Reactome | SCF-beta-TrCP ubiquitinylates IkB

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SCF-beta-TrCP ubiquitinylates IkB Show undefined attributes

category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10151217
displayName	SCF-beta-TrCP ubiquitinylates IkB
eventOf	[Pathway:R-RNO-1169091] Activation of NF-kappaB in B cells - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-RNO-1168640] Ubiquitinated IkB is degraded - Rattus norvegicus
inferredFrom	[BlackBoxEvent:R-HSA-1168643] SCF-beta-TrCP ubiquitinylates IkB - Homo sapiens
input	[Complex:R-RNO-1168617] NF-kappaB:p-IkB:SCF-betaTrCP [cytosol] [DefinedSet:R-RNO-113595] Ub [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	SCF-beta-TrCP ubiquitinylates IkB
output	[DefinedSet:R-RNO-1168601] (BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] [DefinedSet:R-RNO-1168613] NF-kappaB p50,p65,c-Rel:ub-p-IKB [cytosol]
precedingEvent	[Reaction:R-RNO-1168642] SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48895] Rattus norvegicus
stId	R-RNO-1168643
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-1169091] Activation of NF-kappaB in B cells
(precedingEvent)	[BlackBoxEvent:R-RNO-1168640] Ubiquitinated IkB is degraded
(inferredTo)	[BlackBoxEvent:R-HSA-1168643] SCF-beta-TrCP ubiquitinylates IkB

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