Reactome | KBTBD7:CUL3:RBX1 ubiquitinates NF1

Schema > Reaction > Entries

KBTBD7:CUL3:RBX1 ubiquitinates NF1 Show undefined attributes

catalystActivity	[CatalystActivity:10181347] ubiquitin protein ligase activity of KBTBD7:CUL3:RBX1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10181349
displayName	KBTBD7:CUL3:RBX1 ubiquitinates NF1
eventOf	[Pathway:R-RNO-5658442] Regulation of RAS by GAPs - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-RNO-5658430] NF1 is degraded by the proteasome - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-5658424] KBTBD7:CUL3:RBX1 ubiquitinates NF1 - Homo sapiens
input	[Complex:R-RNO-5658232] SPRED dimer:NF1 [plasma membrane] [DefinedSet:R-RNO-113595] Ub [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	KBTBD7:CUL3:RBX1 ubiquitinates NF1
output	[Complex:R-RNO-5658420] SPRED dimer:ub-NF1 [plasma membrane]
precedingEvent	[Reaction:R-RNO-5658438] SPRED dimer binds NF1 - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5658424
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-5658442] Regulation of RAS by GAPs
(precedingEvent)	[BlackBoxEvent:R-RNO-5658430] NF1 is degraded by the proteasome
(inferredTo)	[Reaction:R-HSA-5658424] KBTBD7:CUL3:RBX1 ubiquitinates NF1

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