Reactome | Proteasome proteolyzes ub-HIF-alpha

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Proteasome proteolyzes ub-HIF-alpha Show undefined attributes

catalystActivity	[CatalystActivity:10103487] endopeptidase activity of 26S proteasome [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10151604
displayName	Proteasome proteolyzes ub-HIF-alpha
eventOf	[Pathway:R-RNO-1234176] Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-1234159] Proteasome proteolyzes ub-HIF-alpha - Homo sapiens
input	[DefinedSet:R-RNO-8932465] ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Proteasome proteolyzes ub-HIF-alpha
output	[DefinedSet:R-RNO-113595] Ub [cytosol] [DefinedSet:R-RNO-8932481] VBC complex (with or without LIMD1) [cytosol]
precedingEvent	[BlackBoxEvent:R-RNO-1234175] ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol - Rattus norvegicus [Reaction:R-RNO-1234163] Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48895] Rattus norvegicus
stId	R-RNO-1234159
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-1234176] Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
(inferredTo)	[BlackBoxEvent:R-HSA-1234159] Proteasome proteolyzes ub-HIF-alpha