Reactome | CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex

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CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex Show undefined attributes

catalystActivity	[CatalystActivity:10216589] Met1-linked polyubiquitin deubiquitinase activity of TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane]
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10216591
displayName	CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex
eventOf	[Pathway:R-RNO-5357905] Regulation of TNFR1 signaling - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-9818975] CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex - Homo sapiens
input	[Complex:R-RNO-9817363] TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex
output	[CandidateSet:R-RNO-5357900] BIRC2,3,4 [cytosol] [Complex:R-RNO-9796690] CYLD:SPATA2:LUBAC [cytosol] [Complex:R-RNO-140946] TNF-?:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] [DefinedSet:R-RNO-113595] Ub [cytosol]
precedingEvent	[BlackBoxEvent:R-RNO-9817362] SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex - Rattus norvegicus
regulatedBy	[NegativeRegulation:10176612] Negative regulation by 'p-S418-CYLD [cytosol]'
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9818975
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-5357905] Regulation of TNFR1 signaling
(inferredTo)	[BlackBoxEvent:R-HSA-9818975] CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex

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