Reactome | PI3K/AKT Signaling in Cancer

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PI3K/AKT Signaling in Cancer Show undefined attributes

authored	[InstanceEdit:2422427] Orlic-Milacic, M, 2012-07-18
created	[InstanceEdit:2219531] Orlic-Milacic, M, 2012-05-01
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	2219528
disease	[Disease:1500689] cancer
displayName	PI3K/AKT Signaling in Cancer
doi	10.3180/REACT_147723.1
edited	[InstanceEdit:2426555] Matthews, L, 2012-08-03
eventOf	[Pathway:R-HSA-5663202] Diseases of signal transduction by growth factor receptors and second messengers - Homo sapiens
figure	[Figure:9707098] /figures/ehld/R-HSA-2219528.svg
hasDiagram	true
hasEHLD	true
hasEvent	[Pathway:R-HSA-2219530] Constitutive Signaling by Aberrant PI3K in Cancer - Homo sapiens [Pathway:R-HSA-5674400] Constitutive Signaling by AKT1 E17K in Cancer - Homo sapiens [Pathway:R-HSA-5674404] PTEN Loss of Function in Cancer - Homo sapiens
isInDisease	true
isInferred	false
lastUpdatedDate	2022-04-07
literatureReference	[LiteratureReference:1495994] AKT/PKB signaling: navigating downstream [LiteratureReference:2399870] Targeting the phosphoinositide 3-kinase pathway in cancer [LiteratureReference:2318613] PTEN loss in the continuum of common cancers, rare syndromes and mouse models [LiteratureReference:2399562] The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations [LiteratureReference:2399575] The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells [LiteratureReference:2399592] Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit [LiteratureReference:2399617] Mutations in the catalytic subunit of class IA PI3K confer leukemogenic potential to hematopoietic cells [LiteratureReference:2399685] Cancer-derived mutations in the regulatory subunit p85alpha of phosphoinositide 3-kinase function through the catalytic subunit p110alpha [LiteratureReference:2399688] Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation [LiteratureReference:2399690] PIK3R1 (p85?) is somatically mutated at high frequency in primary endometrial cancer [LiteratureReference:2317361] PTEN1 is frequently mutated in primary endometrial carcinomas [LiteratureReference:2317505] Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association [LiteratureReference:1889775] Functional evaluation of PTEN missense mutations using in vitro phosphoinositide phosphatase assay [LiteratureReference:2318432] Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation [LiteratureReference:2219532] Molecular mechanism of an oncogenic mutation that alters membrane targeting: Glu17Lys modifies the PIP lipid specificity of the AKT1 PH domain [LiteratureReference:1500571] A transforming mutation in the pleckstrin homology domain of AKT1 in cancer [LiteratureReference:2318761] The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo [LiteratureReference:2458350] Hot-spot mutations in p110alpha of phosphatidylinositol 3-kinase (pI3K): differential interactions with the regulatory subunit p85 and with RAS
maxDepth	3
modified	[InstanceEdit:9847082] Weiser, Joel, 2023-10-12
name	PI3K/AKT Signaling in Cancer
normalPathway	[Pathway:R-HSA-1257604] PIP3 activates AKT signaling
releaseDate	2012-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2463860] Thorpe, Lauren, 2012-08-13 [InstanceEdit:2463859] Yuzugullu, Haluk, 2012-08-13 [InstanceEdit:2463854] Zhao, Jean J, 2012-08-13
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-2219528
summation	[Summation:2219521] Class IA PI3K is a heterodimer of a p85 regulatory subunit (...
updateTrackers	[UpdateTracker:9782745] Update Tracker - [Pathway:2219528] PI3K/AKT Signaling in Cancer - v58:[updateIndirectRLE] [UpdateTracker:9777444] Update Tracker - [Pathway:2219528] PI3K/AKT Signaling in Cancer - v71:[updateIndirectRLE] [UpdateTracker:9788029] Update Tracker - [Pathway:2219528] PI3K/AKT Signaling in Cancer - v44:[updateIndirectRLE] [UpdateTracker:9785430] Update Tracker - [Pathway:2219528] PI3K/AKT Signaling in Cancer - v52:[addLiteratureReference, add_removeHasEvent, add_removeSummation, updateContainedPathway] [UpdateTracker:9784469] Update Tracker - [Pathway:2219528] PI3K/AKT Signaling in Cancer - v54:[updateIndirectRLE] [UpdateTracker:9779169] Update Tracker - [Pathway:2219528] PI3K/AKT Signaling in Cancer - v66:[updateIndirectRLE] [UpdateTracker:9777850] Update Tracker - [Pathway:2219528] PI3K/AKT Signaling in Cancer - v68:[updateIndirectRLE] [UpdateTracker:9774967] Update Tracker - [Pathway:2219528] PI3K/AKT Signaling in Cancer - v80:[updateIndirectRLE]

Referrals

(updatedInstance)

[UpdateTracker:9782745] Update Tracker - [Pathway:2219528] PI3K/AKT Signaling in Cancer - v58:[updateIndirectRLE]
[UpdateTracker:9777444] Update Tracker - [Pathway:2219528] PI3K/AKT Signaling in Cancer - v71:[updateIndirectRLE]
[UpdateTracker:9788029] Update Tracker - [Pathway:2219528] PI3K/AKT Signaling in Cancer - v44:[updateIndirectRLE]
[UpdateTracker:9785430] Update Tracker - [Pathway:2219528] PI3K/AKT Signaling in Cancer - v52:[addLiteratureReference, add_removeHasEvent, add_removeSummation, updateContainedPathway]
[UpdateTracker:9784469] Update Tracker - [Pathway:2219528] PI3K/AKT Signaling in Cancer - v54:[updateIndirectRLE]
[UpdateTracker:9779169] Update Tracker - [Pathway:2219528] PI3K/AKT Signaling in Cancer - v66:[updateIndirectRLE]
[UpdateTracker:9777850] Update Tracker - [Pathway:2219528] PI3K/AKT Signaling in Cancer - v68:[updateIndirectRLE]
[UpdateTracker:9774967] Update Tracker - [Pathway:2219528] PI3K/AKT Signaling in Cancer - v80:[updateIndirectRLE]

(hasEvent)

[Pathway:R-HSA-5663202] Diseases of signal transduction by growth factor receptors and second messengers

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