Reactome | CD274 ubiquitination by SPOP:CUL3:RBX1 complex

Schema > Reaction > Entries

CD274 ubiquitination by SPOP:CUL3:RBX1 complex Show undefined attributes

catalystActivity	[CatalystActivity:10219978] ubiquitin protein ligase activity of SPOP:CUL3:RBX1:CD274 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10219980
displayName	CD274 ubiquitination by SPOP:CUL3:RBX1 complex
eventOf	[Pathway:R-RNO-9929491] SPOP-mediated proteasomal degradation of PD-L1(CD274) - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9929490] CD274 ubiquitination by SPOP:CUL3:RBX1 complex - Homo sapiens
input	[Complex:R-RNO-9929493] SPOP:CUL3:RBX1:CD274 [cytosol] 3 × [DefinedSet:R-RNO-113595] Ub [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CD274 ubiquitination by SPOP:CUL3:RBX1 complex
output	[Complex:R-RNO-9929485] polyUb-PDL1:SPOP:CUL3:RBX1 [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9929490
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-9929491] SPOP-mediated proteasomal degradation of PD-L1(CD274)
(inferredTo)	[Reaction:R-HSA-9929490] CD274 ubiquitination by SPOP:CUL3:RBX1 complex

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