Reactome | Signaling by SCF-KIT

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Signaling by SCF-KIT Show undefined attributes

authored	[InstanceEdit:1433337] Garapati, P V, 2011-07-11
created	[InstanceEdit:1433555] Garapati, P V, 2011-07-11
dbId	1433557
diseasePathways	[Pathway:R-HSA-9669938] Signaling by KIT in disease - Homo sapiens [Pathway:R-HSA-9669933] Signaling by kinase domain mutants of KIT - Homo sapiens [Pathway:R-HSA-9669935] Signaling by juxtamembrane domain KIT mutants - Homo sapiens [Pathway:R-HSA-9680187] Signaling by extracellular domain mutants of KIT - Homo sapiens [Pathway:R-HSA-9670439] Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants - Homo sapiens [Pathway:R-HSA-9669937] Drug resistance of KIT mutants - Homo sapiens [Pathway:R-HSA-9669917] Imatinib-resistant KIT mutants - Homo sapiens [Pathway:R-HSA-9669934] Sunitinib-resistant KIT mutants - Homo sapiens [Pathway:R-HSA-9669929] Regorafenib-resistant KIT mutants - Homo sapiens [Pathway:R-HSA-9669914] Dasatinib-resistant KIT mutants - Homo sapiens [Pathway:R-HSA-9669924] Masitinib-resistant KIT mutants - Homo sapiens [Pathway:R-HSA-9669926] Nilotinib-resistant KIT mutants - Homo sapiens [Pathway:R-HSA-9669936] Sorafenib-resistant KIT mutants - Homo sapiens [Pathway:R-HSA-9669921] KIT mutants bind TKIs - Homo sapiens
displayName	Signaling by SCF-KIT
edited	[InstanceEdit:1433337] Garapati, P V, 2011-07-11
eventOf	[Pathway:R-HSA-9006934] Signaling by Receptor Tyrosine Kinases - Homo sapiens
figure	[Figure:2463863] /figures/Pathway_Illustrations/SCF-cKIT_72_oicr.png
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-1433374] Processing of SCF isoform 1 - Homo sapiens [Reaction:R-HSA-1433395] Dimerization of sSCF - Homo sapiens [Reaction:R-HSA-205321] Interaction of KIT and sSCF - Homo sapiens [Reaction:R-HSA-205231] Dimerization of KIT upon SCF binding - Homo sapiens [Reaction:R-HSA-205289] Autophosphorylation of KIT - Homo sapiens [Reaction:R-HSA-205262] Direct recruitment of PI3K to p-KIT - Homo sapiens [Reaction:R-HSA-1433514] Synthesis of PIP3 from PIP2 by PI3K - Homo sapiens [Reaction:R-HSA-1433542] Phosphorylation and activation of VAV1 - Homo sapiens [Reaction:R-HSA-1433415] Activation of RAC1 - Homo sapiens [Reaction:R-HSA-205205] Interaction of Src family kinases with p-KIT - Homo sapiens [Reaction:R-HSA-1472121] Phosphorylation of p-KIT on Y900 by Src kinases - Homo sapiens [Reaction:R-HSA-205286] GRB2:SOS interacts with p-KIT - Homo sapiens [Reaction:R-HSA-205238] SHP2 interacts with p-KIT - Homo sapiens [Reaction:R-HSA-1433488] Phosphorylation of SHP2 by SFKs - Homo sapiens [Reaction:R-HSA-1433428] GRB2 is indirectly recruited to p-KIT through SHP2 - Homo sapiens [Reaction:R-HSA-205234] Indirect recruitment of GAB2 to p-KIT - Homo sapiens [BlackBoxEvent:R-HSA-1433454] Phosphorylation of GAB2 by SFKs - Homo sapiens [Reaction:R-HSA-1562641] Indirect recruitment of PI3K to KIT via p(Y)-GAB2 - Homo sapiens [Reaction:R-HSA-1433471] Activation of RAS by p-KIT bound SOS1 - Homo sapiens [Reaction:R-HSA-205328] Interaction of other tyrosine kinases with p-KIT - Homo sapiens [Reaction:R-HSA-1433501] Interaction of other adapter proteins with p-KIT - Homo sapiens [Reaction:R-HSA-1433451] JAK2 binds to p-KIT - Homo sapiens [Reaction:R-HSA-1433418] Phosphorylation of JAK2 - Homo sapiens [Reaction:R-HSA-1433456] Recruitment of STATs - Homo sapiens [BlackBoxEvent:R-HSA-1470009] Phosphorylation of STATs - Homo sapiens [Reaction:R-HSA-1470010] Dimerization of STATs - Homo sapiens [Reaction:R-HSA-1470012] Disassociation and translocation of STATs to the nucleus - Homo sapiens [Pathway:R-HSA-1433559] Regulation of KIT signaling - Homo sapiens [Reaction:R-HSA-1433423] PTP-RO interacts with p-c-Kit complex - Homo sapiens [Reaction:R-HSA-9669854] KIT binds type II TKIs - Homo sapiens [Reaction:R-HSA-9669893] KIT binds type I TKIs - Homo sapiens [Reaction:R-HSA-9681375] KIT binds ripretinib - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2021-12-08
