Reactome | mTORC2 phosphorylates AKT at S473

Schema > Reaction > Entries

mTORC2 phosphorylates AKT at S473 Show undefined attributes

authored	[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
catalystActivity	[CatalystActivity:198624] protein serine/threonine kinase activity of mTORC2:PIP3 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:198616] Jassal, B, 2007-06-29 07:57:48
dbId	198640
displayName	mTORC2 phosphorylates AKT at S473
edited	[InstanceEdit:2426555] Matthews, L, 2012-08-03
eventOf	[Pathway:R-HSA-389357] CD28 dependent PI3K/Akt signaling - Homo sapiens [Pathway:R-HSA-5218920] VEGFR2 mediated vascular permeability - Homo sapiens
followingEvent	[Reaction:R-HSA-2317314] AKT binds PDPK1 - Homo sapiens
input	[Complex:R-HSA-2317329] AKT:PIP3 [plasma membrane] [SimpleEntity:R-ALL-113592] ATP [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:199373] Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex [LiteratureReference:199317] Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	mTORC2 phosphorylates AKT at S473
orthologousEvent	[Reaction:R-SCE-198640] mTORC2 phosphorylates AKT at S473 - Saccharomyces cerevisiae [Reaction:R-SPO-198640] mTORC2 phosphorylates AKT at S473 - Schizosaccharomyces pombe [Reaction:R-DDI-198640] mTORC2 phosphorylates AKT at S473 - Dictyostelium discoideum [Reaction:R-CEL-198640] mTORC2 phosphorylates AKT at S473 - Caenorhabditis elegans [Reaction:R-DME-198640] mTORC2 phosphorylates AKT at S473 - Drosophila melanogaster [Reaction:R-GGA-198640] mTORC2 phosphorylates AKT at S473 - Gallus gallus [Reaction:R-DRE-198640] mTORC2 phosphorylates AKT at S473 - Danio rerio [Reaction:R-RNO-198640] mTORC2 phosphorylates AKT at S473 - Rattus norvegicus [Reaction:R-MMU-198640] mTORC2 phosphorylates AKT at S473 - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-2317310] p-S-AKT:PIP3 [plasma membrane]
precedingEvent	[Reaction:R-HSA-2317332] PIP3 recruits AKT to the membrane - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-199457] Negative regulation by 'AKT:PIP3:THEM4/TRIB3 [plasma membrane]'
releaseDate	2008-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37 [InstanceEdit:2463860] Thorpe, Lauren, 2012-08-13 [InstanceEdit:2463859] Yuzugullu, Haluk, 2012-08-13 [InstanceEdit:2463854] Zhao, Jean J, 2012-08-13
revised	[InstanceEdit:2422427] Orlic-Milacic, M, 2012-07-18
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-198640
summation	[Summation:202051] Under conditions of growth and mitogen stimulation S473 phos...
updateTrackers	[UpdateTracker:9789479] Update Tracker - [Reaction:198640] TORC2 (mTOR) phosphorylates AKT at S473 - v38:[modifyText] [UpdateTracker:9788384] Update Tracker - [Reaction:198640] TORC2 (mTOR) phosphorylates AKT at S473 - v42:[addLiteratureReference, add_removeInput, add_removeOutput, add_removeRegulator, modifyText] [UpdateTracker:9791333] Update Tracker - [Reaction:198640] TORC2 (mTOR) phosphorylates AKT at S473 - v31:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9789479] Update Tracker - [Reaction:198640] TORC2 (mTOR) phosphorylates AKT at S473 - v38:[modifyText] [UpdateTracker:9788384] Update Tracker - [Reaction:198640] TORC2 (mTOR) phosphorylates AKT at S473 - v42:[addLiteratureReference, add_removeInput, add_removeOutput, add_removeRegulator, modifyText] [UpdateTracker:9791333] Update Tracker - [Reaction:198640] TORC2 (mTOR) phosphorylates AKT at S473 - v31:[modifyText]
(hasEvent)	[Pathway:R-HSA-5218920] VEGFR2 mediated vascular permeability [Pathway:R-HSA-389357] CD28 dependent PI3K/Akt signaling [Pathway:R-HSA-1257604] PIP3 activates AKT signaling
(precedingEvent)	[Reaction:R-HSA-2317314] AKT binds PDPK1

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