Reactome | Co-stimulation by CD28

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Co-stimulation by CD28 Show undefined attributes

authored	[InstanceEdit:388810] Garapati, P V, 2008-12-16 11:12:19 [InstanceEdit:9927528] Garapati, Phani Vijay, 2024-11-07
created	[InstanceEdit:389358] Garapati, P V, 2009-01-06 13:43:48
crossReference	[DatabaseIdentifier:12819465] BioModels Database:BIOMD0000000255 [DatabaseIdentifier:12819471] BioModels Database:BIOMD0000000175 [DatabaseIdentifier:12819431] BioModels Database:BIOMD0000000883 [DatabaseIdentifier:12819511] BioModels Database:BIOMD0000000468
dbId	389356
displayName	Co-stimulation by CD28
edited	[InstanceEdit:388810] Garapati, P V, 2008-12-16 11:12:19 [InstanceEdit:9927533] Tiwari, Krishna, 2024-11-07
eventOf	[Pathway:R-HSA-388841] Regulation of T cell activation by CD28 family - Homo sapiens
figure	[Figure:9689482] /figures/static/R-HSA-389356.svg
goBiologicalProcess	[GO_BiologicalProcess:173020] T cell costimulation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-388811] CD28 homodimer binds B7-1 homodimer - Homo sapiens [Reaction:R-HSA-388808] CD28 homodimer binds B7-2 monomer - Homo sapiens [Reaction:R-HSA-388831] Phosphorylation of CD28 - Homo sapiens [Reaction:R-HSA-389381] Gads binds CD28 - Homo sapiens [Pathway:R-HSA-389357] CD28 dependent PI3K/Akt signaling - Homo sapiens [Pathway:R-HSA-389359] CD28 dependent Vav1 pathway - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2022-04-07
literatureReference	[LiteratureReference:389265] CD28 costimulation: a source of Vav-1 for TCR signaling with the help of SLP-76? [LiteratureReference:388687] Differential recognition by CD28 of its cognate counter receptors CD80 (B7.1) and B70 (B7.2): analysis by site directed mutagenesis [LiteratureReference:388646] Interactions of CD80 and CD86 with CD28 and CTLA4
maxDepth	3
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Co-stimulation by CD28 CD28 co-stimulation
orthologousEvent	[Pathway:R-MMU-389356] Co-stimulation by CD28 - Mus musculus [Pathway:R-RNO-389356] Co-stimulation by CD28 - Rattus norvegicus [Pathway:R-CFA-389356] Co-stimulation by CD28 - Canis familiaris [Pathway:R-BTA-389356] Co-stimulation by CD28 - Bos taurus [Pathway:R-SSC-389356] Co-stimulation by CD28 - Sus scrofa [Pathway:R-DRE-389356] Co-stimulation by CD28 - Danio rerio [Pathway:R-XTR-389356] Co-stimulation by CD28 - Xenopus tropicalis [Pathway:R-GGA-389356] Co-stimulation by CD28 - Gallus gallus [Pathway:R-PFA-389356] Co-stimulation by CD28 - Plasmodium falciparum [Pathway:R-DDI-389356] Co-stimulation by CD28 - Dictyostelium discoideum [Pathway:R-SPO-389356] Co-stimulation by CD28 - Schizosaccharomyces pombe [Pathway:R-SCE-389356] Co-stimulation by CD28 - Saccharomyces cerevisiae [Pathway:R-CEL-389356] Co-stimulation by CD28 - Caenorhabditis elegans [Pathway:R-DME-389356] Co-stimulation by CD28 - Drosophila melanogaster
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:422514] Bluestone, JA, Esensten, J, 2009-06-01 18:47:33 [InstanceEdit:9927529] D'Eustachio, Peter, 2024-11-07
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-389356
summation	[Summation:389264] CD28 signaling plays a critical role in shaping immune respo...
updateTrackers	[UpdateTracker:9790226] Update Tracker - [Pathway:389356] CD28 co-stimulation - v34:[updateContainedRLE] [UpdateTracker:9785385] Update Tracker - [Pathway:389356] CD28 co-stimulation - v52:[updateIndirectRLE] [UpdateTracker:9782509] Update Tracker - [Pathway:389356] CD28 co-stimulation - v59:[updateIndirectRLE] [UpdateTracker:9789222] Update Tracker - [Pathway:389356] CD28 co-stimulation - v38:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9775141] Update Tracker - [Pathway:389356] CD28 co-stimulation - v80:[updateIndirectRLE] [UpdateTracker:9780089] Update Tracker - [Pathway:389356] CD28 co-stimulation - v64:[updateIndirectRLE] [UpdateTracker:9928441] Update Tracker - [Pathway:389356] Co-stimulation by CD28 - v91:[modifyText] [UpdateTracker:9788342] Update Tracker - [Pathway:389356] CD28 co-stimulation - v42:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9789864] Update Tracker - [Pathway:389356] CD28 co-stimulation - v37:[updateIndirectRLE] [UpdateTracker:9791341] Update Tracker - [Pathway:389356] CD28 co-stimulation - v31:[updateIndirectRLE] [UpdateTracker:9791224] Update Tracker - [Pathway:389356] CD28 co-stimulation - v32:[updateIndirectRLE] [UpdateTracker:9785712] Update Tracker - [Pathway:389356] CD28 co-stimulation - v51:[updateIndirectRLE] [UpdateTracker:9777254] Update Tracker - [Pathway:389356] CD28 co-stimulation - v72:[updateContainedRLE]

Referrals

(hasEvent)	[Pathway:R-HSA-388841] Regulation of T cell activation by CD28 family
(hasEncapsulatedEvent)	[Pathway:R-HSA-389513] Co-inhibition by CTLA4
(updatedInstance)	[UpdateTracker:9790226] Update Tracker - [Pathway:389356] CD28 co-stimulation - v34:[updateContainedRLE] [UpdateTracker:9785385] Update Tracker - [Pathway:389356] CD28 co-stimulation - v52:[updateIndirectRLE] [UpdateTracker:9782509] Update Tracker - [Pathway:389356] CD28 co-stimulation - v59:[updateIndirectRLE] [UpdateTracker:9789222] Update Tracker - [Pathway:389356] CD28 co-stimulation - v38:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9775141] Update Tracker - [Pathway:389356] CD28 co-stimulation - v80:[updateIndirectRLE] [UpdateTracker:9780089] Update Tracker - [Pathway:389356] CD28 co-stimulation - v64:[updateIndirectRLE] [UpdateTracker:9928441] Update Tracker - [Pathway:389356] Co-stimulation by CD28 - v91:[modifyText] [UpdateTracker:9788342] Update Tracker - [Pathway:389356] CD28 co-stimulation - v42:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9789864] Update Tracker - [Pathway:389356] CD28 co-stimulation - v37:[updateIndirectRLE] [UpdateTracker:9791341] Update Tracker - [Pathway:389356] CD28 co-stimulation - v31:[updateIndirectRLE] [UpdateTracker:9791224] Update Tracker - [Pathway:389356] CD28 co-stimulation - v32:[updateIndirectRLE] [UpdateTracker:9785712] Update Tracker - [Pathway:389356] CD28 co-stimulation - v51:[updateIndirectRLE] [UpdateTracker:9777254] Update Tracker - [Pathway:389356] CD28 co-stimulation - v72:[updateContainedRLE]

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