Reactome | ZNRF3 ubiquitinates FZD to promote its downregulation

Schema > Reaction > Entries

ZNRF3 ubiquitinates FZD to promote its downregulation Show undefined attributes

catalystActivity	[CatalystActivity:10173670] ubiquitin protein ligase activity of N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6:ZNRF3/RNF43 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10173672
displayName	ZNRF3 ubiquitinates FZD to promote its downregulation
eventOf	[Pathway:R-RNO-4641263] Regulation of FZD by ubiquitination - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-4641253] ZNRF3 ubiquitinates FZD to promote its downregulation - Homo sapiens
input	[Complex:R-RNO-4641177] N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6:ZNRF3/RNF43 [plasma membrane] [DefinedSet:R-RNO-113595] Ub [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ZNRF3 ubiquitinates FZD to promote its downregulation
output	[Complex:R-RNO-4641191] N4GlycoAsn-PalmS-WNT3A:ub-FZD:LRP5/6:ZNRF3/RNF43 [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-4641253
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-4641263] Regulation of FZD by ubiquitination
(inferredTo)	[Reaction:R-HSA-4641253] ZNRF3 ubiquitinates FZD to promote its downregulation

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