Reactome | DVL1 is ubiquitinated by HECW1

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DVL1 is ubiquitinated by HECW1 Show undefined attributes

catalystActivity	[CatalystActivity:10173568] ubiquitin protein ligase activity of DVL1:HECW1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10173570
displayName	DVL1 is ubiquitinated by HECW1
eventOf	[Pathway:R-RNO-4641258] Degradation of DVL - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-RNO-4641260] Ubiquitinated DVL1 is degraded by the proteasome - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-4641159] DVL1 is ubiquitinated by HECW1 - Homo sapiens
input	[Complex:R-RNO-4641154] DVL1:HECW1 [cytosol] [DefinedSet:R-RNO-113595] Ub [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	DVL1 is ubiquitinated by HECW1
output	[Complex:R-RNO-4641160] ub-DVL1:HECW1 [cytosol]
precedingEvent	[Reaction:R-RNO-4641155] DVL1 is bound by the HECT ubiquitin ligase HECW1 - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-4641159
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-4641258] Degradation of DVL
(precedingEvent)	[BlackBoxEvent:R-RNO-4641260] Ubiquitinated DVL1 is degraded by the proteasome
(inferredTo)	[Reaction:R-HSA-4641159] DVL1 is ubiquitinated by HECW1

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