Reactome | CBL ubiquitinates FRS2 and FGFR3

Schema > Reaction > Entries

CBL ubiquitinates FRS2 and FGFR3 Show undefined attributes

catalystActivity	[CatalystActivity:10181072] ubiquitin protein ligase activity of Activated FGFR3:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10181074
displayName	CBL ubiquitinates FRS2 and FGFR3
eventOf	[Pathway:R-RNO-5654732] Negative regulation of FGFR3 signaling - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5654679] CBL ubiquitinates FRS2 and FGFR3 - Homo sapiens
input	[Complex:R-RNO-5654307] Activated FGFR3:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] [DefinedSet:R-RNO-113595] Ub [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CBL ubiquitinates FRS2 and FGFR3
output	[Complex:R-RNO-5654362] Ub-Activated FGFR3 complex:Ub-p-FRS2 [plasma membrane]
precedingEvent	[Reaction:R-RNO-5654730] p-CBL:GRB2 binds p-FRS2:activated FGFR3 - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5654679
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-5654732] Negative regulation of FGFR3 signaling
(inferredTo)	[Reaction:R-HSA-5654679] CBL ubiquitinates FRS2 and FGFR3