Reactome | TRIM21 ubiquitinates SQSTM1

Schema > Reaction > Entries

catalystActivity	[CatalystActivity:10215174] ubiquitin protein ligase activity of TRIM21 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10215176
displayName	TRIM21 ubiquitinates SQSTM1
eventOf	[Pathway:R-RNO-9755511] KEAP1-NFE2L2 pathway - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9759154] TRIM21 ubiquitinates SQSTM1 - Homo sapiens
input	[EntityWithAccessionedSequence:R-RNO-193937] SQSTM1 [cytosol] 3 × [DefinedSet:R-RNO-113595] Ub [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	TRIM21 ubiquitinates SQSTM1
output	[EntityWithAccessionedSequence:R-RNO-9759088] K7 ub-SQSTM1 [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9759154
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-RNO-9755511] KEAP1-NFE2L2 pathway
(inferredTo)	[Reaction:R-HSA-9759154] TRIM21 ubiquitinates SQSTM1

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