Reactome | Signaling by NTRK2 (TRKB)

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Signaling by NTRK2 (TRKB) Show undefined attributes

authored	[InstanceEdit:9034391] Orlic-Milacic, Marija, 2018-01-05
created	[InstanceEdit:9006116] Orlic-Milacic, Marija, 2017-05-12
dbId	9006115
displayName	Signaling by NTRK2 (TRKB)
doi	10.3180/R-HSA-9006115.1
edited	[InstanceEdit:9037703] Orlic-Milacic, Marija, 2018-02-20
eventOf	[Pathway:R-HSA-166520] Signaling by NTRKs - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:182] neurotrophin TRK receptor signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-HSA-9024909] BDNF activates NTRK2 (TRKB) signaling - Homo sapiens [Pathway:R-HSA-9025046] NTF3 activates NTRK2 (TRKB) signaling - Homo sapiens [Pathway:R-HSA-9026357] NTF4 activates NTRK2 (TRKB) signaling - Homo sapiens [Pathway:R-HSA-9026519] Activated NTRK2 signals through RAS - Homo sapiens [Pathway:R-HSA-9026527] Activated NTRK2 signals through PLCG1 - Homo sapiens [Pathway:R-HSA-9028335] Activated NTRK2 signals through PI3K - Homo sapiens [Pathway:R-HSA-9028731] Activated NTRK2 signals through FRS2 and FRS3 - Homo sapiens [Pathway:R-HSA-9032500] Activated NTRK2 signals through FYN - Homo sapiens [Pathway:R-HSA-9032845] Activated NTRK2 signals through CDK5 - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9032492] A loss-of-function screen for phosphatases that regulate neurite outgrowth identifies PTPN12 as a negative regulator of TrkB tyrosine phosphorylation [LiteratureReference:9032634] TrkB activation by brain-derived neurotrophic factor inhibits the G protein-gated inward rectifier Kir3 by tyrosine phosphorylation of the channel [LiteratureReference:9032836] SLAM-associated protein as a potential negative regulator in Trk signaling [LiteratureReference:9033382] A Review on Ubiquitination of Neurotrophin Receptors: Facts and Perspectives [LiteratureReference:9033370] Identification of a consensus site for TRAF6/p62 polyubiquitination [LiteratureReference:9033369] Glucocorticoid regulates TrkB protein levels via c-Cbl dependent ubiquitination: a decrease in c-Cbl mRNA in the prefrontal cortex of suicide subjects [LiteratureReference:9033367] Differential effects of BDNF and neurotrophin 4 (NT4) on endocytic sorting of TrkB receptors [LiteratureReference:9033437] TrkB signalling pathways in LTP and learning
maxDepth	4
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Signaling by NTRK2 (TRKB)
orthologousEvent	[Pathway:R-GGA-9006115] Signaling by NTRK2 (TRKB) - Gallus gallus [Pathway:R-XTR-9006115] Signaling by NTRK2 (TRKB) - Xenopus tropicalis [Pathway:R-SSC-9006115] Signaling by NTRK2 (TRKB) - Sus scrofa [Pathway:R-BTA-9006115] Signaling by NTRK2 (TRKB) - Bos taurus [Pathway:R-CFA-9006115] Signaling by NTRK2 (TRKB) - Canis familiaris [Pathway:R-RNO-9006115] Signaling by NTRK2 (TRKB) - Rattus norvegicus [Pathway:R-MMU-9006115] Signaling by NTRK2 (TRKB) - Mus musculus
releaseDate	2018-03-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9037707] Antila, Hanna, 2018-02-13 [InstanceEdit:9037710] Castr�n, Eero, 2018-02-13
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9006115
summation	[Summation:9032488] NTRK2 (TRKB) belongs to the family of neurotrophin tyrosine ...

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[Pathway:R-HSA-166520] Signaling by NTRKs

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