Reactome | Ubiquitination of stimulated EGFR (CBL:GRB2)

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Ubiquitination of stimulated EGFR (CBL:GRB2) Show undefined attributes

catalystActivity	[CatalystActivity:10120630] ubiquitin protein ligase activity of EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10120632
displayName	Ubiquitination of stimulated EGFR (CBL:GRB2)
eventOf	[Pathway:R-RNO-182971] EGFR downregulation - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-183036] Ubiquitination of stimulated EGFR (CBL:GRB2) - Homo sapiens
input	[Complex:R-RNO-182948] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] 2 × [DefinedSet:R-RNO-113595] Ub [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Ubiquitination of stimulated EGFR (CBL:GRB2)
output	[Complex:R-RNO-182945] EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane]
precedingEvent	[Reaction:R-RNO-183058] Phosphorylation of CBL (EGFR:GRB2:CBL) - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-183036
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-182971] EGFR downregulation
(inferredTo)	[Reaction:R-HSA-183036] Ubiquitination of stimulated EGFR (CBL:GRB2)

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