Reactome | CHIP (STUB1) mediates ubiquitination of ERBB2

Schema > Reaction > Entries

CHIP (STUB1) mediates ubiquitination of ERBB2 Show undefined attributes

catalystActivity	[CatalystActivity:10159345] ubiquitin-protein transferase activity of STUB1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10159347
displayName	CHIP (STUB1) mediates ubiquitination of ERBB2
eventOf	[Pathway:R-RNO-8863795] Downregulation of ERBB2 signaling - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-1918092] CHIP (STUB1) mediates ubiquitination of ERBB2 - Homo sapiens
input	[Complex:R-RNO-1227970] ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] 2 × [DefinedSet:R-RNO-113595] Ub [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CHIP (STUB1) mediates ubiquitination of ERBB2
output	[Complex:R-RNO-1918083] Ub-ERBB2:ERBIN:Ub-HSP90:CDC37 [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-1918092
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-8863795] Downregulation of ERBB2 signaling
(inferredTo)	[Reaction:R-HSA-1918092] CHIP (STUB1) mediates ubiquitination of ERBB2

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