Reactome | TRAF2,6 ubiquitinates NLRC5

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TRAF2,6 ubiquitinates NLRC5 Show undefined attributes

catalystActivity	[CatalystActivity:10214946] ubiquitin-protein transferase activity of TRAF2, TRAF6 [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10214948
displayName	TRAF2,6 ubiquitinates NLRC5
eventOf	[Pathway:R-RNO-9758274] Regulation of NF-kappa B signaling - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-RNO-9750942] USP14 deubiquitinates NLRC5 - Rattus norvegicus
inferredFrom	[BlackBoxEvent:R-HSA-9750946] TRAF2,6 ubiquitinates NLRC5 - Homo sapiens
input	[Complex:R-RNO-9750228] CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] 3 × [DefinedSet:R-RNO-113595] Ub [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	TRAF2,6 ubiquitinates NLRC5
output	[EntityWithAccessionedSequence:R-RNO-168104] Chuk [cytosol] [EntityWithAccessionedSequence:R-RNO-168114] IKBKB [cytosol] [EntityWithAccessionedSequence:R-RNO-9750938] Nlrc5 [cytosol]
precedingEvent	[Reaction:R-RNO-9750226] NLRC5 binds IKBKB and CHUK - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9750946
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-9758274] Regulation of NF-kappa B signaling
(precedingEvent)	[BlackBoxEvent:R-RNO-9750942] USP14 deubiquitinates NLRC5
(inferredTo)	[BlackBoxEvent:R-HSA-9750946] TRAF2,6 ubiquitinates NLRC5

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