Reactome | Proteasome-dependent degradation of ubiquitinated CDH1

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Proteasome-dependent degradation of ubiquitinated CDH1 Show undefined attributes

catalystActivity	[CatalystActivity:10103487] endopeptidase activity of 26S proteasome [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:171062] early endosome membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10215491
displayName	Proteasome-dependent degradation of ubiquitinated CDH1
eventOf	[Pathway:R-RNO-9766229] Degradation of CDH1 - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-9766223] Proteasome-dependent degradation of ubiquitinated CDH1 - Homo sapiens
input	[Complex:R-RNO-9934666] PolyUbK48-CDH1:MDM2 [early endosome membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Proteasome-dependent degradation of ubiquitinated CDH1
output	[EntityWithAccessionedSequence:R-RNO-198644] MDM2 [cytosol] [DefinedSet:R-RNO-113595] Ub [cytosol]
precedingEvent	[BlackBoxEvent:R-RNO-9934584] The complex of MDM2 and CDH1 translocates to early endosomes - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9766223
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-9766229] Degradation of CDH1
(inferredTo)	[BlackBoxEvent:R-HSA-9766223] Proteasome-dependent degradation of ubiquitinated CDH1

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