Reactome | CTLH E3 ligase ubiquitinates PKM-1

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CTLH E3 ligase ubiquitinates PKM-1 Show undefined attributes

catalystActivity	[CatalystActivity:10219096] ubiquitin-protein transferase activity of CTLH E3 ligase [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10219111
displayName	CTLH E3 ligase ubiquitinates PKM-1
eventOf	[Pathway:R-RNO-9861718] Regulation of pyruvate metabolism - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-9861640] CTLH E3 ligase ubiquitinates PKM-1 - Homo sapiens
input	[EntityWithAccessionedSequence:R-RNO-71667] Pkml1 [cytosol] [DefinedSet:R-RNO-113595] Ub [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CTLH E3 ligase ubiquitinates PKM-1
output	[EntityWithAccessionedSequence:R-RNO-9861692] Pkml1 [cytosol]
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9861640
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-9861718] Regulation of pyruvate metabolism
(inferredTo)	[BlackBoxEvent:R-HSA-9861640] CTLH E3 ligase ubiquitinates PKM-1

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