literatureReference	[LiteratureReference:1433358] c-Kit--a hematopoietic cell essential receptor tyrosine kinase [LiteratureReference:1433283] Signal transduction via the stem cell factor receptor/c-Kit [LiteratureReference:1433408] Stem cell factor and its receptor c-Kit as targets for inflammatory diseases [LiteratureReference:1433556] The stem cell factor receptor/c-Kit as a drug target in cancer [LiteratureReference:1472107] Oncogenic signaling from the hematopoietic growth factor receptors c-Kit and Flt3 [LiteratureReference:1562592] Expression of isoforms of the human receptor tyrosine kinase c-kit in leukemic cell lines and acute myeloid leukemia
maxDepth	3
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Signaling by SCF-KIT
orthologousEvent	[Pathway:R-DME-1433557] Signaling by SCF-KIT - Drosophila melanogaster [Pathway:R-CEL-1433557] Signaling by SCF-KIT - Caenorhabditis elegans [Pathway:R-GGA-1433557] Signaling by SCF-KIT - Gallus gallus [Pathway:R-MMU-1433557] Signaling by SCF-KIT - Mus musculus [Pathway:R-RNO-1433557] Signaling by SCF-KIT - Rattus norvegicus [Pathway:R-CFA-1433557] Signaling by SCF-KIT - Canis familiaris [Pathway:R-BTA-1433557] Signaling by SCF-KIT - Bos taurus [Pathway:R-SSC-1433557] Signaling by SCF-KIT - Sus scrofa [Pathway:R-DRE-1433557] Signaling by SCF-KIT - Danio rerio [Pathway:R-XTR-1433557] Signaling by SCF-KIT - Xenopus tropicalis
releaseDate	2011-09-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1500883] R�nnstrand, Lars, 2011-08-22
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-1433557
summation	[Summation:1433558] Stem cell factor (SCF) is a growth factor with membrane boun...
updateTrackers	[UpdateTracker:9784586] Update Tracker - [Pathway:1433557] Signaling by SCF-KIT - v53:[add_removeHasEvent] [UpdateTracker:9783691] Update Tracker - [Pathway:1433557] Signaling by SCF-KIT - v56:[updateContainedPathway] [UpdateTracker:9782367] Update Tracker - [Pathway:1433557] Signaling by SCF-KIT - v59:[updateContainedRLE, updateIndirectRLE] [UpdateTracker:9786686] Update Tracker - [Pathway:1433557] Signaling by SCF-KIT - v49:[modifyText] [UpdateTracker:9783890] Update Tracker - [Pathway:1433557] Signaling by SCF-KIT - v55:[updateIndirectRLE] [UpdateTracker:9779981] Update Tracker - [Pathway:1433557] Signaling by SCF-KIT - v64:[updateContainedRLE] [UpdateTracker:9784328] Update Tracker - [Pathway:1433557] Signaling by SCF-KIT - v54:[updateIndirectRLE] [UpdateTracker:9788524] Update Tracker - [Pathway:1433557] Signaling by SCF-KIT - v41:[updateContainedRLE, updateIndirectRLE] [UpdateTracker:9777045] Update Tracker - [Pathway:1433557] Signaling by SCF-KIT - v73:[addHasEvent, updateContainedRLE] [UpdateTracker:9775413] Update Tracker - [Pathway:1433557] Signaling by SCF-KIT - v79:[updateContainedRLE] [UpdateTracker:9782870] Update Tracker - [Pathway:1433557] Signaling by SCF-KIT - v58:[updateContainedPathway] [UpdateTracker:9788478] Update Tracker - [Pathway:1433557] Signaling by SCF-KIT - v42:[updateContainedPathway, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9780765] Update Tracker - [Pathway:1433557] Signaling by SCF-KIT - v62:[removeHasEvent] [UpdateTracker:9777199] Update Tracker - [Pathway:1433557] Signaling by SCF-KIT - v72:[updateContainedRLE] [UpdateTracker:9781493] Update Tracker - [Pathway:1433557] Signaling by SCF-KIT - v61:[updateContainedPathway, updateIndirectRLE]

