Reactome | TP53 Regulates Metabolic Genes

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TP53 Regulates Metabolic Genes Show undefined attributes

authored	[InstanceEdit:5659776] Orlic-Milacic, Marija, 2014-12-23
created	[InstanceEdit:5628895] Orlic-Milacic, Marija, 2014-10-24
dbId	5628897
displayName	TP53 Regulates Metabolic Genes
doi	10.3180/react_355328.1
edited	[InstanceEdit:5659776] Orlic-Milacic, Marija, 2014-12-23
eventOf	[Pathway:R-HSA-3700989] Transcriptional Regulation by TP53 - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-5628899] TP53 binds the TIGAR gene - Homo sapiens [BlackBoxEvent:R-HSA-5628901] TP53 stimulates TIGAR expression - Homo sapiens [Reaction:R-HSA-5628905] TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate - Homo sapiens [Reaction:R-HSA-70475] GPI dimer isomerizes Fru(6)P to G6P - Homo sapiens [Reaction:R-HSA-70377] G6PD multimers dehydrogenate G6P - Homo sapiens [Reaction:R-HSA-71682] glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ - Homo sapiens [Reaction:R-HSA-3341277] GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O - Homo sapiens [Reaction:R-HSA-5632939] TP53 binds the PTEN promoter - Homo sapiens [BlackBoxEvent:R-HSA-5632993] PTEN gene transcription is stimulated by TP53 - Homo sapiens [Reaction:R-HSA-2318752] miR-26A microRNAs bind PTEN mRNA - Homo sapiens [BlackBoxEvent:R-HSA-2321904] PTEN mRNA translation negatively regulated by microRNAs - Homo sapiens [Reaction:R-HSA-5629187] TP53 binds regulatory elements of SESN1,2,3 genes - Homo sapiens [BlackBoxEvent:R-HSA-5629189] TP53 stimulates expression of SESN1,2,3 genes - Homo sapiens [Reaction:R-HSA-3341343] PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O - Homo sapiens [Reaction:R-HSA-73646] Regeneration of active (reduced) Thioredoxin - Homo sapiens [Reaction:R-HSA-5631885] PRDX1 overoxidizes - Homo sapiens [Reaction:R-HSA-5631903] SESN1,2,3 bind overoxidized PRDX1 - Homo sapiens [Reaction:R-HSA-380927] p-AMPK phosphorylates TSC1:TSC2 - Homo sapiens [Reaction:R-HSA-380979] RHEB in mTORC1:RHEB:GTP hydrolyses GTP - Homo sapiens [Reaction:R-HSA-5631941] SESN1,2,3 bind AMPK - Homo sapiens [Reaction:R-HSA-5632393] TP63/TP53 bind the DDIT4 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-5632386] TP63/TP53 stimulates transcription of DDIT4 gene - Homo sapiens [Reaction:R-HSA-165179] Formation of TSC1:TSC2 complex - Homo sapiens [Reaction:R-HSA-198609] AKT phosphorylates TSC2, inhibiting it - Homo sapiens [Reaction:R-HSA-5632732] p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 - Homo sapiens [Reaction:R-HSA-5632738] DDIT4 binds 14-3-3 dimer - Homo sapiens [Reaction:R-HSA-5632759] TP53 binds the SCO2 gene - Homo sapiens [BlackBoxEvent:R-HSA-5632766] TP53 stimulates SCO2 gene transcription - Homo sapiens [Reaction:R-HSA-163214] Electron transfer from reduced cytochrome c to molecular oxygen - Homo sapiens [Reaction:R-HSA-5632887] TP53 binds the RRM2B gene - Homo sapiens [BlackBoxEvent:R-HSA-5632892] TP53 stimulates transcription of RRM2B gene - Homo sapiens [Reaction:R-HSA-5632914] TP53 binds the GLS2 promoter - Homo sapiens [BlackBoxEvent:R-HSA-5632924] TP53 stimulates GLS2 transcription - Homo sapiens [Reaction:R-HSA-70609] glutamine + H2O => glutamate + NH4+ (GLS) - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2022-12-07
literatureReference	[LiteratureReference:5633108] The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein [LiteratureReference:5632765] On the origin of cancer cells [LiteratureReference:5628862] TIGAR, a p53-inducible regulator of glycolysis and apoptosis [LiteratureReference:5633096] Glycolytic enzymes can modulate cellular life span [LiteratureReference:5633107] The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression [LiteratureReference:5633093] p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation [LiteratureReference:5632944] Regulation of PTEN transcription by p53 [LiteratureReference:5629163] PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes [LiteratureReference:5629169] Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability [LiteratureReference:5629185] NGF-mediated transcriptional targets of p53 in PC12 neuronal differentiation [LiteratureReference:5631890] Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD [LiteratureReference:5631926] Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses [LiteratureReference:5631909] Role of sestrin2 in peroxide signaling in macrophages [LiteratureReference:5631940] p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling [LiteratureReference:5632356] p53/TAp63 and AKT regulate mammalian target of rapamycin complex 1 (mTORC1) signaling through two independent parallel pathways in the presence of DNA damage [LiteratureReference:5632390] REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species [LiteratureReference:5632740] Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling [LiteratureReference:5632991] p53 regulates cell survival by inhibiting PIK3CA in squamous cell carcinomas [LiteratureReference:3222257] PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53 [LiteratureReference:5633106] The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways [LiteratureReference:5632749] p53 regulates mitochondrial respiration [LiteratureReference:111775] A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage [LiteratureReference:5632908] Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion [LiteratureReference:5632896] p53 regulates mtDNA copy number and mitocheckpoint pathway [LiteratureReference:5632922] Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function [LiteratureReference:5662732] Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence [LiteratureReference:5662727] p53 improves aerobic exercise capacity and augments skeletal muscle mitochondrial DNA content [LiteratureReference:5662729] Increased oxidative metabolism in the Li-Fraumeni syndrome
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	TP53 Regulates Metabolic Genes
orthologousEvent	[Pathway:R-DRE-5628897] TP53 Regulates Metabolic Genes - Danio rerio [Pathway:R-DDI-5628897] TP53 Regulates Metabolic Genes - Dictyostelium discoideum [Pathway:R-DME-5628897] TP53 Regulates Metabolic Genes - Drosophila melanogaster [Pathway:R-CEL-5628897] TP53 Regulates Metabolic Genes - Caenorhabditis elegans [Pathway:R-GGA-5628897] TP53 Regulates Metabolic Genes - Gallus gallus [Pathway:R-SSC-5628897] TP53 Regulates Metabolic Genes - Sus scrofa [Pathway:R-BTA-5628897] TP53 Regulates Metabolic Genes - Bos taurus [Pathway:R-MMU-5628897] TP53 Regulates Metabolic Genes - Mus musculus [Pathway:R-RNO-5628897] TP53 Regulates Metabolic Genes - Rattus norvegicus [Pathway:R-CFA-5628897] TP53 Regulates Metabolic Genes - Canis familiaris [Pathway:R-XTR-5628897] TP53 Regulates Metabolic Genes - Xenopus tropicalis [Pathway:R-SPO-5628897] TP53 Regulates Metabolic Genes - Schizosaccharomyces pombe [Pathway:R-SCE-5628897] TP53 Regulates Metabolic Genes - Saccharomyces cerevisiae [Pathway:R-PFA-5628897] TP53 Regulates Metabolic Genes - Plasmodium falciparum
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5662800] Hwang, Paul M, 2014-12-30 [InstanceEdit:5662803] Kang, Ju-Gyeong, 2014-12-30 [InstanceEdit:5662801] Wang, Ping-yuan, 2014-12-30 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04 [InstanceEdit:8855677] Zaccara, Sara, 2016-02-04
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5628897
summation	[Summation:5633091] While the p53 tumor suppressor protein (TP53) is known to in...
updateTrackers	[UpdateTracker:9863981] Update Tracker - [Pathway:5628897] TP53 Regulates Metabolic Genes - v88:[updateContainedRLE] [UpdateTracker:9776832] Update Tracker - [Pathway:5628897] TP53 Regulates Metabolic Genes - v74:[updateContainedRLE] [UpdateTracker:9784718] Update Tracker - [Pathway:5628897] TP53 Regulates Metabolic Genes - v53:[updateContainedRLE] [UpdateTracker:9782692] Update Tracker - [Pathway:5628897] TP53 Regulates Metabolic Genes - v59:[updateContainedRLE] [UpdateTracker:9783792] Update Tracker - [Pathway:5628897] TP53 Regulates Metabolic Genes - v55:[updateContainedRLE] [UpdateTracker:9910980] Update Tracker - [Pathway:5628897] TP53 Regulates Metabolic Genes - v89:[updateContainedRLE] [UpdateTracker:9776466] Update Tracker - [Pathway:5628897] TP53 Regulates Metabolic Genes - v76:[updateContainedRLE] [UpdateTracker:9846932] Update Tracker - [Pathway:5628897] TP53 Regulates Metabolic Genes - v83:[updateContainedRLE] [UpdateTracker:9784397] Update Tracker - [Pathway:5628897] TP53 Regulates Metabolic Genes - v54:[updateContainedRLE] [UpdateTracker:9783423] Update Tracker - [Pathway:5628897] TP53 Regulates Metabolic Genes - v56:[addHasEvent, modifyText, updateContainedRLE]

