Reactome | GPVI-mediated activation cascade

Schema > Pathway > Entries

GPVI-mediated activation cascade Show undefined attributes

created	[InstanceEdit:141659] de Bono, B, Pace, N.P., Farndale, R, 2004-09-25 17:06:19
dbId	114604
deleted	[Deleted:9028752] Deletion of instance: 139943
displayName	GPVI-mediated activation cascade
doi	10.3180/R-HSA-114604.2
edited	[InstanceEdit:445674] Jupe, S, 2009-11-03 [InstanceEdit:9032145] Orlic-Milacic, Marija, 2017-12-06
eventOf	[Pathway:R-HSA-76002] Platelet activation, signaling and aggregation - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-114600] Fyn/Lyn-mediated phosphorylation of FcR1 gamma - Homo sapiens [Reaction:R-HSA-139842] Binding of Syk tyrosine kinase - Homo sapiens [Reaction:R-HSA-453200] SYK autophosphorylates - Homo sapiens [Reaction:R-HSA-453183] p-Y348-SYK dissociates - Homo sapiens [Reaction:R-HSA-437932] p-Y348-SYK binds VAV family - Homo sapiens [Reaction:R-HSA-437936] p-Y348-SYK phosphorylates VAV family - Homo sapiens [Reaction:R-HSA-442273] VAV1 is a GEF for Rho/Rac family GTPases - Homo sapiens [Reaction:R-HSA-442291] VAV2 is a GEF for Rho/Rac family kinases - Homo sapiens [Reaction:R-HSA-442314] VAV3 is a GEF for Rho/Rac family kinases - Homo sapiens [Reaction:R-HSA-434836] Syk/Lck phosphorylate LAT - Homo sapiens [Reaction:R-HSA-429449] Syk activation leads to SLP-76 activation - Homo sapiens [BlackBoxEvent:R-HSA-429497] SLP-76 stimulates PLC gamma 2 - Homo sapiens [Reaction:R-HSA-430158] p-SLP-76 binds VAV - Homo sapiens [Reaction:R-HSA-114689] PLC gamma 2-mediated PIP2 hydrolysis - Homo sapiens [Reaction:R-HSA-434637] PI(3,4,5)P3 binds VAV1,2,3 - Homo sapiens [Reaction:R-HSA-434633] PIP2 binds inhibiting VAV - Homo sapiens [BlackBoxEvent:R-HSA-437118] GPVI stimulates PI3K beta, gamma - Homo sapiens [Reaction:R-HSA-437162] PI3K alpha, beta, gamma convert PIP2 to PIP3 - Homo sapiens [Reaction:R-HSA-2316429] PIP3 recruits PDPK1 to the membrane - Homo sapiens [Reaction:R-HSA-437192] PDPK1 binds PRKCZ - Homo sapiens [Reaction:R-HSA-437195] PDPK1 activates PRKCZ - Homo sapiens [Reaction:R-HSA-5684169] G6B binds PTPN6,PTPN11 - Homo sapiens [Reaction:R-HSA-5684836] CLEC1B dimer binds PDPN - Homo sapiens [BlackBoxEvent:R-HSA-5684806] Unknown kinase phosphorylates CLEC1B dimer:PDPN - Homo sapiens [Reaction:R-HSA-5684801] p-Y7-CLEC1B dimer:PDPN binds SYK - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2019-03-25
literatureReference	[LiteratureReference:210193] Association of Fyn and Lyn with the proline-rich domain of glycoprotein VI regulates intracellular signaling [LiteratureReference:210067] GPVI and integrin alphaIIb beta3 signaling in platelets
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	GPVI-mediated activation cascade
orthologousEvent	[Pathway:R-MMU-114604] GPVI-mediated activation cascade - Mus musculus [Pathway:R-RNO-114604] GPVI-mediated activation cascade - Rattus norvegicus [Pathway:R-CFA-114604] GPVI-mediated activation cascade - Canis familiaris [Pathway:R-BTA-114604] GPVI-mediated activation cascade - Bos taurus [Pathway:R-SSC-114604] GPVI-mediated activation cascade - Sus scrofa [Pathway:R-DRE-114604] GPVI-mediated activation cascade - Danio rerio [Pathway:R-XTR-114604] GPVI-mediated activation cascade - Xenopus tropicalis [Pathway:R-GGA-114604] GPVI-mediated activation cascade - Gallus gallus [Pathway:R-DME-114604] GPVI-mediated activation cascade - Drosophila melanogaster [Pathway:R-CEL-114604] GPVI-mediated activation cascade - Caenorhabditis elegans [Pathway:R-DDI-114604] GPVI-mediated activation cascade - Dictyostelium discoideum [Pathway:R-SPO-114604] GPVI-mediated activation cascade - Schizosaccharomyces pombe [Pathway:R-SCE-114604] GPVI-mediated activation cascade - Saccharomyces cerevisiae [Pathway:R-PFA-114604] GPVI-mediated activation cascade - Plasmodium falciparum
releaseDate	2004-10-27
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-114604
summation	[Summation:432300] The GPVI receptor is a complex of the GPVI protein with Fc e...
updateTrackers	[UpdateTracker:9791326] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v31:[addHasEvent, updateContainedRLE] [UpdateTracker:9780163] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v64:[add_removeHasEvent, updateContainedRLE] [UpdateTracker:9784854] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v53:[updateContainedRLE] [UpdateTracker:9791215] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v32:[updateContainedRLE] [UpdateTracker:9787559] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v44:[updateContainedRLE] [UpdateTracker:9784495] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v54:[updateContainedRLE] [UpdateTracker:9784011] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v55:[addHasEvent] [UpdateTracker:9782354] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v59:[updateContainedRLE] [UpdateTracker:9792182] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v23:[updateContainedRLE] [UpdateTracker:9790195] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v34:[addHasEvent] [UpdateTracker:9782723] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v58:[updateContainedRLE] [UpdateTracker:9786357] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v49:[updateContainedRLE] [UpdateTracker:9791458] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v30:[addLiteratureReference, addSummation, add_removeHasEvent, updateContainedRLE] [UpdateTracker:9778610] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v68:[updateContainedRLE]

Referrals

(hasEvent)	[Pathway:R-HSA-76002] Platelet activation, signaling and aggregation
(replacementInstances)	[Deleted:9028752] Deletion of instance: 139943
(updatedInstance)	[UpdateTracker:9791326] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v31:[addHasEvent, updateContainedRLE] [UpdateTracker:9780163] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v64:[add_removeHasEvent, updateContainedRLE] [UpdateTracker:9784854] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v53:[updateContainedRLE] [UpdateTracker:9791215] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v32:[updateContainedRLE] [UpdateTracker:9787559] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v44:[updateContainedRLE] [UpdateTracker:9784495] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v54:[updateContainedRLE] [UpdateTracker:9784011] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v55:[addHasEvent] [UpdateTracker:9782354] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v59:[updateContainedRLE] [UpdateTracker:9792182] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v23:[updateContainedRLE] [UpdateTracker:9790195] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v34:[addHasEvent] [UpdateTracker:9782723] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v58:[updateContainedRLE] [UpdateTracker:9786357] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v49:[updateContainedRLE] [UpdateTracker:9791458] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v30:[addLiteratureReference, addSummation, add_removeHasEvent, updateContainedRLE] [UpdateTracker:9778610] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v68:[updateContainedRLE]

Cite Us!