Reactome | Signaling by PDGF

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Signaling by PDGF Show undefined attributes

authored	[InstanceEdit:382627] Garapati, P V, Jassal, B, 2008-11-24 10:14:27
created	[InstanceEdit:186802] Jassal, B, 2006-08-15 13:51:10
crossReference	[DatabaseIdentifier:12325440] BioModels Database:BIOMD0000000288
dbId	186797
displayName	Signaling by PDGF
doi	10.3180/REACT_16888.1
edited	[InstanceEdit:382627] Garapati, P V, Jassal, B, 2008-11-24 10:14:27
eventOf	[Pathway:R-HSA-9006934] Signaling by Receptor Tyrosine Kinases - Homo sapiens
figure	[Figure:2291917] /figures/Pathway_Illustrations/PDGF_72_oicr.png
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-382053] Translocation of PDGF from ER to Golgi - Homo sapiens [Reaction:R-HSA-186785] PDGF-AA clevage by Furin - Homo sapiens [Reaction:R-HSA-8865275] PDGF-BB clevage by Furin - Homo sapiens [Reaction:R-HSA-8865276] PDGF-AB clevage by Furin - Homo sapiens [BlackBoxEvent:R-HSA-382057] Release of novel PDGFs as latent factors - Homo sapiens [Reaction:R-HSA-382061] Extracellular processing of novel PDGFs - Homo sapiens [Reaction:R-HSA-382054] PDGF binds to extracellular matrix proteins - Homo sapiens [BlackBoxEvent:R-HSA-186773] PDGF dimer binds two receptors simultaneously - Homo sapiens [Reaction:R-HSA-186786] Autophosphorylation of PDGF beta receptors - Homo sapiens [Reaction:R-HSA-389083] Autophosphorylation of PDGF alpha receptors - Homo sapiens [Reaction:R-HSA-389086] Autophosphorylation of PDGF alpha/beta receptors - Homo sapiens [Pathway:R-HSA-186763] Downstream signal transduction - Homo sapiens [Reaction:R-HSA-8864036] PTPN12 dephosphorylates PDGFRB at Y1021 - Homo sapiens [Reaction:R-HSA-9674015] Olaratumab binds PDGFRA - Homo sapiens [Reaction:R-HSA-9674093] PDGFRs bind type I TKI - Homo sapiens [Reaction:R-HSA-9674095] PDGFRs bind type II TKI - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:380730] Mechanism of action and in vivo role of platelet-derived growth factor [LiteratureReference:380735] Signal transduction via platelet-derived growth factor receptors [LiteratureReference:380726] The PDGF family: four gene products form five dimeric isoforms
modified	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name	Signaling by PDGF
orthologousEvent	[Pathway:R-MMU-186797] Signaling by PDGF - Mus musculus [Pathway:R-RNO-186797] Signaling by PDGF - Rattus norvegicus [Pathway:R-CFA-186797] Signaling by PDGF - Canis familiaris [Pathway:R-BTA-186797] Signaling by PDGF - Bos taurus [Pathway:R-SSC-186797] Signaling by PDGF - Sus scrofa [Pathway:R-DRE-186797] Signaling by PDGF - Danio rerio [Pathway:R-XTR-186797] Signaling by PDGF - Xenopus tropicalis [Pathway:R-GGA-186797] Signaling by PDGF - Gallus gallus [Pathway:R-DME-186797] Signaling by PDGF - Drosophila melanogaster [Pathway:R-CEL-186797] Signaling by PDGF - Caenorhabditis elegans
releaseDate	2009-04-01
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:382617] Heldin, CH, 2008-11-23 19:29:34
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-186797
summation	[Summation:186835] Platelet-derived Growth Factor (PDGF) is a potent stimulator...

Referrals

(hasEvent)	[Pathway:R-HSA-9006934] Signaling by Receptor Tyrosine Kinases
(hasEncapsulatedEvent)	[Pathway:R-HSA-5673001] RAF/MAP kinase cascade [Pathway:R-HSA-1257604] PIP3 activates AKT signaling
(normalPathway)	[Pathway:R-HSA-9671555] Signaling by PDGFR in disease [Pathway:R-HSA-9674428] PDGFR mutants bind TKIs [Pathway:R-HSA-9674415] Drug resistance of PDGFR mutants [Pathway:R-HSA-9674396] Imatinib-resistant PDGFR mutants [Pathway:R-HSA-9673767] Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants [Pathway:R-HSA-9673766] Signaling by cytosolic PDGFRA and PDGFRB fusion proteins [Pathway:R-HSA-9673770] Signaling by PDGFRA extracellular domain mutants [Pathway:R-HSA-9673768] Signaling by membrane-tethered fusions of PDGFRA or PDGFRB [Pathway:R-HSA-9674403] Regorafenib-resistant PDGFR mutants [Pathway:R-HSA-9674401] Sunitinib-resistant PDGFR mutants [Pathway:R-HSA-9674404] Sorafenib-resistant PDGFR mutants

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