Reactome | Cell-to-cell contact through homophilic cadherin interactions inhibits RAC1/CDC42 ubiquitination

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Cell-to-cell contact through homophilic cadherin interactions inhibits RAC1/CDC42 ubiquitination Show undefined attributes

catalystActivity	[CatalystActivity:10221662] ubiquitin-protein transferase activity of RAC1,(CDC42) Ubiquitin Ligase [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10221674
displayName	Cell-to-cell contact through homophilic cadherin interactions inhibits RAC1/CDC42 ubiquitination
eventOf	[Pathway:R-RNO-9958825] Activation of STAT3 by cadherin engagement - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-9958873] Cell-to-cell contact through homophilic cadherin interactions inhibits RAC1/CDC42 ubiquitination - Homo sapiens
input	[CandidateSet:R-RNO-9959034] RAC1:GTP,(CDC42:GTP) [plasma membrane] 3 × [DefinedSet:R-RNO-113595] Ub [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Cell-to-cell contact through homophilic cadherin interactions inhibits RAC1/CDC42 ubiquitination
output	[CandidateSet:R-RNO-9959465] Ub-RAC1:GTP,(Ub-CDC42:GTP) [plasma membrane]
regulatedBy	[NegativeRegulation:10221675] Negative regulation by 'Engaged CDH1,(CDH11) [plasma membrane]'
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9958873
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-9958825] Activation of STAT3 by cadherin engagement
(inferredTo)	[BlackBoxEvent:R-HSA-9958873] Cell-to-cell contact through homophilic cadherin interactions inhibits RAC1/CDC42 ubiquitination

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