Reactome | AKT translocates to the nucleus

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AKT translocates to the nucleus Show undefined attributes

authored	[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
category	transition
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:198310] 2007-07-10 08:01:55
dbId	198298
diseaseReaction	[Reaction:R-HSA-2399997] AKT1 E17K mutant translocates to the nucleus - Homo sapiens
displayName	AKT translocates to the nucleus
eventOf	[Pathway:R-HSA-1257604] PIP3 activates AKT signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-199839] AKT can phosphorylate RSK - Homo sapiens [Reaction:R-HSA-199863] AKT can phosphorylate NR4A1 (NUR77) - Homo sapiens [Reaction:R-HSA-199299] AKT phosphorylates FOXO transcription factors - Homo sapiens [Reaction:R-HSA-199298] AKT phosphorylates CREB1 - Homo sapiens [Reaction:R-HSA-8939963] Activated AKT phosphorylates RUNX2 - Homo sapiens
inferredFrom	[Reaction:R-RNO-198333] Akt translocates to the nucleus - Rattus norvegicus
input	[CandidateSet:R-HSA-202074] p-T,p-S-AKT [cytosol]
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:199341] Threonine 308 phosphorylated form of Akt translocates to the nucleus of PC12 cells under nerve growth factor stimulation and associates with the nuclear matrix protein nucleolin
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	AKT translocates to the nucleus
output	[CandidateSet:R-HSA-202072] p-T,p-S-AKT [nucleoplasm]
precedingEvent	[Reaction:R-HSA-198270] PDPK1 phosphorylates AKT at T308 - Homo sapiens
releaseDate	2008-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-198298
summation	[Summation:198332] AKT, phosphorylated at threonine (AKT1 308; AKT2 309; AKT3 3...
updateTrackers	[UpdateTracker:9788376] Update Tracker - [Reaction:198298] AKT translocates to the nucleus - v42:[modifyText] [UpdateTracker:9784298] Update Tracker - [Reaction:198298] AKT translocates to the nucleus - v54:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9788376] Update Tracker - [Reaction:198298] AKT translocates to the nucleus - v42:[modifyText] [UpdateTracker:9784298] Update Tracker - [Reaction:198298] AKT translocates to the nucleus - v54:[addLiteratureReference, modifyText]
(normalReaction)	[Reaction:R-HSA-2399997] AKT1 E17K mutant translocates to the nucleus
(precedingEvent)	[Reaction:R-HSA-8939963] Activated AKT phosphorylates RUNX2 [Reaction:R-HSA-199839] AKT can phosphorylate RSK [Reaction:R-HSA-199863] AKT can phosphorylate NR4A1 (NUR77) [Reaction:R-HSA-199299] AKT phosphorylates FOXO transcription factors [Reaction:R-HSA-199298] AKT phosphorylates CREB1
(hasEvent)	[Pathway:R-HSA-1257604] PIP3 activates AKT signaling
(inferredTo)	[Reaction:R-RNO-198333] Akt translocates to the nucleus