Reactome | TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4

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TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 Show undefined attributes

category	omitted
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10176869
displayName	TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4
eventOf	[Pathway:R-RNO-936964] Activation of IRF3, IRF7 mediated by TBK1, IKK? (IKBKE) - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-9823932] Recruitment of IKK? (IKBKE) to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 - Rattus norvegicus [Reaction:R-RNO-9823910] Recruitment of TBK1 to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 - Rattus norvegicus
inferredFrom	[BlackBoxEvent:R-HSA-5362500] TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 - Homo sapiens
input	[Complex:R-RNO-5362479] TANK:K63-poly-Ub-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] [DefinedSet:R-RNO-113595] Ub [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4
output	[Complex:R-RNO-5362507] K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5362500
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-936964] Activation of IRF3, IRF7 mediated by TBK1, IKK? (IKBKE)
(precedingEvent)	[Reaction:R-RNO-9823932] Recruitment of IKK? (IKBKE) to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 [Reaction:R-RNO-9823910] Recruitment of TBK1 to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4
(inferredTo)	[BlackBoxEvent:R-HSA-5362500] TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4

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