Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
Schema
>
Pathway
>
Entries
Constitutive Signaling by Aberrant PI3K in Cancer
Show undefined attributes
Go to Details
authored
[InstanceEdit:2422427] Orlic-Milacic, M, 2012-07-18
created
[InstanceEdit:2219531] Orlic-Milacic, M, 2012-05-01
crossReference
[DatabaseIdentifier:12325424] BioModels Database:BIOMD0000000255
[DatabaseIdentifier:12325426] BioModels Database:BIOMD0000000581
[DatabaseIdentifier:12325428] BioModels Database:BIOMD0000000724
[DatabaseIdentifier:12325430] BioModels Database:BIOMD0000000175
[DatabaseIdentifier:12325346] BioModels Database:BIOMD0000000883
dbId
2219530
disease
[Disease:1500689] cancer
displayName
Constitutive Signaling by Aberrant PI3K in Cancer
eventOf
[Pathway:R-HSA-2219528] PI3K/AKT Signaling in Cancer - Homo sapiens
hasDiagram
true
hasEHLD
false
hasEvent
[Reaction:R-HSA-2394007] PI3K gain of function mutants phosphorylate PIP2 to PIP3 - Homo sapiens
[Reaction:R-HSA-2400009] PI3K inhibitors block PI3K catalytic activity - Homo sapiens
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:2399562] The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations
[LiteratureReference:2399575] The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells
[LiteratureReference:2399592] Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit
[LiteratureReference:2399617] Mutations in the catalytic subunit of class IA PI3K confer leukemogenic potential to hematopoietic cells
[LiteratureReference:2399685] Cancer-derived mutations in the regulatory subunit p85alpha of phosphoinositide 3-kinase function through the catalytic subunit p110alpha
[LiteratureReference:2399688] Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation
[LiteratureReference:2399690] PIK3R1 (p85?) is somatically mutated at high frequency in primary endometrial cancer
[LiteratureReference:2458350] Hot-spot mutations in p110alpha of phosphatidylinositol 3-kinase (pI3K): differential interactions with the regulatory subunit p85 and with RAS
modified
[InstanceEdit:12325341] Wright, Adam, 2024-02-14
name
Constitutive Signaling by Aberrant PI3K in Cancer
normalPathway
[Pathway:R-HSA-1257604] PIP3 activates AKT signaling
releaseDate
2012-09-18
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2463860] Thorpe, Lauren, 2012-08-13
[InstanceEdit:2463859] Yuzugullu, Haluk, 2012-08-13
[InstanceEdit:2463854] Zhao, Jean J, 2012-08-13
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-2219530
summation
[Summation:5674401] Signaling by PI3K/AKT is frequently constitutively activated...
Referrals
(hasEvent)
[Pathway:R-HSA-2219528] PI3K/AKT Signaling in Cancer
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text