Reactome | Fc epsilon receptor (FCERI) signaling

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Fc epsilon receptor (FCERI) signaling Show undefined attributes

authored	[InstanceEdit:2871799] Niarakis, Anna, 2012-12-21
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:2454233] Garapati, P V, 2012-08-22
crossReference	[DatabaseIdentifier:12819451] BioModels Database:BIOMD0000000477
dbId	2454202
displayName	Fc epsilon receptor (FCERI) signaling
doi	10.3180/R-HSA-2454202.2
edited	[InstanceEdit:2454233] Garapati, P V, 2012-08-22
eventOf	[Pathway:R-HSA-168249] Innate Immune System - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:2132801] Fc-epsilon receptor signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-9725206] IgE binds FCERI - Homo sapiens [Reaction:R-HSA-9724685] IgE binds omalizumab - Homo sapiens [BlackBoxEvent:R-HSA-2454192] Allergen dependent IgE bound FCERI aggregation - Homo sapiens [Reaction:R-HSA-2730862] Autophosphorylation of LYN kinase - Homo sapiens [Reaction:R-HSA-2454208] Phosphorylation of beta and gamma subunits by LYN - Homo sapiens [Reaction:R-HSA-2454240] Recruitment of SYK to p-FCERI gamma subunit - Homo sapiens [Reaction:R-HSA-2454239] Phosphorylation of SYK - Homo sapiens [Reaction:R-HSA-2730843] Phosphorylation of LAT by p-SYK - Homo sapiens [Pathway:R-HSA-2871796] FCERI mediated MAPK activation - Homo sapiens [Pathway:R-HSA-2871809] FCERI mediated Ca+2 mobilization - Homo sapiens [Pathway:R-HSA-2871837] FCERI mediated NF-kB activation - Homo sapiens [Pathway:R-HSA-2730905] Role of LAT2/NTAL/LAB on calcium mobilization - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2023-03-29
literatureReference	[LiteratureReference:2454179] The ins and outs of IgE-dependent mast-cell exocytosis [LiteratureReference:2871788] Immunoglobulin E receptor signaling and asthma
maxDepth	3
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Fc epsilon receptor (FCERI) signaling
orthologousEvent	[Pathway:R-MMU-2454202] Fc epsilon receptor (FCERI) signaling - Mus musculus [Pathway:R-RNO-2454202] Fc epsilon receptor (FCERI) signaling - Rattus norvegicus [Pathway:R-CFA-2454202] Fc epsilon receptor (FCERI) signaling - Canis familiaris [Pathway:R-BTA-2454202] Fc epsilon receptor (FCERI) signaling - Bos taurus [Pathway:R-SSC-2454202] Fc epsilon receptor (FCERI) signaling - Sus scrofa [Pathway:R-DRE-2454202] Fc epsilon receptor (FCERI) signaling - Danio rerio [Pathway:R-XTR-2454202] Fc epsilon receptor (FCERI) signaling - Xenopus tropicalis [Pathway:R-GGA-2454202] Fc epsilon receptor (FCERI) signaling - Gallus gallus [Pathway:R-DME-2454202] Fc epsilon receptor (FCERI) signaling - Drosophila melanogaster [Pathway:R-CEL-2454202] Fc epsilon receptor (FCERI) signaling - Caenorhabditis elegans [Pathway:R-DDI-2454202] Fc epsilon receptor (FCERI) signaling - Dictyostelium discoideum [Pathway:R-SPO-2454202] Fc epsilon receptor (FCERI) signaling - Schizosaccharomyces pombe [Pathway:R-PFA-2454202] Fc epsilon receptor (FCERI) signaling - Plasmodium falciparum [Pathway:R-SCE-2454202] Fc epsilon receptor (FCERI) signaling - Saccharomyces cerevisiae
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3139040] Roncagalli, Romain, 2013-02-13
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-2454202
summation	[Summation:2871819] Mast cells (MC) are distributed in tissues throughout the hu...
updateTrackers	[UpdateTracker:9776199] Update Tracker - [Pathway:2454202] Fc epsilon receptor (FCERI) signaling - v77:[addHasEvent] [UpdateTracker:9780284] Update Tracker - [Pathway:2454202] Fc epsilon receptor (FCERI) signaling - v63:[updateIndirectRLE] [UpdateTracker:9786550] Update Tracker - [Pathway:2454202] Fc epsilon receptor (FCERI) signaling - v49:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9782915] Update Tracker - [Pathway:2454202] Fc epsilon receptor (FCERI) signaling - v58:[updateContainedPathway] [UpdateTracker:9778692] Update Tracker - [Pathway:2454202] Fc epsilon receptor (FCERI) signaling - v67:[updateIndirectRLE] [UpdateTracker:9787014] Update Tracker - [Pathway:2454202] Fc epsilon receptor (FCERI) signaling - v46:[updateContainedPathway] [UpdateTracker:9774922] Update Tracker - [Pathway:2454202] Fc epsilon receptor (FCERI) signaling - v80:[updateIndirectRLE] [UpdateTracker:9786076] Update Tracker - [Pathway:2454202] Fc epsilon receptor (FCERI) signaling - v50:[updateIndirectRLE] [UpdateTracker:9784747] Update Tracker - [Pathway:2454202] Fc epsilon receptor (FCERI) signaling - v53:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9780877] Update Tracker - [Pathway:2454202] Fc epsilon receptor (FCERI) signaling - v62:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9781918] Update Tracker - [Pathway:2454202] Fc epsilon receptor (FCERI) signaling - v60:[updateIndirectRLE] [UpdateTracker:9783487] Update Tracker - [Pathway:2454202] Fc epsilon receptor (FCERI) signaling - v56:[updateContainedPathway] [UpdateTracker:9776336] Update Tracker - [Pathway:2454202] Fc epsilon receptor (FCERI) signaling - v76:[updateIndirectRLE] [UpdateTracker:9846786] Update Tracker - [Pathway:2454202] Fc epsilon receptor (FCERI) signaling - v84:[updateContainedRLE] [UpdateTracker:9782632] Update Tracker - [Pathway:2454202] Fc epsilon receptor (FCERI) signaling - v59:[updateIndirectRLE] [UpdateTracker:9783052] Update Tracker - [Pathway:2454202] Fc epsilon receptor (FCERI) signaling - v57:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9785131] Update Tracker - [Pathway:2454202] Fc epsilon receptor (FCERI) signaling - v52:[updateIndirectRLE] [UpdateTracker:9781133] Update Tracker - [Pathway:2454202] Fc epsilon receptor (FCERI) signaling - v61:[updateContainedPathway]

