Reactome | PDPK1 phosphorylates AKT at T308

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PDPK1 phosphorylates AKT at T308 Show undefined attributes

authored	[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
catalystActivity	[CatalystActivity:198343] protein serine/threonine kinase activity of p-S-AKT:PDPK1:PIP3 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:198310] 2007-07-10 08:01:55
dbId	198270
displayName	PDPK1 phosphorylates AKT at T308
edited	[InstanceEdit:2426555] Matthews, L, 2012-08-03
eventOf	[Pathway:R-HSA-9755779] SARS-CoV-2 targets host intracellular signalling and regulatory pathways - Homo sapiens [Pathway:R-HSA-389357] CD28 dependent PI3K/Akt signaling - Homo sapiens [Pathway:R-HSA-5218920] VEGFR2 mediated vascular permeability - Homo sapiens
followingEvent	[Reaction:R-HSA-8933446] Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling - Homo sapiens [Reaction:R-HSA-198298] AKT translocates to the nucleus - Homo sapiens [Reaction:R-HSA-198599] AKT phosphorylates MDM2 - Homo sapiens [Reaction:R-HSA-198613] AKT phosphorylates p21Cip1 and p27Kip1 - Homo sapiens [Reaction:R-HSA-198347] AKT phosphorylates BAD - Homo sapiens [Reaction:R-HSA-198371] AKT phosphorylates GSK3 - Homo sapiens [Reaction:R-HSA-198611] AKT phosphorylates IKKalpha - Homo sapiens [Reaction:R-HSA-198609] AKT phosphorylates TSC2, inhibiting it - Homo sapiens [Reaction:R-HSA-200143] AKT phosphorylates AKT1S1 (PRAS40) - Homo sapiens [Reaction:R-HSA-8948757] AKT phosphorylates MKRN1 - Homo sapiens [Reaction:R-HSA-198621] AKT phosphorylates caspase-9 - Homo sapiens [Reaction:R-HSA-1358791] Phosphorylation of USP8 by P-AKT - Homo sapiens [Reaction:R-HSA-389756] AKT interacts and phosphorylates Cot - Homo sapiens [Reaction:R-HSA-165162] Phosphorylation of TSC2 by AKT (PKB) - Homo sapiens [Reaction:R-HSA-165182] Phosphorylation of complexed TSC2 by PKB - Homo sapiens [Reaction:R-HSA-6805640] AKT phosphorylates KAT6A - Homo sapiens [Reaction:R-HSA-6805785] AKT phosphorylates PHF20 - Homo sapiens [Reaction:R-HSA-9604328] AKT1 phosphorylates NOTCH4 - Homo sapiens [Reaction:R-HSA-377186] Activated AKT phosphorylates AKT1S1 (PRAS40) - Homo sapiens [Reaction:R-HSA-202137] AKT1 binds eNOS complex via HSP90 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-2317313] p-S-AKT:PDPK1:PIP3 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:199386] Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase [LiteratureReference:199355] Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
maxDepth	1
modified	[InstanceEdit:9831004] D'Eustachio, Peter, 2023-03-17
name	PDPK1 phosphorylates AKT at T308
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [CandidateSet:R-HSA-202074] p-T,p-S-AKT [cytosol] [Complex:R-HSA-377179] PDPK1:PIP3 [plasma membrane]
precedingEvent	[Reaction:R-HSA-2317314] AKT binds PDPK1 - Homo sapiens
regulatedBy	[NegativeRegulation:9766197] Negative regulation by 'N:M:PDPK1 [plasma membrane]'
regulationReference	[RegulationReference:9766208] Negative regulation by 'N:M:PDPK1 [plasma membrane]' SARS-CoV-2 Membrane Glycoprotein M Triggers Apoptosis With the Assistance of Nucleocapsid Protein N in Cells
releaseDate	2008-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37 [InstanceEdit:2463860] Thorpe, Lauren, 2012-08-13 [InstanceEdit:2463859] Yuzugullu, Haluk, 2012-08-13 [InstanceEdit:2463854] Zhao, Jean J, 2012-08-13 [InstanceEdit:9766195] Messina, Francesco, 2022-02-18
revised	[InstanceEdit:2422427] Orlic-Milacic, M, 2012-07-18
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-198270
summation	[Summation:198363] Once AKT is localized at the plasma membrane, it is phosphor...
updateTrackers	[UpdateTracker:9791324] Update Tracker - [Reaction:198270] PDPK1 phosphorylates AKT at T308 - v31:[modifyText] [UpdateTracker:9775001] Update Tracker - [Reaction:198270] PDPK1 phosphorylates AKT at T308 - v80:[addRegulator] [UpdateTracker:9788458] Update Tracker - [Reaction:198270] PDPK1 phosphorylates AKT at T308 - v42:[add_removeInput, add_removeOutput, modifyText, removeRegulator]

Referrals

(precedingEvent)	[Reaction:R-HSA-8933446] Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling [NegativePrecedingEvent:9866005] Futile Cycle: PDPK1 phosphorylates AKT at T308 [Reaction:R-HSA-198298] AKT translocates to the nucleus [Reaction:R-HSA-198599] AKT phosphorylates MDM2 [Reaction:R-HSA-198613] AKT phosphorylates p21Cip1 and p27Kip1 [Reaction:R-HSA-198347] AKT phosphorylates BAD [Reaction:R-HSA-198371] AKT phosphorylates GSK3 [Reaction:R-HSA-198611] AKT phosphorylates IKKalpha [Reaction:R-HSA-198609] AKT phosphorylates TSC2, inhibiting it [Reaction:R-HSA-200143] AKT phosphorylates AKT1S1 (PRAS40) [Reaction:R-HSA-8948757] AKT phosphorylates MKRN1 [Reaction:R-HSA-198621] AKT phosphorylates caspase-9 [Reaction:R-HSA-1358791] Phosphorylation of USP8 by P-AKT [Reaction:R-HSA-9604328] AKT1 phosphorylates NOTCH4 [Reaction:R-HSA-389756] AKT interacts and phosphorylates Cot [Reaction:R-HSA-377186] Activated AKT phosphorylates AKT1S1 (PRAS40) [Reaction:R-HSA-165162] Phosphorylation of TSC2 by AKT (PKB) [Reaction:R-HSA-165182] Phosphorylation of complexed TSC2 by PKB [Reaction:R-HSA-202137] AKT1 binds eNOS complex via HSP90 [Reaction:R-HSA-6805640] AKT phosphorylates KAT6A [Reaction:R-HSA-6805785] AKT phosphorylates PHF20
(hasEvent)	[Pathway:R-HSA-9755779] SARS-CoV-2 targets host intracellular signalling and regulatory pathways [Pathway:R-HSA-389357] CD28 dependent PI3K/Akt signaling [Pathway:R-HSA-5218920] VEGFR2 mediated vascular permeability [Pathway:R-HSA-1257604] PIP3 activates AKT signaling
(updatedInstance)	[UpdateTracker:9791324] Update Tracker - [Reaction:198270] PDPK1 phosphorylates AKT at T308 - v31:[modifyText] [UpdateTracker:9775001] Update Tracker - [Reaction:198270] PDPK1 phosphorylates AKT at T308 - v80:[addRegulator] [UpdateTracker:9788458] Update Tracker - [Reaction:198270] PDPK1 phosphorylates AKT at T308 - v42:[add_removeInput, add_removeOutput, modifyText, removeRegulator]

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