Reactome | PIP3 activates AKT signaling

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PIP3 activates AKT signaling Show undefined attributes

created	[InstanceEdit:1257605] Orlic-Milacic, Marija, 2011-05-02
dbId	1257604
diseasePathways	[Pathway:R-HSA-2219528] PI3K/AKT Signaling in Cancer - Homo sapiens [Pathway:R-HSA-2219530] Constitutive Signaling by Aberrant PI3K in Cancer - Homo sapiens [Pathway:R-HSA-5674400] Constitutive Signaling by AKT1 E17K in Cancer - Homo sapiens [Pathway:R-HSA-5674404] PTEN Loss of Function in Cancer - Homo sapiens
displayName	PIP3 activates AKT signaling
eventOf	[Pathway:R-HSA-9006925] Intracellular signaling by second messengers - Homo sapiens
figure	[Figure:2127641] /figures/Pathway_Illustrations/PIP3AKT_72_oicr.png
goBiologicalProcess	[GO_BiologicalProcess:262292] positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-114542] RAC1,RAC2,RHOG activate PI3K - Homo sapiens [Reaction:R-HSA-2316434] PI3K phosphorylates PIP2 to PIP3 - Homo sapiens [Reaction:R-HSA-2317332] PIP3 recruits AKT to the membrane - Homo sapiens [Reaction:R-HSA-2316429] PIP3 recruits PDPK1 to the membrane - Homo sapiens [Reaction:R-HSA-198640] mTORC2 phosphorylates AKT at S473 - Homo sapiens [Reaction:R-HSA-6795290] mTORC2 phosphorylates SGK1 - Homo sapiens [Reaction:R-HSA-2317314] AKT binds PDPK1 - Homo sapiens [Reaction:R-HSA-198270] PDPK1 phosphorylates AKT at T308 - Homo sapiens [Reaction:R-HSA-6795473] PDPK1 phosphorylates SGK1 - Homo sapiens [Pathway:R-HSA-198323] AKT phosphorylates targets in the cytosol - Homo sapiens [Reaction:R-HSA-198298] AKT translocates to the nucleus - Homo sapiens [Pathway:R-HSA-198693] AKT phosphorylates targets in the nucleus - Homo sapiens [Pathway:R-HSA-199418] Negative regulation of the PI3K/AKT network - Homo sapiens [Reaction:R-HSA-2219524] PDPK1 binds PIP2 - Homo sapiens [Pathway:R-HSA-6807070] PTEN Regulation - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2023-06-07
maxDepth	5
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	PIP3 activates AKT signaling PI3K/AKT Signaling
orthologousEvent	[Pathway:R-MMU-1257604] PIP3 activates AKT signaling - Mus musculus [Pathway:R-RNO-1257604] PIP3 activates AKT signaling - Rattus norvegicus [Pathway:R-PFA-1257604] PIP3 activates AKT signaling - Plasmodium falciparum [Pathway:R-SCE-1257604] PIP3 activates AKT signaling - Saccharomyces cerevisiae [Pathway:R-SPO-1257604] PIP3 activates AKT signaling - Schizosaccharomyces pombe [Pathway:R-DDI-1257604] PIP3 activates AKT signaling - Dictyostelium discoideum [Pathway:R-CEL-1257604] PIP3 activates AKT signaling - Caenorhabditis elegans [Pathway:R-DME-1257604] PIP3 activates AKT signaling - Drosophila melanogaster [Pathway:R-GGA-1257604] PIP3 activates AKT signaling - Gallus gallus [Pathway:R-XTR-1257604] PIP3 activates AKT signaling - Xenopus tropicalis [Pathway:R-SSC-1257604] PIP3 activates AKT signaling - Sus scrofa [Pathway:R-DRE-1257604] PIP3 activates AKT signaling - Danio rerio [Pathway:R-BTA-1257604] PIP3 activates AKT signaling - Bos taurus [Pathway:R-CFA-1257604] PIP3 activates AKT signaling - Canis familiaris
