Reactome | Signaling by ALK

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Signaling by ALK Show undefined attributes

authored	[InstanceEdit:201555] Jassal, B, 2007-08-21 12:54:41
created	[InstanceEdit:201555] Jassal, B, 2007-08-21 12:54:41
dbId	201556
diseasePathways	[Pathway:R-HSA-9700206] Signaling by ALK in cancer - Homo sapiens [Pathway:R-HSA-9725370] Signaling by ALK fusions and activated point mutants - Homo sapiens [Pathway:R-HSA-9700649] Drug resistance of ALK mutants - Homo sapiens [Pathway:R-HSA-9717323] ceritinib-resistant ALK mutants - Homo sapiens [Pathway:R-HSA-9717326] crizotinib-resistant ALK mutants - Homo sapiens [Pathway:R-HSA-9717329] lorlatinib-resistant ALK mutants - Homo sapiens [Pathway:R-HSA-9717264] ASP-3026-resistant ALK mutants - Homo sapiens [Pathway:R-HSA-9717319] brigatinib-resistant ALK mutants - Homo sapiens [Pathway:R-HSA-9717301] NVP-TAE684-resistant ALK mutants - Homo sapiens [Pathway:R-HSA-9717316] alectinib-resistant ALK mutants - Homo sapiens [Pathway:R-HSA-9700645] ALK mutants bind TKIs - Homo sapiens
displayName	Signaling by ALK
doi	10.3180/R-HSA-201556.4
edited	[InstanceEdit:201559] Jassal, B, 2007-08-21 12:55:28
eventOf	[Pathway:R-HSA-9006934] Signaling by Receptor Tyrosine Kinases - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-9842656] ALK binds ALKAL ligand - Homo sapiens [Pathway:R-HSA-9851151] MDK and PTN in ALK signaling - Homo sapiens [Reaction:R-HSA-201521] ALK autophosphorylation - Homo sapiens [Reaction:R-HSA-9700662] Liganded-ALK dimer binds type I ALK-binding TKIs - Homo sapiens [Reaction:R-HSA-9700156] Active ALK dimer binds IRS1 - Homo sapiens [Reaction:R-HSA-9700168] Active ALK phosphorylates IRS1 - Homo sapiens [Reaction:R-HSA-9700154] Active ALK binds SHC1 - Homo sapiens [Reaction:R-HSA-9700175] Active ALK phosphorylates SHC1 - Homo sapiens [Reaction:R-HSA-9700142] Active ALK binds FRS2 - Homo sapiens [Reaction:R-HSA-9700164] Active ALK phosphorylates FRS2 - Homo sapiens [BlackBoxEvent:R-HSA-201515] Active ALK recruits PI3K - Homo sapiens [Reaction:R-HSA-201510] PI3K synthesizes PIP3 downstream of ALK - Homo sapiens [Reaction:R-HSA-9700149] Active ALK binds PLCG1 - Homo sapiens [Reaction:R-HSA-9700171] Active ALK phosphorylates PLCG1 - Homo sapiens [Reaction:R-HSA-9700648] Active ALK binds SRC - Homo sapiens [Reaction:R-HSA-9700647] Active ALK phosphorylates SRC - Homo sapiens [Reaction:R-HSA-9701485] Active ALK binds JAK3 - Homo sapiens [Reaction:R-HSA-9701488] Active ALK phosphorylates JAK3 - Homo sapiens [Reaction:R-HSA-9701507] PTPN6 dephosphorylates JAK3 - Homo sapiens [BlackBoxEvent:R-HSA-9701524] STAT3 is phosphorylated downstream of active ALK - Homo sapiens [Reaction:R-HSA-9701525] p-Y705,S727-STAT3 dimerizes - Homo sapiens [BlackBoxEvent:R-HSA-9701529] p-Y705, p-S727 STAT3 dimer translocates to the nucleus - Homo sapiens [Pathway:R-HSA-9701898] STAT3 nuclear events downstream of ALK signaling - Homo sapiens [BlackBoxEvent:R-HSA-9725117] ALK gene expression - Homo sapiens [Reaction:R-HSA-9725332] MYC/MYCN bind the ALK gene - Homo sapiens [BlackBoxEvent:R-HSA-9725315] ALK-stimulated MYCN gene expression - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9842481] Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system [LiteratureReference:9842765] Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma [LiteratureReference:9842721] ALK Inhibitor Response in Melanomas Expressing EML4-ALK Fusions and Alternate ALK Isoforms [LiteratureReference:9842808] Translocations involving anaplastic lymphoma kinase (ALK) [LiteratureReference:9667881] The anaplastic lymphoma kinase in the pathogenesis of cancer [LiteratureReference:9699768] Role and targeting of anaplastic lymphoma kinase in cancer [LiteratureReference:9667872] Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology [LiteratureReference:9718441] The role of the ALK receptor in cancer biology [LiteratureReference:9667873] The ALK receptor in sympathetic neuron development and neuroblastoma [LiteratureReference:9724958] The Transcriptional Roles of ALK Fusion Proteins in Tumorigenesis [LiteratureReference:9842755] Assessment of the transforming potential of novel anaplastic lymphoma kinase point mutants [LiteratureReference:201494] Identification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophin [LiteratureReference:9667900] Midkine binds to anaplastic lymphoma kinase (ALK) and acts as a growth factor for different cell types [LiteratureReference:9842807] In contrast to agonist monoclonal antibodies, both C-terminal truncated form and full length form of Pleiotrophin failed to activate vertebrate ALK (anaplastic lymphoma kinase)? [LiteratureReference:9842748] Activation and inhibition of