Reactome | RHO GTPases activate PKNs

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RHO GTPases activate PKNs Show undefined attributes

authored	[InstanceEdit:5628889] Orlic-Milacic, Marija, 2014-10-24 [InstanceEdit:5668821] Rivero Crespo, Francisco, 2014-12-26
created	[InstanceEdit:5625741] Orlic-Milacic, Marija, 2014-10-07
dbId	5625740
displayName	RHO GTPases activate PKNs
edited	[InstanceEdit:5671747] Orlic-Milacic, Marija, 2015-02-02
eventOf	[Pathway:R-HSA-195258] RHO GTPase Effectors - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-5623622] RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 - Homo sapiens [Reaction:R-HSA-5623632] RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 - Homo sapiens [Reaction:R-HSA-5623667] PDPK1 phosphorylates PKN1,2,3 - Homo sapiens [Pathway:R-HSA-5625886] Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 - Homo sapiens [Reaction:R-HSA-5671737] p-T774-PKN1 binds CDC25C - Homo sapiens [Reaction:R-HSA-5671749] p-T774-PKN1 phosphorylates CDC25C - Homo sapiens [Reaction:R-HSA-75016] Association of p-S216-CDC25C with 14-3-3 proteins - Homo sapiens [Reaction:R-HSA-5671763] p-T774-PKN1 phosphorylates PPP1R14A - Homo sapiens [Reaction:R-HSA-5671772] p-T38-PPP1R14A binds MLCP - Homo sapiens [Reaction:R-HSA-419232] Myosin phosphatase dephosphorylates myosin regulatory light chain - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2017-06-22
literatureReference	[LiteratureReference:5623615] Differential binding of RhoA, RhoB, and RhoC to protein kinase C-related kinase (PRK) isoforms PRK1, PRK2, and PRK3: PRKs have the highest affinity for RhoB [LiteratureReference:5623625] Mutational analysis reveals a single binding interface between RhoA and its effector, PRK1 [LiteratureReference:5623619] The structural basis of Rho effector recognition revealed by the crystal structure of human RhoA complexed with the effector domain of PKN/PRK1 [LiteratureReference:5624312] Molecular dissection of the interaction between the small G proteins Rac1 and RhoA and protein kinase C-related kinase 1 (PRK1) [LiteratureReference:5624309] The Rac1 polybasic region is required for interaction with its effector PRK1 [LiteratureReference:5624305] Loop 6 of RhoA confers specificity for effector binding, stress fiber formation, and cellular transformation [LiteratureReference:5623634] Rho GTPase control of protein kinase C-related protein kinase activation by 3-phosphoinositide-dependent protein kinase [LiteratureReference:5623676] Hyperosmotic-induced protein kinase N 1 activation in a vesicular compartment is dependent upon Rac1 and 3-phosphoinositide-dependent kinase 1 [LiteratureReference:5623665] Regulation of the interaction between protein kinase C-related protein kinase 2 (PRK2) and its upstream kinase, 3-phosphoinositide-dependent protein kinase 1 (PDK1) [LiteratureReference:5669270] Site recognition and substrate screens for PKN family proteins [LiteratureReference:5669271] Mutational analysis of the regulatory mechanism of PKN: the regulatory region of PKN contains an arachidonic acid-sensitive autoinhibitory domain [LiteratureReference:5669274] Activation of PRK1 by phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. A comparison with protein kinase C isotypes [LiteratureReference:5671798] Phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by protein kinase N [LiteratureReference:5671750] PKN delays mitotic timing by inhibition of Cdc25C: possible involvement of PKN in the regulation of cell division [LiteratureReference:5671801] Interaction of PKN with alpha-actinin [LiteratureReference:5671781] Domain-specific phosphorylation of vimentin and glial fibrillary acidic protein by PKN [LiteratureReference:5671803] Negative regulation of constitutive NF-kappaB and JNK signaling by PKN1-mediated phosphorylation of TRAF1
maxDepth	3
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	RHO GTPases activate PKNs
orthologousEvent	[Pathway:R-DDI-5625740] RHO GTPases activate PKNs - Dictyostelium discoideum [Pathway:R-GGA-5625740] RHO GTPases activate PKNs - Gallus gallus [Pathway:R-DME-5625740] RHO GTPases activate PKNs - Drosophila melanogaster [Pathway:R-MMU-5625740] RHO GTPases activate PKNs - Mus musculus [Pathway:R-RNO-5625740] RHO GTPases activate PKNs - Rattus norvegicus [Pathway:R-CFA-5625740] RHO GTPases activate PKNs - Canis familiaris [Pathway:R-BTA-5625740] RHO GTPases activate PKNs - Bos taurus [Pathway:R-SSC-5625740] RHO GTPases activate PKNs - Sus scrofa [Pathway:R-CEL-5625740] RHO GTPases activate PKNs - Caenorhabditis elegans [Pathway:R-DRE-5625740] RHO GTPases activate PKNs - Danio rerio [Pathway:R-XTR-5625740] RHO GTPases activate PKNs - Xenopus tropicalis [Pathway:R-SPO-5625740] RHO GTPases activate PKNs - Schizosaccharomyces pombe [Pathway:R-SCE-5625740] RHO GTPases activate PKNs - Saccharomyces cerevisiae
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5625740
summation	[Summation:5627095] Protein kinases N (PKN), also known as protein kinase C-rela...
updateTrackers	[UpdateTracker:9781048] Update Tracker - [Pathway:5625740] RHO GTPases activate PKNs - v61:[updateContainedRLE]

Referrals

(hasEvent)	[Pathway:R-HSA-195258] RHO GTPase Effectors
(hasEncapsulatedEvent)	[Pathway:R-HSA-8848021] Signaling by PTK6 [Pathway:R-HSA-5625886] Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 [Pathway:R-HSA-5625900] RHO GTPases activate CIT
(updatedInstance)	[UpdateTracker:9781048] Update Tracker - [Pathway:5625740] RHO GTPases activate PKNs - v61:[updateContainedRLE]

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