol] [Complex:R-RNO-206877] NFKB1:RELA:p-S32,S36-NFKBIA:Ub [cytosol] [Complex:R-RNO-1911536] Ub-DTX:ITCH [cytosol] [Complex:R-RNO-1977297] Ub-ERBB4jmAcyt1s80:NEDD4 [cytosol] [Complex:R-RNO-1253293] Ub-ERBB4:WWP1/ITCH [plasma membrane] [Complex:R-RNO-5654360] Ub-Activated FGFR2 complex:Ub-p-FRS2 [plasma membrane] [Complex:R-RNO-1370875] Ub-(Y55/Y227)p-SPRY2 [plasma membrane] [Complex:R-RNO-934572] Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] [Complex:R-RNO-2130284] ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] [Complex:R-RNO-1918081] Ub-ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] [Complex:R-RNO-1358729] NRG1/2:Ub-p-10Y-ERBB3:p-ERBB2 [plasma membrane] [Complex:R-RNO-1358735] Ub-ERBB3 [plasma membrane] [Complex:R-RNO-1358737] Ub-RNF41 [cytosol] [Complex:R-RNO-1918083] Ub-ERBB2:ERBIN:Ub-HSP90:CDC37 [plasma membrane] [Complex:R-RNO-182967] Ub-p-Y53/55-SPRY1/2 [cytosol] [Complex:R-RNO-182945] EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] [Complex:R-RNO-182915] Ub-Beta-Pix:CDC42:GTP [cytosol] [Complex:R-RNO-182930] EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL [plasma membrane] [Complex:R-RNO-1234113] ub-hydroxyPro-HIF-alpha [cytosol] [Complex:R-RNO-8938763] Ub:UBE2L3 [cytosol] [Complex:R-RNO-8937453] Ub:UBE2D3 [cytosol] [Complex:R-RNO-1234116] UBE2D1,2,3:Ubiquitin [cytosol] [Complex:R-RNO-9833154] multiubiquitinated STAT2 [cytosol] [Complex:R-RNO-976164] E1 bound ubiquitin [cytosol] [Complex:R-RNO-976165] Ubiquitin:E2 conjugating enzymes [cytosol] [Complex:R-RNO-983130] Ub:substrate [cytosol] [Complex:R-RNO-8866534] Ub-misfolded nascent CFTR [cytosol] [Complex:R-RNO-9640491] Ub:UBE2N:UBE2V1 [cytosol] [Complex:R-RNO-9835021] Ub:Ub-UBE2D2,UBE2D3,UBE2N:UBE2V1,UBE2L3 [cytosol] [Complex:R-RNO-174061] SCF-associated multiubiquitinated Emi1complexes [cytosol] [Complex:R-RNO-174222] multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] [Complex:R-RNO-179414] Multiubiquitinated Nek2A [cytosol] [Complex:R-RNO-174248] multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] [Complex:R-RNO-174131] multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] [Complex:R-RNO-349433] ubiquitinated phospho-COP1(ser-387) [cytosol] [Complex:R-RNO-2187371] Ub-SMAD3 [cytosol] [Complex:R-RNO-2176443] Ub-SMAD2 [cytosol] [Complex:R-RNO-2169047] TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7 [plasma membrane] [Complex:R-RNO-2160934] Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1 [cell junction]
(input)	[BlackBoxEvent:R-RNO-450580] AUF1 (hnRNP D0) is ubiquitinylated [Reaction:R-RNO-8956026] CUL9:RBX1 ubiquitinates BIRC5 [Reaction:R-RNO-8852132] Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol [Reaction:R-RNO-8852134] UBA1 adenylates ubiquitin in the cytosol [Reaction:R-RNO-5362412] SYVN1 ubiquitinates Hh C-terminal fragments [Reaction:R-RNO-9759154] TRIM21 ubiquitinates SQSTM1 [Reaction:R-RNO-9755304] MUL1 ubiquitinates UBXN7 [Reaction:R-RNO-2682349] RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels [Reaction:R-RNO-8866546] RNF5 and RNF185 ubiquitinate misfolded CFTR [Reaction:R-RNO-9766645] CUL3:RBX1 ubiquitinates KEAP1 [Reaction:R-RNO-9759172] KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer [Reaction:R-RNO-9755505] KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 [Reaction:R-RNO-8875183] CBL monoubiquitinates activated MET [Reaction:R-RNO-8956684] ITCH polyubiquitinates TP73 [Reaction:R-RNO-5610742] SCF(beta-TrCP) ubiquitinates p-GLI1 [Reaction:R-RNO-5635864] NUMB:ITCH ubiquitinates GLI1 [Reaction:R-RNO-5691108] SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 [Reaction:R-RNO-9929490] CD274 ubiquitination by SPOP:CUL3:RBX1 complex [Reaction:R-RNO-9929350] Ubiquitination of CD274 by BTRC-SCF E3-ligase complex [BlackBoxEvent:R-RNO-9861640] CTLH E3 ligase ubiquitinates PKM-1 [BlackBoxEvent:R-RNO-9861563] CTLH E3 ligase ubiquitinates LDHA [Reaction:R-RNO-8854041] SCF-FBXL7 ubiquitinates AURKA [Reaction:R-RNO-8854051] SCF-FBXL18 ubiquitinates FBXL7 [Reaction:R-RNO-3000335] SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA [Reaction:R-RNO-5654684] CBL ubiquitinates FRS2 and FGFR4 [BlackBoxEvent:R-RNO-1168643] SCF-beta-TrCP ubiquitinylates IkB [Reaction:R-RNO-5654672] CBL ubiquitinates FRS2 and FGFR1 [Reaction:R-RNO-209536] IkB is ubiquitinated and degraded [BlackBoxEvent:R-RNO-209566] TRAF6 is auto-ubiquitinated [BlackBoxEvent:R-RNO-9958873] Cell-to-cell contact through homophilic cadherin interactions inhibits RAC1/CDC42 ubiquitination [Reaction:R-RNO-5654679] CBL ubiquitinates FRS2 and FGFR3 [Reaction:R-RNO-69015] Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex [Reaction:R-RNO-3134946] DDX41 ubiquitination by TRIM21 [Reaction:R-RNO-3134804] STING ubiquitination by TRIM32 or TRIM56 [Reaction:R-RNO-8948709] DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 [Reaction:R-RNO-209063] Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex [Reaction:R-RNO-9021523] WWP2 ubiquitinates NOTCH3 [Reaction:R-RNO-1912357] ITCH ubiquitinates DTX [Reaction:R-RNO-5610746] SCF(beta-TrCP) ubiquitinates p-GLI3 [Reaction:R-RNO-1977296] NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer [Reaction:R-RNO-1253282] ERBB4 ubiquitination by WWP1/ITCH [Reaction:R-RNO-5654677] CBL ubiquitinates FRS2 and FGFR2 [Reaction:R-RNO-934604] Phosphorylated SPRY2 is ubiquitinated by CBL [BlackBoxEvent:R-RNO-9766227] MDM2 mediates CDH1 ubiquitination [Reaction:R-RNO-9934753] CBLL1 ubiquitinates CDH1 [Reaction:R-RNO-2130286] Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) [Reaction:R-RNO-4641246] ZNRF3 autoubiquitinates to promote its internalization [Reaction:R-RNO-4641129] AXIN is ubiquitinated by SMURF2 [Reaction:R-RNO-1504190] DVL is ubiquitinated by CUL3:KLHL12:RBX1 [Reaction:R-RNO-4641159] DVL1 is ubiquitinated by HECW1 [Reaction:R-RNO-3640861] RNF146 ubiquitinates ADP-ribosylated AXIN [Reaction:R-RNO-4641253] ZNRF3 ubiquitinates FZD to promote its downregulation [Reaction:R-RNO-4608852] SMURF1/2 ubiquitinates PRICKLE1 [Reaction:R-RNO-1918095] CUL5 mediates ubiquitination of ERBB2 [Reaction:R-RNO-1358790] RNF41 ubiquitinates ERBB3 [Reaction:R-RNO-1358792] RNF41 ubiquitinates activated ERBB3 [Reaction:R-RNO-1358789] Self-ubiquitination of RNF41 [Reaction:R-RNO-1918092] CHIP (STUB1) mediates ubiquitination of ERBB2 [Reaction:R-RNO-5674022] BRAP autoubiquitinates [Reaction:R-RNO-5658424] KBTBD7:CUL3:RBX1 ubiquitinates NF1 [Reaction:R-RNO-183051] CBL ubiquitinates Sprouty [Reaction:R-RNO-183089] CBL binds and ubiquitinates phosphorylated Sprouty [Reaction:R-RNO-183036] Ubiquitination of stimulated EGFR (CBL:GRB2) [Reaction:R-RNO-183084] CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix [Reaction:R-RNO-182986] CBL-mediated ubiquitination of