anaplastic lymphoma kinase receptor tyrosine kinase by monoclonal antibodies and absence of agonist activity of pleiotrophin [LiteratureReference:9699627] ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth [LiteratureReference:9667906] ALK receptor activation, ligands and therapeutic targeting in glioblastoma and in other cancers [LiteratureReference:9667871] The midkine family of growth factors: diverse roles in nervous system formation and maintenance [LiteratureReference:9667877] Targeting midkine and pleiotrophin signalling pathways in addiction and neurodegenerative disorders: recent progress and perspectives [LiteratureReference:9842437] Deorphanization of the human leukocyte tyrosine kinase (LTK) receptor by a signaling screen of the extracellular proteome [LiteratureReference:9842539] FAM150A and FAM150B are activating ligands for anaplastic lymphoma kinase [LiteratureReference:9842433] Augmentor ? and ? (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand-receptor interactions [LiteratureReference:9842490] Identification of a biologically active fragment of ALK and LTK-Ligand 2 (augmentor-?) [LiteratureReference:9842445] Mechanism for the activation of the anaplastic lymphoma kinase receptor [LiteratureReference:9842742] ALKALs are in vivo ligands for ALK family receptor tyrosine kinases in the neural crest and derived cells [LiteratureReference:9842419] Structural basis of cytokine-mediated activation of ALK family receptors [LiteratureReference:9842728] ALK ligand ALKAL2 potentiates MYCN-driven neuroblastoma in the absence of ALK mutation [LiteratureReference:9667892] Anaplastic lymphoma kinase: "Ligand Independent Activation" mediated by the PTN/RPTP?/? signaling pathway [LiteratureReference:9699630] Activation of anaplastic lymphoma kinase receptor tyrosine kinase induces neuronal differentiation through the mitogen-activated protein kinase pathway [LiteratureReference:201497] Role of the subcellular localization of ALK tyrosine kinase domain in neuronal differentiation of PC12 cells [LiteratureReference:9699620] ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation [LiteratureReference:9842772] Identification of ALK in Thinness [LiteratureReference:9842764] Binge-like ethanol drinking activates anaplastic lymphoma kinase signaling and increases the expression of STAT3 target genes in the mouse hippocampus and prefrontal cortex
maxDepth	3
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Signaling by ALK
orthologousEvent	[Pathway:R-DDI-201556] Signaling by ALK - Dictyostelium discoideum [Pathway:R-CEL-201556] Signaling by ALK - Caenorhabditis elegans [Pathway:R-DME-201556] Signaling by ALK - Drosophila melanogaster [Pathway:R-GGA-201556] Signaling by ALK - Gallus gallus [Pathway:R-XTR-201556] Signaling by ALK - Xenopus tropicalis [Pathway:R-DRE-201556] Signaling by ALK - Danio rerio [Pathway:R-SSC-201556] Signaling by ALK - Sus scrofa [Pathway:R-BTA-201556] Signaling by ALK - Bos taurus [Pathway:R-CFA-201556] Signaling by ALK - Canis familiaris [Pathway:R-RNO-201556] Signaling by ALK - Rattus norvegicus [Pathway:R-MMU-201556] Signaling by ALK - Mus musculus
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2021-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9729891] Inghirami, Giorgio, 2021-05-04 [InstanceEdit:9852935] Turner, Suzanne, 2023-11-08
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-201556
summation	[Summation:201558] The anaplastic lymphoma kinase (ALK) is a transmembrane rece...
updateTrackers	[UpdateTracker:9853208] Update Tracker - [Pathway:201556] Signaling by ALK - v87:[add_removeHasEvent, add_removeLiteratureReference, modifyText, updateContainedPathway, updateContainedRLE, updateIndirectRLE]

Referrals

(hasEvent)	[Pathway:R-HSA-9006934] Signaling by Receptor Tyrosine Kinases
(normalPathway)	[Pathway:R-HSA-9700206] Signaling by ALK in cancer [Pathway:R-HSA-9725370] Signaling by ALK fusions and activated point mutants [Pathway:R-HSA-9700649] Drug resistance of ALK mutants [Pathway:R-HSA-9717323] ceritinib-resistant ALK mutants [Pathway:R-HSA-9717326] crizotinib-resistant ALK mutants [Pathway:R-HSA-9717329] lorlatinib-resistant ALK mutants [Pathway:R-HSA-9717264] ASP-3026-resistant ALK mutants [Pathway:R-HSA-9717319] brigatinib-resistant ALK mutants [Pathway:R-HSA-9717301] NVP-TAE684-resistant ALK mutants [Pathway:R-HSA-9717316] alectinib-resistant ALK mutants [Pathway:R-HSA-9700645] ALK mutants bind TKIs
(updatedInstance)	[UpdateTracker:9853208] Update Tracker - [Pathway:201556] Signaling by ALK - v87:[add_removeHasEvent, add_removeLiteratureReference, modifyText, updateContainedPathway, updateContainedRLE, updateIndirectRLE]

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