precedingEvent	[BlackBoxEvent:R-HSA-198266] PI3K produces PIP3 and other phosphatidyl inositides - Homo sapiens
previousReviewStatus	[ReviewStatus:9821382] five stars
releaseDate	2011-06-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37 [InstanceEdit:2463860] Thorpe, Lauren, 2012-08-13 [InstanceEdit:2463859] Yuzugullu, Haluk, 2012-08-13 [InstanceEdit:2463854] Zhao, Jean J, 2012-08-13
revised	[InstanceEdit:2327847] Orlic-Milacic, M, 2012-06-21
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-1257604
summation	[Summation:1549530] Signaling by AKT is one of the key outcomes of receptor tyro...
updateTrackers	[UpdateTracker:9784260] Update Tracker - [Pathway:1257604] PIP3 activates AKT signaling - v54:[updateContainedRLE] [UpdateTracker:9783662] Update Tracker - [Pathway:1257604] PIP3 activates AKT signaling - v56:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9781150] Update Tracker - [Pathway:1257604] PIP3 activates AKT signaling - v61:[addHasEvent, updateContainedPathway, updateContainedRLE] [UpdateTracker:9835705] Update Tracker - [Pathway:1257604] PIP3 activates AKT signaling - v85:[addHasEvent] [UpdateTracker:9782796] Update Tracker - [Pathway:1257604] PIP3 activates AKT signaling - v58:[addHasEvent, updateIndirectRLE] [UpdateTracker:9782458] Update Tracker - [Pathway:1257604] PIP3 activates AKT signaling - v59:[updateContainedRLE, updateIndirectRLE] [UpdateTracker:9789275] Update Tracker - [Pathway:1257604] PIP3 activates AKT signaling - v38:[addSummation, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9779223] Update Tracker - [Pathway:1257604] PIP3 activates AKT signaling - v66:[addHasEvent, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9785323] Update Tracker - [Pathway:1257604] PIP3 activates AKT signaling - v52:[updateIndirectRLE] [UpdateTracker:9787672] Update Tracker - [Pathway:1257604] PIP3 activates AKT signaling - v44:[updateIndirectRLE] [UpdateTracker:9788336] Update Tracker - [Pathway:1257604] PIP3 activates AKT signaling - v42:[add_removeHasEvent, modifyText, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9783235] Update Tracker - [Pathway:1257604] PIP3 activates AKT signaling - v57:[updateIndirectRLE] [UpdateTracker:9778759] Update Tracker - [Pathway:1257604] PIP3 activates AKT signaling - v67:[updateIndirectRLE] [UpdateTracker:9780455] Update Tracker - [Pathway:1257604] PIP3 activates AKT signaling - v63:[removeHasEvent] [UpdateTracker:9784040] Update Tracker - [Pathway:1257604] PIP3 activates AKT signaling - v55:[updateContainedRLE, updateIndirectRLE] [UpdateTracker:9775050] Update Tracker - [Pathway:1257604] PIP3 activates AKT signaling - v80:[updateContainedRLE, updateIndirectRLE]

