Reactome | SCF(beta-TrCP) ubiquitinates p-GLI3

Schema > Reaction > Entries

SCF(beta-TrCP) ubiquitinates p-GLI3 Show undefined attributes

catalystActivity	[CatalystActivity:10127467] ubiquitin-protein transferase activity of BTRC:CUL1:RBX1:SKP1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10178330
displayName	SCF(beta-TrCP) ubiquitinates p-GLI3
eventOf	[Pathway:R-RNO-5610785] GLI3 is processed to GLI3R by the proteasome - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-RNO-5610754] GLI3 is partially degraded by the proteasome to yield the GLI3 repressor - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-5610746] SCF(beta-TrCP) ubiquitinates p-GLI3 - Homo sapiens
input	[Complex:R-RNO-5610587] p13S-GLI3:SUFU [ciliary base] [DefinedSet:R-RNO-113595] Ub [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	SCF(beta-TrCP) ubiquitinates p-GLI3
output	[Complex:R-RNO-5610526] 4xub-p13S-Gli3:SUFU [ciliary base]
precedingEvent	[Reaction:R-RNO-5610732] GSK3 phosphorylates p-GLI3 - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5610746
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-5610785] GLI3 is processed to GLI3R by the proteasome
(precedingEvent)	[BlackBoxEvent:R-RNO-5610754] GLI3 is partially degraded by the proteasome to yield the GLI3 repressor
(inferredTo)	[Reaction:R-HSA-5610746] SCF(beta-TrCP) ubiquitinates p-GLI3

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