Referrals

(hasEvent)	[Pathway:R-HSA-168249] Innate Immune System
(hasEncapsulatedEvent)	[Pathway:R-HSA-5673001] RAF/MAP kinase cascade
(updatedInstance)	[UpdateTracker:9776199] Update Tracker - [Pathway:2454202] Fc epsilon receptor (FCERI) signaling - v77:[addHasEvent] [UpdateTracker:9780284] Update Tracker - [Pathway:2454202] Fc epsilon receptor (FCERI) signaling - v63:[updateIndirectRLE] [UpdateTracker:9786550] Update Tracker - [Pathway:2454202] Fc epsilon receptor (FCERI) signaling - v49:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9782915] Update Tracker - [Pathway:2454202] Fc epsilon receptor (FCERI) signaling - v58:[updateContainedPathway] [UpdateTracker:9778692] Update Tracker - [Pathway:2454202] Fc epsilon receptor (FCERI) signaling - v67:[updateIndirectRLE] [UpdateTracker:9787014] Update Tracker - [Pathway:2454202] Fc epsilon receptor (FCERI) signaling - v46:[updateContainedPathway] [UpdateTracker:9774922] Update Tracker - [Pathway:2454202] Fc epsilon receptor (FCERI) signaling - v80:[updateIndirectRLE] [UpdateTracker:9786076] Update Tracker - [Pathway:2454202] Fc epsilon receptor (FCERI) signaling - v50:[updateIndirectRLE] [UpdateTracker:9784747] Update Tracker - [Pathway:2454202] Fc epsilon receptor (FCERI) signaling - v53:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9780877] Update Tracker - [Pathway:2454202] Fc epsilon receptor (FCERI) signaling - v62:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9781918] Update Tracker - [Pathway:2454202] Fc epsilon receptor (FCERI) signaling - v60:[updateIndirectRLE] [UpdateTracker:9783487] Update Tracker - [Pathway:2454202] Fc epsilon receptor (FCERI) signaling - v56:[updateContainedPathway] [UpdateTracker:9776336] Update Tracker - [Pathway:2454202] Fc epsilon receptor (FCERI) signaling - v76:[updateIndirectRLE] [UpdateTracker:9846786] Update Tracker - [Pathway:2454202] Fc epsilon receptor (FCERI) signaling - v84:[updateContainedRLE] [UpdateTracker:9782632] Update Tracker - [Pathway:2454202] Fc epsilon receptor (FCERI) signaling - v59:[updateIndirectRLE] [UpdateTracker:9783052] Update Tracker - [Pathway:2454202] Fc epsilon receptor (FCERI) signaling - v57:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9785131] Update Tracker - [Pathway:2454202] Fc epsilon receptor (FCERI) signaling - v52:[updateIndirectRLE] [UpdateTracker:9781133] Update Tracker - [Pathway:2454202] Fc epsilon receptor (FCERI) signaling - v61:[updateContainedPathway]

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