Reactome | PIP3 activates AKT signaling

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PIP3 activates AKT signaling Show undefined attributes

created	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
dbId	11128826
displayName	PIP3 activates AKT signaling
eventOf	[Pathway:R-PFA-9006925] Intracellular signaling by second messengers - Plasmodium falciparum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:262292] positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-PFA-2316429] PIP3 recruits PDPK1 to the membrane - Plasmodium falciparum [Pathway:R-PFA-199418] Negative regulation of the PI3K/AKT network - Plasmodium falciparum [Reaction:R-PFA-2219524] PDPK1 binds PIP2 - Plasmodium falciparum [Pathway:R-PFA-6807070] PTEN Regulation - Plasmodium falciparum
inferredFrom	[Pathway:R-HSA-1257604] PIP3 activates AKT signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	4
name	PIP3 activates AKT signaling PI3K/AKT Signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:170928] Plasmodium falciparum
stId	R-PFA-1257604
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEncapsulatedEvent)	[Pathway:R-PFA-5687128] MAPK6/MAPK4 signaling [Pathway:R-PFA-1483255] PI Metabolism [Pathway:R-PFA-114604] GPVI-mediated activation cascade [Pathway:R-PFA-187037] Signaling by NTRK1 (TRKA) [Pathway:R-PFA-5628897] TP53 Regulates Metabolic Genes [Pathway:R-PFA-8848021] Signaling by PTK6 [Pathway:R-PFA-453279] Mitotic G1 phase and G1/S transition [Pathway:R-PFA-109606] Intrinsic Pathway for Apoptosis [Pathway:R-PFA-2454202] Fc epsilon receptor (FCERI) signaling [Pathway:R-PFA-202131] Metabolism of nitric oxide: NOS3 activation and regulation [Pathway:R-PFA-389356] Co-stimulation by CD28 [Pathway:R-PFA-202403] TCR signaling [Pathway:R-PFA-6807070] PTEN Regulation
(hasEvent)	[Pathway:R-PFA-9006925] Intracellular signaling by second messengers
(inferredTo)	[Pathway:R-HSA-1257604] PIP3 activates AKT signaling

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