Referrals

(hasEvent)	[Pathway:R-HSA-9006934] Signaling by Receptor Tyrosine Kinases
(hasEncapsulatedEvent)	[Pathway:R-HSA-1257604] PIP3 activates AKT signaling [Pathway:R-HSA-5673001] RAF/MAP kinase cascade
(normalPathway)	[Pathway:R-HSA-9669938] Signaling by KIT in disease [Pathway:R-HSA-9669933] Signaling by kinase domain mutants of KIT [Pathway:R-HSA-9669935] Signaling by juxtamembrane domain KIT mutants [Pathway:R-HSA-9680187] Signaling by extracellular domain mutants of KIT [Pathway:R-HSA-9670439] Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants [Pathway:R-HSA-9669937] Drug resistance of KIT mutants [Pathway:R-HSA-9669917] Imatinib-resistant KIT mutants [Pathway:R-HSA-9669934] Sunitinib-resistant KIT mutants [Pathway:R-HSA-9669929] Regorafenib-resistant KIT mutants [Pathway:R-HSA-9669914] Dasatinib-resistant KIT mutants [Pathway:R-HSA-9669924] Masitinib-resistant KIT mutants [Pathway:R-HSA-9669926] Nilotinib-resistant KIT mutants [Pathway:R-HSA-9669936] Sorafenib-resistant KIT mutants [Pathway:R-HSA-9669921] KIT mutants bind TKIs
(updatedInstance)	[UpdateTracker:9784586] Update Tracker - [Pathway:1433557] Signaling by SCF-KIT - v53:[add_removeHasEvent] [UpdateTracker:9783691] Update Tracker - [Pathway:1433557] Signaling by SCF-KIT - v56:[updateContainedPathway] [UpdateTracker:9782367] Update Tracker - [Pathway:1433557] Signaling by SCF-KIT - v59:[updateContainedRLE, updateIndirectRLE] [UpdateTracker:9786686] Update Tracker - [Pathway:1433557] Signaling by SCF-KIT - v49:[modifyText] [UpdateTracker:9783890] Update Tracker - [Pathway:1433557] Signaling by SCF-KIT - v55:[updateIndirectRLE] [UpdateTracker:9779981] Update Tracker - [Pathway:1433557] Signaling by SCF-KIT - v64:[updateContainedRLE] [UpdateTracker:9784328] Update Tracker - [Pathway:1433557] Signaling by SCF-KIT - v54:[updateIndirectRLE] [UpdateTracker:9788524] Update Tracker - [Pathway:1433557] Signaling by SCF-KIT - v41:[updateContainedRLE, updateIndirectRLE] [UpdateTracker:9777045] Update Tracker - [Pathway:1433557] Signaling by SCF-KIT - v73:[addHasEvent, updateContainedRLE] [UpdateTracker:9775413] Update Tracker - [Pathway:1433557] Signaling by SCF-KIT - v79:[updateContainedRLE] [UpdateTracker:9782870] Update Tracker - [Pathway:1433557] Signaling by SCF-KIT - v58:[updateContainedPathway] [UpdateTracker:9788478] Update Tracker - [Pathway:1433557] Signaling by SCF-KIT - v42:[updateContainedPathway, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9780765] Update Tracker - [Pathway:1433557] Signaling by SCF-KIT - v62:[removeHasEvent] [UpdateTracker:9777199] Update Tracker - [Pathway:1433557] Signaling by SCF-KIT - v72:[updateContainedRLE] [UpdateTracker:9781493] Update Tracker - [Pathway:1433557] Signaling by SCF-KIT - v61:[updateContainedPathway, updateIndirectRLE]

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