Reactome | misfolded CFTR is degraded by the 26S proteasome

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misfolded CFTR is degraded by the 26S proteasome Show undefined attributes

catalystActivity	[CatalystActivity:10103487] endopeptidase activity of 26S proteasome [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10200871
displayName	misfolded CFTR is degraded by the 26S proteasome
eventOf	[Pathway:R-RNO-382556] ABC-family protein mediated transport - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-8866553] misfolded CFTR is degraded by the 26S proteasome - Homo sapiens
input	[Complex:R-RNO-8866534] Ub-misfolded nascent CFTR [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	misfolded CFTR is degraded by the 26S proteasome
output	[DefinedSet:R-RNO-113595] Ub [cytosol]
precedingEvent	[Reaction:R-RNO-8866542] VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48895] Rattus norvegicus
stId	R-RNO-8866553
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-382556] ABC-family protein mediated transport
(inferredTo)	[BlackBoxEvent:R-HSA-8866553] misfolded CFTR is degraded by the 26S proteasome

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