Reactome | Ub-misfolded nascent CFTR [cytosol]

Schema > Complex > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-RNO-8866535] Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] - Rattus norvegicus
consumedByEvent	[BlackBoxEvent:R-RNO-8866553] misfolded CFTR is degraded by the 26S proteasome - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10200822
displayName	Ub-misfolded nascent CFTR [cytosol]
hasComponent	[EntityWithAccessionedSequence:R-RNO-8868730] misfolded CFTR [endoplasmic reticulum membrane] [DefinedSet:R-RNO-113595] Ub [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-8866534] Ub-misfolded nascent CFTR [cytosol] - Homo sapiens [Complex:R-HSA-9665106] PolyUb-misfolded nascent CFTR [cytosol] - Homo sapiens
maxDepth	3
memberOf	[DefinedSet:R-RNO-9641117] Ub-Misfolded Proteins [cytosol] - Rattus norvegicus
name	Ub-misfolded nascent CFTR
producedByEvent	[Reaction:R-RNO-8866542] VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol - Rattus norvegicus
schemaClass	Complex
species	[Species:48895] Rattus norvegicus
stId	R-RNO-8866534
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[BlackBoxEvent:R-RNO-8866553] misfolded CFTR is degraded by the 26S proteasome
(output)	[Reaction:R-RNO-8866542] VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol
(hasComponent)	[Complex:R-RNO-8866535] Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane]
(hasMember)	[DefinedSet:R-RNO-9641117] Ub-Misfolded Proteins [cytosol] [DefinedSet:R-RNO-9641120] PolyUb-Misfolded Proteins [cytosol]
(inferredTo)	[Complex:R-HSA-8866534] Ub-misfolded nascent CFTR [cytosol] [Complex:R-HSA-9665106] PolyUb-misfolded nascent CFTR [cytosol]