Referrals

(hasEvent)	[Pathway:R-HSA-9006925] Intracellular signaling by second messengers
(hasEncapsulatedEvent)	[Pathway:R-HSA-5687128] MAPK6/MAPK4 signaling [Pathway:R-HSA-1483255] PI Metabolism [Pathway:R-HSA-201556] Signaling by ALK [Pathway:R-HSA-9842663] Signaling by LTK [Pathway:R-HSA-9607240] FLT3 Signaling [Pathway:R-HSA-114604] GPVI-mediated activation cascade [Pathway:R-HSA-453279] Mitotic G1 phase and G1/S transition [Pathway:R-HSA-9705683] SARS-CoV-2-host interactions [Pathway:R-HSA-109606] Intrinsic Pathway for Apoptosis [Pathway:R-HSA-1227986] Signaling by ERBB2 [Pathway:R-HSA-8848021] Signaling by PTK6 [Pathway:R-HSA-9614085] FOXO-mediated transcription [Pathway:R-HSA-6807070] PTEN Regulation [Pathway:R-HSA-5654738] Signaling by FGFR2 [Pathway:R-HSA-202403] TCR signaling [Pathway:R-HSA-5654741] Signaling by FGFR3 [Pathway:R-HSA-5654736] Signaling by FGFR1 [Pathway:R-HSA-983705] Signaling by the B Cell Receptor (BCR) [Pathway:R-HSA-389356] Co-stimulation by CD28 [Pathway:R-HSA-5654743] Signaling by FGFR4 [Pathway:R-HSA-165159] MTOR signalling [Pathway:R-HSA-5628897] TP53 Regulates Metabolic Genes [Pathway:R-HSA-9034015] Signaling by NTRK3 (TRKC) [Pathway:R-HSA-9006115] Signaling by NTRK2 (TRKB) [Pathway:R-HSA-9927354] Co-stimulation by ICOS [Pathway:R-HSA-202131] Metabolism of nitric oxide: NOS3 activation and regulation [Pathway:R-HSA-2454202] Fc epsilon receptor (FCERI) signaling [Pathway:R-HSA-2172127] DAP12 interactions [Pathway:R-HSA-5625740] RHO GTPases activate PKNs [Pathway:R-HSA-177929] Signaling by EGFR [Pathway:R-HSA-9009391] Extra-nuclear estrogen signaling [Pathway:R-HSA-8983432] Interleukin-15 signaling [Pathway:R-HSA-186797] Signaling by PDGF [Pathway:R-HSA-1433557] Signaling by SCF-KIT [Pathway:R-HSA-1236394] Signaling by ERBB4 [Pathway:R-HSA-6806003] Regulation of TP53 Expression and Degradation [Pathway:R-HSA-6806834] Signaling by MET [Pathway:R-HSA-187037] Signaling by NTRK1 (TRKA)
(normalPathway)	[Pathway:R-HSA-2219528] PI3K/AKT Signaling in Cancer [Pathway:R-HSA-2219530] Constitutive Signaling by Aberrant PI3K in Cancer [Pathway:R-HSA-5674400] Constitutive Signaling by AKT1 E17K in Cancer [Pathway:R-HSA-5674404] PTEN Loss of Function in Cancer
(updatedInstance)	[UpdateTracker:9784260] Update Tracker - [Pathway:1257604] PIP3 activates AKT signaling - v54:[updateContainedRLE] [UpdateTracker:9783662] Update Tracker - [Pathway:1257604] PIP3 activates AKT signaling - v56:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9781150] Update Tracker - [Pathway:1257604] PIP3 activates AKT signaling - v61:[addHasEvent, updateContainedPathway, updateContainedRLE] [UpdateTracker:9835705] Update Tracker - [Pathway:1257604] PIP3 activates AKT signaling - v85:[addHasEvent] [UpdateTracker:9782796] Update Tracker - [Pathway:1257604] PIP3 activates AKT signaling - v58:[addHasEvent, updateIndirectRLE] [UpdateTracker:9782458] Update Tracker - [Pathway:1257604] PIP3 activates AKT signaling - v59:[updateContainedRLE, updateIndirectRLE] [UpdateTracker:9789275] Update Tracker - [Pathway:1257604] PIP3 activates AKT signaling - v38:[addSummation, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9779223] Update Tracker - [Pathway:1257604] PIP3 activates AKT signaling - v66:[addHasEvent, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9785323] Update Tracker - [Pathway:1257604] PIP3 activates AKT signaling - v52:[updateIndirectRLE] [UpdateTracker:9787672] Update Tracker - [Pathway:1257604] PIP3 activates AKT signaling - v44:[updateIndirectRLE] [UpdateTracker:9788336] Update Tracker - [Pathway:1257604] PIP3 activates AKT signaling - v42:[add_removeHasEvent, modifyText, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9783235] Update Tracker - [Pathway:1257604] PIP3 activates AKT signaling - v57:[updateIndirectRLE] [UpdateTracker:9778759] Update Tracker - [Pathway:1257604] PIP3 activates AKT signaling - v67:[updateIndirectRLE] [UpdateTracker:9780455] Update Tracker - [Pathway:1257604] PIP3 activates AKT signaling - v63:[removeHasEvent] [UpdateTracker:9784040] Update Tracker - [Pathway:1257604] PIP3 activates AKT signaling - v55:[updateContainedRLE, updateIndirectRLE] [UpdateTracker:9775050] Update Tracker - [Pathway:1257604] PIP3 activates AKT signaling - v80:[updateContainedRLE, updateIndirectRLE]

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