CIN85 [Reaction:R-RNO-182993] Ubiquitination of stimulated EGFR (CBL) [Reaction:R-RNO-8848829] CBL autoubiquitinates [Reaction:R-RNO-8948775] MKRN1 polyubiquitinates PTEN [Reaction:R-RNO-8948832] RNF146 polyubiquitinates PARylated PTEN [Reaction:R-RNO-8851011] TRIM27 polyubiquitinates PTEN [Reaction:R-RNO-6807134] NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN [Reaction:R-RNO-6807106] PTEN undergoes monoubiquitination [BlackBoxEvent:R-RNO-9688831] STUB1 ubiquitinates RIPK3 at K55, K363 [Polymerisation:R-RNO-450358] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation [BlackBoxEvent:R-RNO-975147] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane [BlackBoxEvent:R-RNO-9823939] IKK? (IKBKE) is ubiquitinated within the activated TLR4 [BlackBoxEvent:R-RNO-9823904] TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 [BlackBoxEvent:R-RNO-2213017] Auto-ubiquitination of TRAF3 [BlackBoxEvent:R-RNO-5362500] TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 [BlackBoxEvent:R-RNO-9758604] Ubiquitination of IKBKG by TRAF6 [Reaction:R-RNO-983153] E1 mediated ubiquitin activation [Reaction:R-RNO-2160935] SMURF1 ubiquitinates RHOA [Reaction:R-RNO-9664888] ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 [BlackBoxEvent:R-RNO-936942] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 [Polymerisation:R-RNO-936986] Activated TRAF6 synthesizes unanchored polyubiquitin chains [BlackBoxEvent:R-RNO-9645414] Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer [Polymerisation:R-RNO-9645394] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation [BlackBoxEvent:R-RNO-9750946] TRAF2,6 ubiquitinates NLRC5 [BlackBoxEvent:R-RNO-936952] Auto ubiquitination of TRAF6 bound to the activated TLR4 complex [Reaction:R-RNO-5684250] SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 [Reaction:R-RNO-174159] Ubiquitination of Emi1 by SCF-beta-TrCP [Reaction:R-RNO-179417] Multiubiquitination of Nek2A [Reaction:R-RNO-174227] Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex [Reaction:R-RNO-174144] Ubiquitination of Securin by phospho-APC/C:Cdc20 complex [Reaction:R-RNO-174195] Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex [Reaction:R-RNO-174104] Ubiquitination of Cyclin A by APC/C:Cdc20 complex [Reaction:R-RNO-264444] Autoubiquitination of phospho-COP1(Ser-387 ) [Reaction:R-RNO-2187368] STUB1 (CHIP) ubiquitinates SMAD3 [Reaction:R-RNO-173542] SMURF2 ubiquitinates SMAD2
(output)	[BlackBoxEvent:R-RNO-5687112] MAPK6 is degraded by the 26S proteasome [Reaction:R-RNO-9033491] USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin [BlackBoxEvent:R-RNO-450466] AUF1:mRNA complex is degraded [BlackBoxEvent:R-RNO-9954728] The proteasome degrades the K48-polyubiquitinated alanine-tailed nascent peptide [Reaction:R-RNO-8865182] OTUD7A hydrolyses K11diUb [Reaction:R-RNO-5690152] USP5 cleaves polyubiquitin [Reaction:R-RNO-6781764] USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 [Reaction:R-RNO-6782628] USP8 deubiquitinates STAM2:HGS [BlackBoxEvent:R-RNO-9755303] 26S proteasome degrades HIFalpha [BlackBoxEvent:R-RNO-5362448] Hh C-terminal fragments are degraded by the proteasome [BlackBoxEvent:R-RNO-9934893] Proteolysis of K48polyUb-K,p-S-PER1,2,3 [BlackBoxEvent:R-RNO-9755306] ub UBXN7 is degraded by the 26S proteasome [BlackBoxEvent:R-RNO-8866553] misfolded CFTR is degraded by the 26S proteasome [BlackBoxEvent:R-RNO-8932355] 26S proteasome degrades Ub-NFE2L2 [BlackBoxEvent:R-RNO-8952408] Polyubiquitinated RUNX3 is degraded by the proteasome [Reaction:R-RNO-8875443] USP8 deubiquitinates LRIG1 [BlackBoxEvent:R-RNO-8957265] 26S proteasome degrades TP73 polyubiquitinated by ITCH [BlackBoxEvent:R-RNO-5635868] ub-GLI is degraded by the proteasome [BlackBoxEvent:R-RNO-5607731] 26S proteasome processes p-7S-p100:RELB to form p52:RELB [Reaction:R-RNO-9929486] SPOP-mediated degradation of CD274 by 26S Proteosome [Reaction:R-RNO-9931314] Proteasomal degradation of polyUb-p-S195-CD274 [Reaction:R-RNO-9929353] Deubiquitination of CD274 [Reaction:R-RNO-9929352] Ubiquitinated CD274 is degraded by the 26S proteasome [BlackBoxEvent:R-RNO-9817400] CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex [BlackBoxEvent:R-RNO-9818975] CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex [BlackBoxEvent:R-RNO-5357845] K63polyUb-RIPK1 is deubiquitinated [BlackBoxEvent:R-RNO-75825] Proteasome mediated degradation of Cyclin D1 [BlackBoxEvent:R-RNO-8854071] Proteasome-mediated degradation of PolyUb-FBXL7 [BlackBoxEvent:R-RNO-8854044] Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 [BlackBoxEvent:R-RNO-1168640] Ubiquitinated IkB is degraded [BlackBoxEvent:R-RNO-69016] Ubiquitinated Cdc6 is degraded by the proteasome [BlackBoxEvent:R-RNO-209061] Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex [BlackBoxEvent:R-RNO-9766223] Proteasome-dependent degradation of ubiquitinated CDH1 [BlackBoxEvent:R-RNO-2130282] Degradation of ubiquitinated beta catenin by the proteasome [BlackBoxEvent:R-RNO-3640874] Ub-RibC-AXIN is degraded by the proteasome [BlackBoxEvent:R-RNO-4641260] Ubiquitinated DVL1 is degraded by the proteasome [BlackBoxEvent:R-RNO-1504193] Ubiquitinated DVL is degraded by the proteasome [BlackBoxEvent:R-RNO-4641256] Ubiquitinated AXIN is degraded by the proteasome [Reaction:R-RNO-3640872] USP34 deubiquitinates AXIN1,AXIN2 [Reaction:R-RNO-1358795] Deubiquitination of RNF41 by P-USP8 [BlackBoxEvent:R-RNO-68948] Ubiquitinated Orc1 is degraded by the proteasome [BlackBoxEvent:R-RNO-1234159] Proteasome proteolyzes ub-HIF-alpha [BlackBoxEvent:R-RNO-8850992] Proteasome degrades polyubiquitinated PTEN [Reaction:R-RNO-6807206] USP13 and OTUD3 deubiquitinate PTEN [BlackBoxEvent:R-RNO-936390] CYLD mediated deubiquitination of DDX58 (RIG-I) [BlackBoxEvent:R-RNO-983150] Proteasomal cleavage of substrate [Reaction:R-RNO-9674127] USP30 deubiquitinates ATM dimer:Ub-p-PEX5 [BlackBoxEvent:R-RNO-9750942] USP14 deubiquitinates NLRC5 [BlackBoxEvent:R-RNO-5684273] 3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 [Reaction:R-RNO-870437] USP9X (FAM) deubiquitinates SMAD4 [BlackBoxEvent:R-RNO-174157] Degradation of multiubiquitinated Cyclin B [BlackBoxEvent:R-RNO-174202] Degradation of multiubiquitinated Securin [BlackBoxEvent:R-RNO-174203] SCF-mediated degradation of Emi1 [BlackBoxEvent:R-RNO-174105] Degradation of multiubiquitinated cell cycle proteins [BlackBoxEvent:R-RNO-179421] Degradation of multiubiquitinated Nek2A [BlackBoxEvent:R-RNO-174255] Degradation multiubiquitinated Cyclin A [BlackBoxEvent:R-RNO-264458] Proteasome mediated degradation of COP1 [BlackBoxEvent:R-RNO-8852354] GTSE1 facilitates proteasome-mediated degradation of TP53
(inferredTo)	[DefinedSet:R-HSA-113595] Ub [cytosol]

© 2026 Reactome

Cite Us!