Reactome | MTOR signalling

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MTOR signalling Show undefined attributes

authored	[InstanceEdit:5667118] Jupe, Steve, 2015-01-23
created	[InstanceEdit:165161] de Bono, B, 2005-08-01 10:10:30
dbId	165159
displayName	MTOR signalling
doi	10.3180/R-HSA-165159.9
edited	[InstanceEdit:5667118] Jupe, Steve, 2015-01-23
eventOf	[TopLevelPathway:R-HSA-162582] Signal Transduction - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-HSA-165181] Inhibition of TSC complex formation by AKT (PKB) - Homo sapiens [Reaction:R-HSA-165195] GTP loading by Rheb - Homo sapiens [Reaction:R-HSA-5653957] Rag dimer formation - Homo sapiens [Reaction:R-HSA-5653936] Formation of Ragulator complex - Homo sapiens [Reaction:R-HSA-5653974] Ragulator binds Rag dimers - Homo sapiens [Reaction:R-HSA-8952716] SLC38A9 binds Ragulator:Rag dimers - Homo sapiens [Reaction:R-HSA-8952726] SLC38A9 transports L-Arg from lysosomal lumen to cytosol - Homo sapiens [Reaction:R-HSA-5653968] Ragulator:Rag dimers:SLC38A9 bind mTORC1 - Homo sapiens [Reaction:R-HSA-165680] Formation of active mTORC1 complex - Homo sapiens [Reaction:R-HSA-9982545] miR-142-3p RISC binds AKT1S1 mRNA - Homo sapiens [BlackBoxEvent:R-HSA-9982562] AKT1S1 mRNA translation is inhibited by miR-142-3p - Homo sapiens [BlackBoxEvent:R-HSA-9982605] miR-142-3p expression is inhibited by mTORC1 - Homo sapiens [Reaction:R-HSA-5672843] AKT1S1 (PRAS40) binds mTORC1 - Homo sapiens [Reaction:R-HSA-377186] Activated AKT phosphorylates AKT1S1 (PRAS40) - Homo sapiens [Reaction:R-HSA-5672824] Phosphorylated AKT1S1 binds YWHAB - Homo sapiens [Reaction:R-HSA-5672828] mTORC1 phosphorylates AKT1S1 - Homo sapiens [Reaction:R-HSA-9975250] PGK1 phosphorylates AKT1S1 - Homo sapiens [Pathway:R-HSA-166208] mTORC1-mediated signalling - Homo sapiens [Pathway:R-HSA-380972] Energy dependent regulation of mTOR by LKB1-AMPK - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2023-03-29
literatureReference	[LiteratureReference:5655429] mTOR: from growth signal integration to cancer, diabetes and ageing [LiteratureReference:9982836] Diverse signaling mechanisms of mTOR complexes: mTORC1 and mTORC2 in forming a formidable relationship [LiteratureReference:5655434] mTOR signaling in growth control and disease [LiteratureReference:9982840] The central moTOR of metabolism
maxDepth	3
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	MTOR signalling
orthologousEvent	[Pathway:R-GGA-165159] MTOR signalling - Gallus gallus [Pathway:R-MMU-165159] MTOR signalling - Mus musculus [Pathway:R-RNO-165159] MTOR signalling - Rattus norvegicus [Pathway:R-CFA-165159] MTOR signalling - Canis familiaris [Pathway:R-BTA-165159] MTOR signalling - Bos taurus [Pathway:R-SSC-165159] MTOR signalling - Sus scrofa [Pathway:R-DRE-165159] MTOR signalling - Danio rerio [Pathway:R-XTR-165159] MTOR signalling - Xenopus tropicalis [Pathway:R-DME-165159] MTOR signalling - Drosophila melanogaster [Pathway:R-CEL-165159] MTOR signalling - Caenorhabditis elegans [Pathway:R-SCE-165159] MTOR signalling - Saccharomyces cerevisiae [Pathway:R-SPO-165159] MTOR signalling - Schizosaccharomyces pombe [Pathway:R-DDI-165159] MTOR signalling - Dictyostelium discoideum
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2005-04-11
releaseStatus	UPDATED
reviewStatus	[ReviewStatus:9821385] four stars
reviewed	[InstanceEdit:5693188] Zwartkruis, Fried J T, 2015-05-14
revised	[InstanceEdit:5687545] Jupe, Steve, 2015-04-08
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-165159
summation	[Summation:5655425] Mammalian target of rapamycin (mTOR) is a highly conserved s...
updateTrackers	[UpdateTracker:9781655] Update Tracker - [Pathway:165159] MTOR signalling - v60:[addHasEvent, updateContainedRLE] [UpdateTracker:9786060] Update Tracker - [Pathway:165159] MTOR signalling - v50:[updateContainedRLE] [UpdateTracker:9788111] Update Tracker - [Pathway:165159] MTOR signalling - v44:[updateContainedRLE, updateIndirectRLE] [UpdateTracker:9791195] Update Tracker - [Pathway:165159] MTOR signalling - v32:[addHasEvent] [UpdateTracker:9783832] Update Tracker - [Pathway:165159] MTOR signalling - v55:[updateIndirectRLE] [UpdateTracker:9784725] Update Tracker - [Pathway:165159] MTOR signalling - v53:[addHasEvent, updateContainedPathway, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9783236] Update Tracker - [Pathway:165159] MTOR signalling - v57:[updateContainedRLE] [UpdateTracker:9782588] Update Tracker - [Pathway:165159] MTOR signalling - v59:[updateContainedRLE] [UpdateTracker:9984742] Update Tracker - [Pathway:165159] MTOR signalling - v96:[modifyText, removeHasEvent, removeLiteratureReference] [UpdateTracker:9785266] Update Tracker - [Pathway:165159] MTOR signalling - v52:[addLiteratureReference, addSummation, updateContainedPathway, updateContainedRLE] [UpdateTracker:9776669] Update Tracker - [Pathway:165159] MTOR signalling - v74:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9783674] Update Tracker - [Pathway:165159] MTOR signalling - v56:[updateIndirectRLE] [UpdateTracker:9910947] Update Tracker - [Pathway:165159] MTOR signalling - v89:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9846800] Update Tracker - [Pathway:165159] MTOR signalling - v84:[updateIndirectRLE]

