Reactome | SMURF1/2 ubiquitinates PRICKLE1

Schema > Reaction > Entries

SMURF1/2 ubiquitinates PRICKLE1 Show undefined attributes

catalystActivity	[CatalystActivity:10173473] ubiquitin protein ligase activity of PARD6A:pp-DVL2:SMURF [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10173475
displayName	SMURF1/2 ubiquitinates PRICKLE1
eventOf	[Pathway:R-RNO-4608870] Asymmetric localization of PCP proteins - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-RNO-4608855] PRICKLE1 is degraded by the proteasome - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-4608852] SMURF1/2 ubiquitinates PRICKLE1 - Homo sapiens
input	[EntityWithAccessionedSequence:R-RNO-4608816] Prickle1 [cytosol] [DefinedSet:R-RNO-113595] Ub [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	SMURF1/2 ubiquitinates PRICKLE1
output	[EntityWithAccessionedSequence:R-RNO-4608820] Prickle1 [cytosol]
precedingEvent	[Reaction:R-RNO-4608854] SMURF1/2 are recruited to the DVL2:PARD6A complex - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-4608852
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-4608870] Asymmetric localization of PCP proteins
(precedingEvent)	[BlackBoxEvent:R-RNO-4608855] PRICKLE1 is degraded by the proteasome
(inferredTo)	[Reaction:R-HSA-4608852] SMURF1/2 ubiquitinates PRICKLE1

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