Referrals

(hasEvent)	[Pathway:R-HSA-3700989] Transcriptional Regulation by TP53
(hasEncapsulatedEvent)	[Pathway:R-HSA-9864848] Complex IV assembly
(updatedInstance)	[UpdateTracker:9863981] Update Tracker - [Pathway:5628897] TP53 Regulates Metabolic Genes - v88:[updateContainedRLE] [UpdateTracker:9776832] Update Tracker - [Pathway:5628897] TP53 Regulates Metabolic Genes - v74:[updateContainedRLE] [UpdateTracker:9784718] Update Tracker - [Pathway:5628897] TP53 Regulates Metabolic Genes - v53:[updateContainedRLE] [UpdateTracker:9782692] Update Tracker - [Pathway:5628897] TP53 Regulates Metabolic Genes - v59:[updateContainedRLE] [UpdateTracker:9783792] Update Tracker - [Pathway:5628897] TP53 Regulates Metabolic Genes - v55:[updateContainedRLE] [UpdateTracker:9910980] Update Tracker - [Pathway:5628897] TP53 Regulates Metabolic Genes - v89:[updateContainedRLE] [UpdateTracker:9776466] Update Tracker - [Pathway:5628897] TP53 Regulates Metabolic Genes - v76:[updateContainedRLE] [UpdateTracker:9846932] Update Tracker - [Pathway:5628897] TP53 Regulates Metabolic Genes - v83:[updateContainedRLE] [UpdateTracker:9784397] Update Tracker - [Pathway:5628897] TP53 Regulates Metabolic Genes - v54:[updateContainedRLE] [UpdateTracker:9783423] Update Tracker - [Pathway:5628897] TP53 Regulates Metabolic Genes - v56:[addHasEvent, modifyText, updateContainedRLE]

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