Referrals

(hasEvent)	[TopLevelPathway:R-HSA-162582] Signal Transduction
(hasEncapsulatedEvent)	[Pathway:R-HSA-1257604] PIP3 activates AKT signaling [Pathway:R-HSA-380972] Energy dependent regulation of mTOR by LKB1-AMPK [Pathway:R-HSA-74752] Signaling by Insulin receptor [Pathway:R-HSA-2404192] Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
(updatedInstance)	[UpdateTracker:9781655] Update Tracker - [Pathway:165159] MTOR signalling - v60:[addHasEvent, updateContainedRLE] [UpdateTracker:9786060] Update Tracker - [Pathway:165159] MTOR signalling - v50:[updateContainedRLE] [UpdateTracker:9788111] Update Tracker - [Pathway:165159] MTOR signalling - v44:[updateContainedRLE, updateIndirectRLE] [UpdateTracker:9791195] Update Tracker - [Pathway:165159] MTOR signalling - v32:[addHasEvent] [UpdateTracker:9783832] Update Tracker - [Pathway:165159] MTOR signalling - v55:[updateIndirectRLE] [UpdateTracker:9784725] Update Tracker - [Pathway:165159] MTOR signalling - v53:[addHasEvent, updateContainedPathway, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9783236] Update Tracker - [Pathway:165159] MTOR signalling - v57:[updateContainedRLE] [UpdateTracker:9782588] Update Tracker - [Pathway:165159] MTOR signalling - v59:[updateContainedRLE] [UpdateTracker:9984742] Update Tracker - [Pathway:165159] MTOR signalling - v96:[modifyText, removeHasEvent, removeLiteratureReference] [UpdateTracker:9785266] Update Tracker - [Pathway:165159] MTOR signalling - v52:[addLiteratureReference, addSummation, updateContainedPathway, updateContainedRLE] [UpdateTracker:9776669] Update Tracker - [Pathway:165159] MTOR signalling - v74:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9783674] Update Tracker - [Pathway:165159] MTOR signalling - v56:[updateIndirectRLE] [UpdateTracker:9910947] Update Tracker - [Pathway:165159] MTOR signalling - v89:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9846800] Update Tracker - [Pathway:165159] MTOR signalling - v84:[updateIndirectRLE]

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