Reactome | STING ubiquitination by TRIM32 or TRIM56

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STING ubiquitination by TRIM32 or TRIM56 Show undefined attributes

catalystActivity	[CatalystActivity:10169135] ubiquitin-protein transferase activity of STING:TRIM32/TRIM56 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10169137
displayName	STING ubiquitination by TRIM32 or TRIM56
eventOf	[Pathway:R-RNO-3134975] Regulation of innate immune responses to cytosolic DNA - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-3134800] STING dimerization - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-3134804] STING ubiquitination by TRIM32 or TRIM56 - Homo sapiens
input	[Complex:R-RNO-1834963] STING:TRIM32/TRIM56 [endoplasmic reticulum membrane] 3 × [DefinedSet:R-RNO-113595] Ub [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	STING ubiquitination by TRIM32 or TRIM56
output	[EntityWithAccessionedSequence:R-RNO-3134805] K63polyUb-STING [endoplasmic reticulum membrane] [EntityWithAccessionedSequence:R-RNO-976030] Trim32 [cytosol]
precedingEvent	[Reaction:R-RNO-1964496] STING binds TRIM32 or TRIM56 - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-3134804
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-3134975] Regulation of innate immune responses to cytosolic DNA
(precedingEvent)	[Reaction:R-RNO-3134800] STING dimerization
(inferredTo)	[Reaction:R-HSA-3134804] STING ubiquitination by TRIM32 or TRIM56

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