Reactome | CBL-mediated ubiquitination of CIN85

Schema > Reaction > Entries

CBL-mediated ubiquitination of CIN85 Show undefined attributes

catalystActivity	[CatalystActivity:10120568] ubiquitin-protein transferase activity of EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10120570
displayName	CBL-mediated ubiquitination of CIN85
eventOf	[Pathway:R-RNO-182971] EGFR downregulation - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-182986] CBL-mediated ubiquitination of CIN85 - Homo sapiens
input	[Complex:R-RNO-182961] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] [DefinedSet:R-RNO-113595] Ub [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CBL-mediated ubiquitination of CIN85
output	[Complex:R-RNO-182936] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:Ub-CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane]
precedingEvent	[Reaction:R-RNO-183072] EGFR non-clathrin mediated endocytosis - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-182986
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-182971] EGFR downregulation
(inferredTo)	[Reaction:R-HSA-182986] CBL-mediated ubiquitination of CIN85