Reactome | 3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105

Schema > BlackBoxEvent > Entries

3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 Show undefined attributes

category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10183691
displayName	3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105
eventOf	[Pathway:R-RNO-5684264] MAP3K8 (TPL2)-dependent MAPK1/3 activation - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-5684273] 3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 - Homo sapiens
input	[Complex:R-RNO-5684242] 3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105
output	[EntityWithAccessionedSequence:R-RNO-5684259] phospho-p-S400,T290-MAP3K8 [cytosol] [EntityWithAccessionedSequence:R-RNO-451661] Tnip2 [cytosol] 9 × [DefinedSet:R-RNO-113595] Ub [cytosol]
precedingEvent	[Reaction:R-RNO-5684250] SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5684273
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-5684264] MAP3K8 (TPL2)-dependent MAPK1/3 activation
(inferredTo)	[BlackBoxEvent:R-HSA-5684273] 3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105

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