Reactome | ERBB4 ubiquitination by WWP1/ITCH

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ERBB4 ubiquitination by WWP1/ITCH Show undefined attributes

catalystActivity	[CatalystActivity:10152435] ubiquitin-protein transferase activity of ERBB4/m80/s80:WWP1/ITCH [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10152437
displayName	ERBB4 ubiquitination by WWP1/ITCH
eventOf	[Pathway:R-RNO-1253288] Downregulation of ERBB4 signaling - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-1253282] ERBB4 ubiquitination by WWP1/ITCH - Homo sapiens
input	[Complex:R-RNO-1253284] ERBB4/m80/s80:WWP1/ITCH [plasma membrane] [DefinedSet:R-RNO-113595] Ub [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ERBB4 ubiquitination by WWP1/ITCH
output	[Complex:R-RNO-1253293] Ub-ERBB4:WWP1/ITCH [plasma membrane]
precedingEvent	[Reaction:R-RNO-1253300] ERBB4 binds WWP1/ITCH ubiquitin ligases - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-1253282
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-1253288] Downregulation of ERBB4 signaling
(inferredTo)	[Reaction:R-HSA-1253282] ERBB4 ubiquitination by WWP1/ITCH

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