Reactome | Constitutive Signaling by Aberrant PI3K in Cancer

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Constitutive Signaling by Aberrant PI3K in Cancer Show undefined attributes

authored	[InstanceEdit:2422427] Orlic-Milacic, M, 2012-07-18
created	[InstanceEdit:2219531] Orlic-Milacic, M, 2012-05-01
crossReference	[DatabaseIdentifier:12819465] BioModels Database:BIOMD0000000255 [DatabaseIdentifier:12020745] Mondo:0004992 [DatabaseIdentifier:12819467] BioModels Database:BIOMD0000000581 [DatabaseIdentifier:12819469] BioModels Database:BIOMD0000000724 [DatabaseIdentifier:12819471] BioModels Database:BIOMD0000000175 [DatabaseIdentifier:12819431] BioModels Database:BIOMD0000000883
dbId	2219530
disease	[Disease:1500689] cancer
displayName	Constitutive Signaling by Aberrant PI3K in Cancer
eventOf	[Pathway:R-HSA-2219528] PI3K/AKT Signaling in Cancer - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-2394007] PI3K gain of function mutants phosphorylate PIP2 to PIP3 - Homo sapiens [Reaction:R-HSA-2400009] PI3K inhibitors block PI3K catalytic activity - Homo sapiens
isInDisease	true
isInferred	false
lastUpdatedDate	2015-03-23
literatureReference	[LiteratureReference:2399562] The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations [LiteratureReference:2399575] The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells [LiteratureReference:2399592] Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit [LiteratureReference:2399617] Mutations in the catalytic subunit of class IA PI3K confer leukemogenic potential to hematopoietic cells [LiteratureReference:2399685] Cancer-derived mutations in the regulatory subunit p85alpha of phosphoinositide 3-kinase function through the catalytic subunit p110alpha [LiteratureReference:2399688] Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation [LiteratureReference:2399690] PIK3R1 (p85?) is somatically mutated at high frequency in primary endometrial cancer [LiteratureReference:2458350] Hot-spot mutations in p110alpha of phosphatidylinositol 3-kinase (pI3K): differential interactions with the regulatory subunit p85 and with RAS
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Constitutive Signaling by Aberrant PI3K in Cancer
normalPathway	[Pathway:R-HSA-1257604] PIP3 activates AKT signaling
releaseDate	2012-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2463860] Thorpe, Lauren, 2012-08-13 [InstanceEdit:2463859] Yuzugullu, Haluk, 2012-08-13 [InstanceEdit:2463854] Zhao, Jean J, 2012-08-13
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-2219530
summation	[Summation:5674401] Signaling by PI3K/AKT is frequently constitutively activated...
updateTrackers	[UpdateTracker:9785292] Update Tracker - [Pathway:2219530] Constitutive Signaling by Aberrant PI3K in Cancer - v52:[add_removeLiteratureReference, add_removeSummation, removeHasEvent] [UpdateTracker:9788032] Update Tracker - [Pathway:2219530] Constitutive Signaling by Aberrant PI3K in Cancer - v44:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9785292] Update Tracker - [Pathway:2219530] Constitutive Signaling by Aberrant PI3K in Cancer - v52:[add_removeLiteratureReference, add_removeSummation, removeHasEvent] [UpdateTracker:9788032] Update Tracker - [Pathway:2219530] Constitutive Signaling by Aberrant PI3K in Cancer - v44:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-2219528] PI3K/AKT Signaling in Cancer

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